CARDIOVASCULAR DISEASE (also see Women’s Health)

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: Eli Lilly
Title describes study.

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: National Institute of Neurological Disorders and Stroke/NIH/DHHS

Division of Research Principal Investigator: Carlos Iribarren, MD, PhD, MPH
Primary Source of Funding: GlaxoSmithKline Company
Description: This study describes the distribution of Lp-LA2 in young adults, its correlation with traditional and new risk factors and its association with coronary artery calcification.

Division of Research Adjunct Principal Investigator: Arthur Klatsky, MD
Primary Source of Funding: Kaiser Permanente Community Benefit Programs
Description: This study examines a defined cohort of predictors, survival, and extent of hospitalization among 2700 persons with heart failure diagnosed from 1978-2000.

Division of Research Site Principal Investigator: Barbara Sternfeld, PhD
Primary Source of Funding: National Health, Lung, and Blood Institute
Description: This study examines cross-sectional and longitudinal relations of androgens and ovarian findings with cardiovascular disease risk factors and subclinical disease.

Division of Research Principal Investigator: Alan S. Go, MD
Primary Source of Funding: The Permanente Medical Group
Title describes study.

Division of Research Principal Investigator: Carlos Iribarren, MD, PhD, MPH
Primary Source of Funding: American Heart Association
Description: This study examines the distribution of a novel risk marker of endothelial function, asymmetric dimethyl-arginine, and its relation to coronary risk factors and subclinical coronary artery disease among young adults enrolled in the Coronary Heart Disease Risk Factors in Young Adults.

Division of Research Principal Investigator: Bette Caan, DrPH
Primary Source of Funding: Sanofi-Aventis Group (aka Sanofi-Synthelabo, Inc)
Description: The goal of this study is to prospectively examine in a large cohort of men how the combination of weight (BMI) and known clinical/behavioral risk factors (hypertension, smoking, dyslipidemia, impaired glucose tolerance, diet, alcohol, physical activity) impact the following endpoints: cardiovascular disease, diabetes, hypertension, depression, musculoskeletal conditions, health care utilization, and health care costs.

Division of Research Principal Investigator: Carlos Iribarren, MD, MPH, PhD
Primary Source of Funding: National Heart, Lung, and Blood Institute
Description: The study evaluates whether baseline and decline in renal function over time are independent predictors of coronary heart disease, stroke, heart failure, and peripheral vascular disease.

Division of Research Principal Investigator: Andrew J. Karter, PhD
Primary Source of Funding: American Diabetes Association
Description: This study assesses whether the diabetes treatment pioglitazone or other diabetes therapies (sulfonylurea, metformin, or insulin use) are associated with an increased risk of congestive heart failure.

Division of Research Principal Investigator: Alan S. Go, MD
Primary Source of Funding: Reynolds Foundation
Description: This study examines the pathophysiology of coronary disease based on genetics and nongenetic risk markers, with the long-term goal of using these genetic risk factors or risk modifiers to improve diagnosis and risk stratification.

Division of Research Principal Investigator: Carlos Iribarren, MD, PhD, MPH
Primary Source of Funding: Kaiser Foundation Research Institute
Description: This study examines whether a baseline endostatin level is a risk factor for the development of cancer and ischemic heart disease.

Division of Research Principal Investigator: Alan S. Go, MD
Primary Source of Funding: Amgen, Inc.
Description: This study examines the independent role of renal insufficiency and anemia on the care and outcomes of chronic heart failure within a large cohort of both hospitalized and ambulatory adults.

Division of Research Site Principal Investigator: Alan S. Go, MD
Primary Source of Funding: National Heart Lung and Blood Institute
Description: This longitudinal cohort study evaluates the epidemiology of nonvalvular atrial fibrillation in ambulatory patients, including assessing warfarin use for stroke prevention; determining rates of stroke and major bleeding events, and ascertaining the clinical and genetic risk factors for ischemic stroke in the setting of atrial fibrillation.

