Joan C. Lo, MD

Joan C. Lo, MD, is a Physician Scientist at the Division of Research (DOR), Kaiser Permanente, Northern California. She is also an Assistant Professor in the Division of Endocrinology, Department of Medicine at the University of California. Dr. Lo is also a Scholar with the joint UCSF-DOR Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Program.

Dr. Lo’s research interests include polycystic ovary syndrome and associated reproductive and metabolic outcomes; insulin resistance; metabolic syndrome; osteoporosis treatment and outcomes; and endocrine/metabolic disorders associated with renal disease and HIV infection. Dr. Lo’s previous research focused on understanding the metabolic and body composition abnormalities associated with HIV infection and its therapies, including insulin resistance, dyslipidemia, lipodystrophy, and osteopenia.

Current Positions:

	Research Scientist, Division of Research, Kaiser Permanente, Northern California
	Assistant Professor, Division of Endocrinology, Department of Medicine, University of California, San Francisco, CA (San Francisco General Hospital)

Primary Research Interests:

	Polycystic ovary syndrome (PCOS)
	Osteoporosis therapies and outcomes
	Endocrinopathies of chronic kidney disease
	Endocrine/metabolic perturbations in HIV

Current Research Projects:

	Polycystic Ovary Syndrome and Related Health Outcomes
	Bisphosphonates and bone-related outcomes
	Chronic Renal Insufficiency Cohort (CRIC) Study
	Study of Women Across the Nation (SWAN)- Bone Committee

Selected Publications:

	Lo JC, Mulligan K, Tai VW, Algren H, Schambelan M: Buffalo hump in men with HIV-1 infection. Lancet 1998;351:867-70.
	Lo JC, Schwitzgebel VM, Tyrrell JB, Fitzgerald PA, Kaplan SL, Conte FA, Grumbach MM: Normal female infants born of mothers with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab 1999;84:930-36.
	Mulligan K, Grunfeld C, Tai VW, Algren H, Pang M, Chernoff DN, Lo JC, Schambelan M: Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immun Defic Syndr 2000;23:35-43.
	Lo JC, Grumbach MM: Pregnancy outcomes in women with congenital virilizing adrenal hyperplasia. Endocrinol Metab Clin North Am 2001;30:207-29.
	Mulligan K, Tai VW, Algren H, Abrams DI, Patterson N, Leiser RJ, Lo JC, Schambelan M: Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapy. J Acquir Immun Defic Syndr 2001;26:443-8.
	Noor MA, Lo JC, Mulligan K, Schwarz J-M, Halvorsen RA, Schambelan M, Grunfeld C: Metabolic effects of indinavir in healthy HIV-seronegative men. AIDS 2001;15:F11-18.
	Lo JC, Schambelan M: Reproductive function in human immunodeficiency virus infection. J Clin Endocrinol Metab 2001;86:2338-43.
	Lo JC, Mulligan K, Noor MA, Schwarz J-M, Halvorsen RA, Grunfeld C, Schambelan M: The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulation. J Clin Endocrinol Metab 2001;86:3480-7.
	Schwarz J-M, Mulligan K, Lee J, Lo JC, Wen M, Noor MA, Grunfeld C, Schambelan M: Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation. J Clin Endocrinol Metab 2002;87:942-5.
	Noor MA, Seneviratne T, Aweeka FT, Lo JC, Schwarz J-M, Mulligan K, Schambelan M, Grunfeld C. Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: A randomized, placebo-controlled study. AIDS 2002;16:F1-F8.
	Napolitano LA, Lo JC, Gotway MB, Mulligan K, Barbour JD, Schmidt D, Grant RM, Halvorsen RA, Schambelan M, McCune JM. Increased thymic mass and circulating naïve CD4+ T cells counts in HIV-1-infected adults treated with growth hormone. AIDS 2002;16:1103-11.
	Lo JC, Schambelan M. Adrenal, gonadal and thyroid disorders. In: Dolin R, Masur H, Saag MS, eds. AIDS Therapy. 2nd ed. New York, NY: Elsevier Science; 2003.
	Don BR, Schambelan M, Lo JC. Endocrine hypertension. In: Greenspan FR, Gardner DG, eds. Basic and Clinical Endocrinology. 7th ed. Lange Medical Books/McGraw Hill Companies; 2003.
	Hsue PY, Lo JC, Franklin A, Bolger AF, Martin JN, Deeks SG, Waters DD. Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation 2004;109:1603-8.
	Lee G, Seneviratne T, Noor MA, Lo JC, Schwarz J-M, Aweeka FT, Mulligan K, Schambelan M, Grunfeld C. The metabolic effects of lopinavir/ritonavir in HIV-negative men. AIDS 2004;36:645-7.
	Lee GA, Mafong DD, Noor MA, Lo JC, Mulligan K, Schwarz JM, Schambelan M, Grunfeld C. HIV protease inhibitors increase adiponectin levels in HIV-negative men. J Aquir Immune Defic Syndr 2004;36:645-7.
	Lo JC, Mulligan K, Noor MA, Lee GA, Schwarz J-M, Grunfeld C, Schambelan M. The effects of low dose growth hormone in HIV-infected men with fat accumulation. Clin Infect Dis 2004;39:732-5.
	Lo JC, Chertow GM, Go AS, Hsu CY. Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int 2005;67:1047-52.
	Lo JC, Kazemi MR, Hsue PY, Martin JN, Deeks SG, Schambelan M, Mulligan K. The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIVinfection. Clin Infect Dis 2005;41:1335-40.
	Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol 2005;16:2134-40.
	Lo JC, Feigenbaum SL, Yang J, Pressman AR, Selby JV, Go AS. Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome. J Clin Endocrinol Metab 2006; [Epub ahead of print].
	Lo JC, Pressman AR, Omar MA, Ettinger B. Persistence with weekly alendronate therapy among postmenopausal women. Osteoporos Int 2006;17:922-8.
	Go AS, Lo JC. Epidemiology of non-dialysis-requiring chronic kidney disease and cardiovascular disease. Curr Opin Nephrol Hypertens 2006;15:296-302.
	Lee GA, Lo JC, Aweeka F, Schwarz J-M, Mulligan K, Schambelan M, Grunfeld C. Single-dose lopinavir/ritonavir acutely inhibits insulin-mediated glucose disposal in healthy normal volunteers. Clin Infect Dis 2006; 43:658-60.
	Peralta CA, Kurella M, Lo JC, Chertow GM. The metabolic syndrome and chronic kidney disease. Curr Opinion Nephrol Hypertens 2006;15:361-5.
	Lo JC, Feigenbaum SL, Escobar GJ, Yang J, Crites YM, Ferrara A. Increased prevalence of gestational diabetes among women with diagnosed polycystic ovary syndrome. Diabetes Care 2006; 29:1915-17.
	Lo JC, Zhao X, Scuteri A, Brockwell S, Sowers MR. The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlife. Am J Med 2006;119:S69-S78.