Stephen Van Den Eeden, PhD is an epidemiologist at the Division of Research (DOR), Kaiser Permanente Northern California. He also holds a position as Lecturer in the Department of Health Research and Policy, Stanford University School of Medicine.
Dr. Van Den Eeden's current research efforts are primarily focused on the epidemiology of environmental exposures, neurodegenerative diseases, cancer (with a focus on prostate and pancreatic cancer), and benign genitourinary conditions (e.g., benign prostatic hyperplasia, lower urinary tract symptoms, erectile dysfunction, and urinary incontinence).
Environmental studies have included examining the effect of ambient air pollution and cardiovascular diseases, asthma, and chronic obstructive pulmonary disease using time-series and case-crossover approaches. These studies were funded by the US EPA, the California Air Resources Board, the South Coast Air Quality Management District, and Kaiser Foundation Research Institute.
Dr. Van Den Eeden is an Investigator on studies focused on environmental and genetic risks in neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis, or Lou Gehrig's disease. He is also collaborating on epidemiologic studies of restless legs syndrome and dystonia.
In addition, Dr. Van Den Eeden has a suite of studies looking at various aspects of prostate cancer, including a collaborative case-control study to evaluate the efficacy of prostate-specific antigen (PSA) screening in reducing prostate cancer mortality, the validity of self-reported data on screening for prostate cancer, a study of the secular trends in the use of PSA and prostate cancer incidence and mortality, and a study of molecular markers of prostrate cancer survival. He is also a Co-Investigator on the California Men’s Health Study cohort funded by the California Cancer Research Program, which is a prospective cohort study of over 84,000 men..
His research in benign genitourinary conditions include studies of the effect of diabetes on benign prostatic hyperplasia (BPH), lower urinary tract symptoms (LUTS), and erectile dysfunction (ED). Other studies include investigating parturition factors and risk of urinary incontinence and prolapse in women.
Current Positions:
Scientist, Division of Research, Kaiser Permanente Northern California
Lecturer, Department of Health Research and Policy, Stanford University School of Medicine
Current Projects:
Environmental Health Tracking Project
Explaining the Inverse Smoking Relation with Parkinson’s Disease
Genes, Environment and PD: Studies in Four Unique Cohorts
Genetic and Environmental Risks for Amyotrophic Lateral Sclerosis
A Pilot Study of Restless Legs Syndrome
The Epidemiology of Dystonia
Urinary Incontinence: Reproductive and Hormonal Risk Factors
Multi-Center Study of Pancreatic Cancer Etiology
Molecular Epidemiology of Fatal Prostate Cancer
Treatment Choices and Quality of Life in Newly Diagnosed Prostate Cancer
California Men’s Health Study Cohort
Selected Recent Publications:
Van Den Eeden SK, Tanner CM, Bernstein AL, Fross RD, Leimpeter A, Bloch DA, Nelson LM. Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am J Epidemiol 2003;157:1015-22.
Van Den Eeden SK, Ritz B, Cobb K. Measurement and analysis. In: Nelson LM, Tanner CM, Van Den Eeden SK, McGuire V, eds. Neuroepidemiology: From Principles to Practice. New York, NY: Oxford University Press; 2004: chap 3.
Nelson LM, Tanner CM, Van Den Eeden SK, McGuire VM, eds. Neuroepidemiology: From Principles to Practice. New York, NY: Oxford University Press; 2004.
Hall HI, Van Den Eeden SK, Tolsma DD, Rardin K, Thompson T, Sinclair A, Nadel M Testing for prostate and colorectal cancer: Comparison of self-report and medical record audit. Prev Med 2004;39,27-35.
Efird JT, Friedman GD, Sidney S, Klatsky A, Habel LA, Udaltsova NV, Van Den Eeden S, Nelson LM. The risk for malignant primary adult-onset glioma in a large, multiethnic, managed-care cohort: cigarette smoking and other lifestyle behaviors. J Neuro-Oncology 2004;68-57-69.
Weinmann S, Richert-Boe KE, Van Den Eeden SK, Enger SM, Rybicki BA, Shapiro JA, Weiss NS. PSA and DRE screening in relation to prostate cancer mortality: A case-control study. Epidemiology 2005:16, 367-76.
Brown JS, Wessells H, Chancellor MB, Stamm WE, Stapleton AE, Steers WD, Van Den Eeden SK, McVary KT. Urologic outcomes of diabetes. Diabetes Care 2005:28,177-85.
Van Den Eeden SK, Bruce C, Shan J, Glasser MH. Ectopic pregnancy rate and treatment utilization in a large managed care organization. Obstet Gynecol 2005:105,1052-7.
Popat RA Van Den Eeden SK, Tanner CM, McGuire V, Bernstein AL, Bloch DA, Leimpeter AD, Nelson LM. Effect of reproductive factors and postmenopausal hormone use on the risk of Parkinson’s disease. Neurology 2005:65, 383-90.
Chestnut LG, Thayer MA, Lazo JK, Van Den Eeden SK. The economic value of preventing respiratory and cardiovascular hospitalizations. Contemp Econ Policy, Advance Access epublication, October 19, 2005.
Thom DH, Van Den Eeden SK, Ragins AI, Wassel-Fyr C, Vittinghof E, Subak LL, Brown JS. Differences in prevalence of urinary incontinence by race/ethnicity. J Urol 2006;175:259-64.
Fitzgerald MP, Thom DH, Wassel-Fyr C, Subak L, Brubaker L, Van Den Eeden SK, Brown JS; Reproductive Risks for Incontinence Study at Kaiser Research Group. Childhood urinary symptoms predict adult overactive bladder symptoms. J Urol 2006;175:989-93.
Addis IB, Van Den Eeden SK, Wassel-Fyr CL, Vittinghoff E, Brown JS, Thom DH; Reproductive Risk Factors for Incontinence Study at Kaiser Study Group. Sexual activity and function in middle-aged and older women. Obstet Gynecol 2006;107:755-64.
Huang AJ, Thom DH, Kanaya AM, Wassel-Fyr CL, Van Den Eeden SK, Ragins AI, Subak LL, Brown JS. Urinary incontinence and pelvic floor dysfunction in Asian-American women. Am J Obstet Gynecol 2006 [Epub ahead of print].
Varma MG, Brown JS, Creasman JM, Thom DH, Van Den Eeden SK, Beattie MS, Subak LL; Reproductive Risks for Incontinence Study at Kaiser (RRISK) Research Group. Fecal incontinence in females older than aged 40 years: who is at risk? Dis Colon Rectum 2006;49:841-51.
Enger SM, Van Den Eeden SK, Sternfeld B, Loo RK, Quesenberry, Jr CP, Rowell S, Sadler MC, Shaffer DM, Habel LA, Caan BJ. California Men’s Health Study (CMHS): A multiethnic cohort in a managed care setting. BMC Public Health 2006;6:172.
