Fat Redistribution and Metabolic Change in HIV Infection (FRAM)
Primary Source of Funding: Northern California Institute for Research Education
TotalProject Period: October 1999 – August 2001
Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Description: This cross-sectional study will examine the prevalence of “peripheral lipodystrophy” syndrome in HIV infected patients, including fat redistribution, insulin resistance, and preatherogenic hyperlipidemia.
HIV-1 Antiretroviral Treatment: Cost-Effectiveness of Triple Combination Therapy Vs Dual Therapy under a Markov Model
Primary Source of Funding: Pharmacia
Total Project Period: February 1999 – June 2001
Division of Research Principal Investigator: Gerald N. DeLorenze, PhD
Description: This study will test a Markov chain model of the cost-benefit and quality of life adjusted cost-benefit of triple combination therapy relative to dual combination therapy.
HIV-1 Virologic Response and Survival Patterns Associated With Highly Active Antiretroviral Therapy (HAART)
Primary Source of Funding: University-wide AIDS Research
Total Project Period: July 1999 – June 2001
Division of Research Principal Investigator: Gerald N. DeLorenze, PhD
Description: The purpose of this study is three-fold: 1) to estimate rates of maximum virologic response and virologic treatment failure in HIV patients under HAART; 2) to determine the distribution of time to AIDS diagnosis and the time to death after initiation of HAART; 3) to measure health care usage trends both pre- and post- HAART.
Renal Insufficiency Among HIV-1 Patients in a Large Health Maintenance Organization
Primary Source of Funding: Gilead Sciences
Total Project Period: May 1999 – December 2001
Division of Research Principal Investigator: Gerald N. DeLorenze, PhD
Description: This study will determine the incidence of renal insufficiency among Northern California KPMCP HIV-1 patients following the introduction of highly active antiretroviral therapy (HAART).
Prevalence of Diabetes Mellitus in the HIV-Infected Kaiser Permanente, Northern California, Patient Population
Division of Research Principal Investigator: Gerald DeLorenze, PhD
Primary Source of Funding: Kaiser Foundation Research Institute
Total Project Period: January 1, 2002 – December 31, 2003
Description: This study will investigate the prevalence and incidence of diabetes mellitus among the HIV-seropositive members of the Kaiser Permanente, Northern California, Health Plan (KPNC) and compare these estimates to the general KPNC patient population through standardized morbidity ratios.
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