M. Michele Manos, PhD, MPH, DVM

M. Michele Manos PhD, MPH, DVM, is a Senior Research Scientist at the Division of Research (DOR), Kaiser Permanente Northern California. She serves as the Director of the Kaiser Permanente Viral Hepatitis Registry. Dr. Manos is also an Associate Adjunct Professor, Department of Epidemiology and Biostatistics, University of California, San Francisco. For over 22 years, she has directed both laboratory science as well as epidemiological investigations. She is also a veterinarian, focusing on wildlife and livestock population health.

Dr. Manos’s research areas have included: etiology and prevention of cervical cancer, development of human papillomavirus (HPV) testing technologies, improving cancer screening processes, community-based health asssessments in minority populations, chronic liver disease and viral hepatitis. She has collaborated on diverse issues ranging from women’s health in Afghanistan to zoonotic diseases in marine mammal workers.

Primary Research Interests:

	Chronic liver disease, particularly viral hepatitis B and C
	Trends and causes of liver cancer (hepatocellular carcinoma)
	Infectious diseases at the interfaces between wildlife, domestic animals, and humans
	Emerging vector-borne diseases and human disease sequelae
	Pet safety for children

Selected Publications:

	Manos MM, Gluzman Y. Simian virus 40 large T antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation. Mol Cell Biol 1984;6:1125-33.
	Manos MM, Ting Y, Wright DK, Lewis AJ, Broker TR, Wolinsky SM. The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. Molecular Diagnostics of Human Cancer, Cancer Cells 1989;7:209-14.
	Bauer HM, Ting Y, Greer CE, Chambers JC, Tashiro CJ, Chimera J, Reingold A, Manos MM. Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA 1991;265:472-7.
	Bosch FX, Manos MM, Muñoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV and the IBSCC Study Group. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 1995;87:796-802.
	Rasekh Z, Bauer HM, Manos MM, Iacopino V. Women’s health and human rights in Afghanistan. JAMA 1998;280:449-55.
	Manos MM, Kinney WK, Hurley LB, Sherman ME, Shieh-Ngai J, Kurman RJ, Ransley JE, Fetterman BH, Hartinger JS, McIntosh KM, Pawlick GF, Hiatt RA. Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. JAMA 1999;281:1605-10.
	Manos MM. HPV testing for clarifying borderline cervical cancer smear results. Recent conflicting results highlight the dilemmas of progress. BMJ 2001;322;878-9.
	Manos MM, Leyden WA, Resendez CI, Klein EG, Wilson TL, Bauer HM. A community-based collaboration to assess and improve medical insurance status and access to health care of Latino children. Public Health Rep 2001;116:575-84.
	Zapka JG, Taplin SH, Solberg LI, Manos MM. A framework for improving the quality of cancer care: the case of breast and cervical cancer screening. Cancer Epidemiol Biomarkers Prev 2003;12:4-13.
	Leyden WA, Manos MM, Geiger AM, Weinmann S, Mouchawar J, Bischoff K, Yood MU, Gilbert J, Taplin SH. Cervical cancer in women with comprehensive health care access: attributable factors in the screening process. J Natl Cancer Inst 2005;97:675-83.
	Weston SR, Leyden W, Murphy R, Bass NM, Bell BP, Manos MM, Terrault NA. Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology 2005;41:372-9.
	Zane LT, Leyden WA, Marqueling AM, Manos MM. A population-based analysis of laboratory abnormalities during isotretinoin therapy for acne vulgaris. Arch Dermatol 2006;142:1016-22.
	Yood MU, Quesenberry CP, Guo D, Wells K, Shan J, Sanders L, Skovron ML, Iloeje U, Caldwell C, Manos MM. Incidence of non-Hodgkin’s lymphoma among individuals with chronic hepatitis B virus. Hepatology 2007;46:107-12.
	Yood MU, Quesenberry CP, Guo D, Wells K, Shan J, Sanders L, Skovron ML, Iloeje U, Caldwell C, Manos MM. Incidence of hepatocellular carcinoma among individuals with hepatitis B virus infection identified using an automated data algorithm. J Viral Hepat 2008:15:28-36.
	Manos MM, Leyden WA, Murphy RC, Terrault NA, Bell BP. The limitations of conventionally-derived chronic liver disease mortality rates: results of a comprehensive assessment. Hepatology 2008;47:1150-7.
	Avins AL, Manos MM, Ackerson L, Zhao W, Murphy RC, Levin TR, Watson DJ, Hwang PMT, Replogle A, Levine JG. Hepatic effects of lovastatin exposure in patients with liver disease. A retrospective study. Drug Saf 2008;31:325-34.