DIABETES (also see Women’s Health)

Primary Source of Funding: Parke-Davis Pharmaceuticals
Total Project Period: August 1999 – December 2002
Division of Research Principal Investigator: Joe V. Selby, MD, MPH
Description: This retrospective cohort study of diabetic patients will estimate the incidence of hospitalization for acute hepatic injury by type of diabetes treatment, with particular attention paid to newer agents such as the thiazolidinediones.

Source of Funding: National Institute of Diabetes and Digestive and Kidney Diseases
Total Project Period: September 2000 – August 2001
Division of Research Principal Investigator: Assiamira Ferrara, MD, PhD
Description: This study will provide important knowledge about the risk of severe perinatal complications associated with degrees of maternal hyperglycemia below the current glucose cut-points for gestational diabetes.

Division of Research Principal Investigator: Joe V. Selby, MD, MPH
Primary Source of Funding: American Diabetes Association B July 2000 – June 2003
Description: This study uses the Kaiser Permanente Diabetes Registry to explore clinical outcomes following negative retinal screening examinations and exams showing only minimal retinopathy, with the goal of identifying optimal screening intervals following these examinations.

Primary Source of Funding: National Heart, Lung, and Blood Institute
Total Project Period: September 1991 - August 2001
Division of Research Principal Investigator: Joe V. Selby, MD, MPH
Description: This is a multisided, cross-sectional, epidemiologic study of insulin resistance, hyperinsulinemia, and hyperglycemia and their associations with atherosclerotic disease and other cardiovascular disease risk factors. The Division of Research’s grant calls for examination of 400 individuals, age 40 to 69 years, beginning in October 1992.

Medication Use and Glucose Control Among Type 2 Diabetics
Division of Research Principal Investigator: Assiamara Ferrara, MD, PhD
Primary Source of Funding: SmithKline Beecham
Total Project Period: January 1998 – December 2003
Description: This study seeks to determine the extent and nature of polypharmacy among Type 2 diabetics; to list drug interactions that should be monitored; and to study whether glycemic control varies by medication use.

Primary Source of Funding: Centers for Disease Control and Prevention
Total Project Period: September 1999 – September 2003
Division of Research Principal Investigator: Assiamira Ferrara, MD, PhD
Description: The purpose of this study is to estimate and describe the prevalence of pre-existing diabetes and gestational diabetes in pregnancies between 1992 and 1999 among women who were members of the Kaiser Permanente Medical Care Program of Northern California.

Primary Source of Funding: Pfizer Incorporated
Total Project Period: January 2001 – December 2003
Division of Research Principal Investigator: Andrew Karter, PhD
Description: The primary aim of this epidemiologic study is to evaluate the proportion of patients with Type 2 diabetes who are switched to new diabetes therapies that reach and maintain glycemic control targets (<7% HbA1c).

Primary Source of Funding: Pfizer Incorporated
Total Project Period: January 2001 – December 2003
Division of Research Principal Investigator: Andrew Karter, PhD
Description: To study observationally how glycemic control in diabetic patients varies by treatment regimen, and how glycemic control changes over time.

Primary Source of Funding: Centers for Disease Control and Prevention
Total Project Period: September 1999 – March 2003
Division of Research Principal Investigator: Assiamira Ferrara, MD, PhD
Description: The purpose of this study is to develop case definition(s) for diagnosis and classification of Types 1 and 2 diabetes in youths that are suitable for surveillance and/or clinical purposes and to describe the quality of care received by youths with Type 2 diabetes. This study will be conducted among children and adolescents with diabetes who were aged 10 to 19 and who were members of the Kaiser Permanente Medical Care Program of Northern California between 1992 and 1999.