Breast Cancer

Division of Research Principal Investigator: Laurel Habel, PhD
Primary Source of Funding: Kaiser Foundation Research Institute
Description: Confirm the results of the recent report linking antibiotic use with the incidence of breast cancer using Kaiser Permanente pharmacy and cancer databases.

Division of Research Principal Investigator: Cathy Schaefer, PhD
Primary Source of Funding: National Institute of Child Health and Human Development/NIH/DHHS
Description: Examines perinatal factors and childhood development as potential determinants of mammographic density and breast cancer risk in adult, female members of a large birth cohort.

Division of Research Principal Investigator: Lawrence Kushi, ScD
Primary Source of Funding: National Institutes of Health
Description: This program project continues the Breast Cancer Family Study, with projects including investigations of BRCA1 and BRCA2, estrogen-metabolizing genes, the search for genetic markers of mammographic density, and follow-up of cohort members.

Division of Research Site Principal Investigator: Laurel Habel, PhD
Primary Source of Funding: National Cancer Institute
Description: This project aims to clinical and pathologic factors that can more accurately identify ductal carcinoma in situ patients at high and low risk of a breast cancer recurrence.

Division of Research Principal Investigator: Laurel Habel, PhD
Primary Source of Funding: National Cancer Institute/NIH/DHHS
Description: This will be the largest and most comprehensive study to date on prognostic factors for DICS. Our results will provide information on the natural history of this heterogeneous group of lesions, and in the future may help in the development of individually tailored treatment strategies for patients with DCIS.

Division of Research Site Principal Investigator: M. Michele Manos, PhD, MPH
Primary Source of Funding: National Cancer Institute
Description: This study investigates failures in screening, detection, and follow-up that accounts for the occurrence of cervical cancer and late-stage breast cancer in women.

Division of Research Principal Investigator: Laurel A. Habel, PhD
Primary Source of Funding: National Cancer Institute
Description: Among patients diagnosed with ductal carcinoma in situ from 1990 to 1997and treated with breast-conserving surgery, this study is examining whether mammographic features of the breast at diagnosis predict risk of subsequent ipsilateral breast cancer.

Division of Research Principal Investigator: De-Kun Li, MD, PhD
Primary Source of Funding: National Cancer Institute
Description: This population-based case-control study examines the association of induced abortion with breast cancer risk in Shanghai, China. The study also examines the effect of maternal age, parity, and gestational age at the procedure on the risk of breast cancer.

Division of Research Principal Investigator: Bette Caan, DrPH
Primary Source of Funding: National Cancer Institute
Description: This observational study is examining post treatment behavioral risk factors for recurrence of secondary breast tumors or new primaries.

Division of Research Principal Investigator: Bette Caan, DrPH
Primary Source of Funding: National Cancer Institute
Description: This study builds on the Life After Cancer Epidemiology (LACE) Study cohort of breast cancer survivors. This study follows these women for another four years and focuses on behavioral and medical predictors of recurrence, survival, and quality of life in the permanent survival period and late and long term health effects of cancer therapy.

Division of Research Principal Investigator: Bette Caan, DrPH
Primary Source of Funding: National Cancer Institute
Description: Mammogram films from all invasive breast cancer cases within the Estrogen + Progestin arm of the Women’s Health Initiative (WHI) Clinical Trial will be collected along with three controls for each case from the same population; density change between the initial baseline mammogram after randomization for each participant will be measured.

Division of Research Principal Investigator: Laurel Habel, PhD
Primary Source of Funding: National Cancer Institute
Description: The aims of this multi-site study are to identify factors associated with mammographic density and examines how density changes as women transition through menopause.

Division of Research Principal Investigator: Andy Avins MD, MPH
Primary Source of Funding: National Cancer Institute/NIH/DHHS
Description: To foster research collaborations among basic researchers, clinical investigators and applied researchers affiliated with quality-controlled population-based tumor registries, so as to advance breast cancer screening methods.

Site Principal Investigator: Lisa Herrinton, PhD
Primary Source of Funding: National Cancer Institute
Description: This study provides information on patient-oriented outcomes for women and their health care providers considering prophylactic mastectomy.

Division of Research Principal Investigator: Nancy Gordon, ScD
Primary Source of Funding: Kaiser Permanente Community Benefit Programs
Description: This project examines whether higher observed rates of breast cancer in Marin County versus East Contra Costa County are related to differences in known breast cancer risk factors in the populations.

Division of Research Principal Investigator: Lawrence Kushi, ScD
Primary Source of Funding: National Cancer Institute
Description: This is a prospective cohort study examines lifestyle and genetic factors and their association with breast cancer recurrence and survival.

Division of Research Principal Investigator: Larry Kushi, ScD
Primary Source of Funding: United States Department of Defense
Description: This is a proposed study of the biological, toxicity-related, behavioral, communication, economic, psycho-social, cultural, and molecular genetic factors that can contribute to racial disparities in the referral, receipt, adherence, and response to systemic adjuvant breast cancer therapy

Division of Research Principal Investigator: Laurel Habel, PhD
Primary Source of Funding: Eli Lilly and Company
This study examines use of raloxifene among women with a history of breast cancer, and describes the patient and clinical factors associated with use in this population.

Division of Research Principal Investigator: Andy Avins, MD, MPH
Primary Source of Funding: National Cancer Institute
Description: This project develops a large registry of mammograms, to assess quality of reporting, measure mammographic density, and relates these to various outcomes including breast cancer and osteoporosis.

Division of Research Principal Investigator: Carol P. Somkin, PhD and Louis Fehrenbacher, MD
Primary Source of Funding: Eli Lilly
Description: Multi-site randomized controlled trail that compares the effectiveness of tamoxifen and raloxifene in reducing incidence of invasive breast cancer and their associated side effect among women at high risk for breast cancer.

Division of Research Site Principal Investigators: Carol P. Somkin, PhD and Louis Fehrenbacher, MD
Primary Source of Funding: National Surgical Adjuvant Breast and Bowel Project, National Cancer Institute
Description: This multi-site, randomized controlled trial compares the effectiveness of tamoxifen and raloxifene in reducing incidence of invasive breast cancer and their associated side effects among women at high risk for breast cancer.

Division of Research Site Principal Investigator: Lawrence Kushi, ScD
Primary Source of Funding: National Institute of Environmental Health Sciences
Description: This Center examines the associations of environmental factors with risk of early breast development. The Kaiser Permanente Northern California component consists specifically of a prospective cohort study of young girls, examining environmental, lifestyle, genetic, and social factors and their influence on early puberty.

Division of Research Principal Investigator: Laurie Habel, PhD
Primary Source of Funding: Genomic Health, Inc.
Description: This study examines whether tumor gene expression technologies used on paraffin-embedded tumor tissue can accurately identify node-negative breast cancer patients at high and low risk for subsequent breast cancer death.

Division of Research Site Principal Investigator: Bette J. Caan, DrPH
Primary Source of Funding: National Cancer Institute
Description: This study assesses the efficacy of a low-fat diet on survival after treatment of localized breast cancer.

Division of Research Site Principal Investigator: Bette J. Caan, DrPH
Primary Source of Funding: National Cancer Institute
Description: This study evaluates the effect of a low fat, high fruit and vegetable diet on breast cancer survival and recurrence in women with early stage breast cancer.