Restless Legs Syndrome (RLS)

Restless legs syndrome (RLS) is a condition that produces an intense, often irresistible urge to move the legs because of unpleasant feelings in them. This sensation most often occurs in the evening, especially when attempting to relax or sleep. Movement can provide temporary relief, but the impulses may consistently return. Fatigue caused by disrupted sleep may develop that eventually impacts normal functioning and quality of life.

The cause of RLS is unknown. A genetic relationship appears to play a role in some people. Conditions such as iron deficiency or iron-deficiency anemia, kidney failure, pregnancy, rheumatoid arthritis, diabetes, and Parkinson's disease seem to be associated with RLS. However, these relationships are not yet confirmed and most people who seek treatment for RLS do not have one of these conditions. Early research suggests that RLS may result from an alteration in the way the brain uses dopamine and how the body uses iron. However, more research is needed to explore these relationships.