Division of Research Principal Investigator: Alan S. Go, MD
Primary Source of Funding: G.D. Searle
Description: This cohort study of patients hospitalized with heart failure assesses the changing epidemiology, medical and surgical therapies, variation in treatment and clinical outcomes, and identification of modifiable barriers to optimal heart failure care.

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: National Heart, Lung, and Blood Institute/NIH/DHHS
Description: As a sub-contractor to Univ. of Minnesota, we will obtain blood and urine specimens at the CARDIA examination for shipment to Dr. Myron Gross’s laboratory for study related analyses.

Division of Research Principal Investigator: Alan S. Go, MD
Primary Source of Funding: G.D. Searle and Company, Inc.
Description: This cohort study of patients hospitalized with heart failure assesses the changing epidemiology, medical and surgical therapies, variation in treatment and clinical outcomes, and identification of modifiable barriers to optimal heart failure care.

Division of Research Principal Investigator: Carlos Iribarren, MD, PhD, MPH
Primary Source of Funding: National heart Lung, and Blood Institute/NIH/DHHS
Description: The major goals of the study are: 1) to elucidate the factors that determine the risk of developing disability and poor health outcomes among adults with COPD, controlling for degree of pulmonary function impairment; 2) to evaluate the impact of specific functional limitations on the risk of developing disability in daily activities and work among relatively young adults with COPD; 3) also to elucidate the impact of disability on future adverse health outcomes.

Division of Research Site Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: National Institute of Neurological Disorders and Stroke
Description: This study tests the association of potential genetic risk factors with intracranial hemorrhage occurring after the diagnosis of brain arteriovenous malformation in Kaiser Permanente patients.

Division of Research Principal Investigator: Carlos Iribarren, MD, PhD, MPH
Primary Source of Funding: National Institute of Health
Description: Examine the associations of common variation in inflammation/thrombosis genes with intermediate quantitative phenotypes and sub-clinical coronary atherosclerosis in the Coronary Artery Risk Factor Development in Young Adult (CARDIS) Study, a large, bi-racial cohort study.

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: National Heart, Lung, and Blood Institute
Description: This study describes the distribution of coronary heart disease risk factors in a biracial cohort of men and women, and identifies habits, behaviors, and life-styles that are associated with initial levels of risk factors and with the evolution of risk factors.

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: Pfizer, Inc.
Description: This observational study utilizes hospitalization, outpatient, and pharmacy data to determine the incidence of cardiovascular morbidity and mortality patients with COPD.

Adjunct Principal Investigator: S. Claiborne Johnston, MD, MPH, PhD
Primary Source of Funding: American Heart Association
Description: This project aims to produce simple, validated prediction rules for stroke risk after transient ischemic attack.

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: National Institute of Neurological Disorders and Stroke/NIH/DHHS
Description: Determine the trends in the incidence of arteriovenous malformations (AVMs) of the brain and the rate of rebleeding from AVMs.

Division of Research Principal Investigator: Steve Sidney, MD
Primary Source of Funding: Thrasher Research Fund
Description: A retrospective study of children with sickle cell disease (SCD) in the Kaiser Permanente Medical Care Program to determine whether to have rates of utilization of transcranial Doppler screening and transfusion therapy have increased, with a subsequent decline in stroke rates, among children with SCD, and whether this screening is cost-effective.

Division of Research Site Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: Centers for Disease Control and Prevention
Description: This study seeks to determine whether a multimodal secondary prevention intervention is effective at increasing utilization of evidence-based treatment in patients with ischemic stroke.

Division of Research Principal Investigator: Carlos Iribarren, MD, PhD, MPH
Primary Source of Funding: Kaiser Foundation Research Institute
Description: To understand the long-term risks and the population attributable risk percent of cardiovascular outcomes associated with central (abdominal) obesity at different BMI levels.

Division of Research Principal Investigator: Stephen Sidney, MD, MPH
Primary Source of Funding: National Heart, Lung, and Blood Institute
Description: This Coronary Heart Disease Risk Factors in Young Adults ancillary study seeks to understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of obesity, the metabolic syndrome, and sub-clinical CVD.