Nicola P. Klein, MD, PhD

Nicola P. Klein, MD, PhD, is a Research Scientist at the Division of Research (DOR) and Co-Director of the Kaiser Permanente Vaccine Study Center, Kaiser Permanente, Northern California. She is also an Adjunct Clinical Instructor in the Department of Pediatrics, Lucile Salter Packard Children’s Hospital at Stanford University School of Medicine. Dr. Klein received her MD and PhD degrees at New York University School of Medicine.

Current Positions:

	Research Scientist, Division of Research, Kaiser Permanente, Northern California
	Co-Director, Kaiser Permanente Vaccine Study Center, Kaiser Permanente, Northern California
	Adjunct Clinical Instructor, Department of Pediatrics, Lucile Salter Packard Children’s Hospital at Stanford, Stanford University School of Medicine

Primary Research Interests:

	Vaccine safety and efficacy
	Genetic influences on vaccine responses
	Vaccine responses among at risk populations (premature infants, children with chronic or genetic diseases).

Current Projects:

	Immunization safety in the Neonatal Intensive Care Unit.
	Premature infants’ T cell immune response to vaccines.
	Epidemiologic vaccine safety studies in conjunction with the CDC as part of the Vaccine Safety Datalink (VSD) and Clinical Immunization Safety Assessment (CISA) network.
	Evaluating genomic influences in regard to influenza susceptibility to infection, transmission and vaccine effectiveness.

Recently Completed Projects:

	Evaluating for risk factors for apnea following immunization in the NICU.
	Evaluating for a genetic role in the immune response to the varicella vaccine.
	Assessing parental preferences for a newly developed CDC vaccine information brochure.

Selected Publications:

	Hope TJ, Bond BL, McDonald D, Klein NP, Parslow TG. Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif. J Virol 1991;65:6001-7.
	Hope TJ, Klein NP, Elder ME, Parslow TG. trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes. J Virol 1992;66:1849-55.
	Doria M, Klein N, Lucito R, Schneider RJ. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. 1: EMBO J 1995;14:4747-57.
	Klein NP, Schneider RJ. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol 1997;17:6427-36.
	Klein NP, Bouchard MJ, Wang LH, Kobarg C, Schneider RJ. Src kinases involved in hepatitis B virus replication. EMBO J 1999;18:5019-27.
	Heineman TC, Schleiss M, Bernstein DI, Spaete RR, Yan L, Duke G, Prichard M, Wang Z, Yan Q, Sharp MA, Klein N, Arvin AM, Kemble G. A phase 1 study of 4 live, recombinant human cytomegalovirus Towne/Toledo chimeric vaccines. J Infect Dis 2006;193:1350-60.
	Klein NP, Holmes TH, Sharp MA, Heineman TC, Schleiss MR, Bernstein DI, Kemble G, Arvin AM, Dekker CL. Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults. Vaccine 2006;24:5913-8.
	Klein NP, Fireman B, Enright A, Ray P, Black S, Dekker CL, for the Clinical Immunization Safety Assessment Network. A role for genetics in the immune response to the varicella vaccine. Pediatr Infect Dis J 2007;26:300-5.
	Black S, France EK, Isaacman D, Bracken L, Lewis E, Hansen J, Fireman B, Austrian R, Graepel J, Gray S, Klein NP. Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal vaccine (PCV-7). Pediatr Infect Dis J 2007;26:771-7.
	Klein NP, Massolo M, Greene J, Dekker CL, Black S, Escobar G, for the Vaccine Safety Datalink. Risk factors for developing apnea after immunization in the neonatal intensive care unit. Pediatrics 2008;121:463-9.
	Black S., Friedland LR., Ensor K, Weston WM., Howe B, Klein NP. Diphtheria-tetanus-acellular pertussis and inactivated poliovirus vaccines given separately or combined for booster dosing at 4 to 6 years of age. Pediatr Infect Dis J 2008, in press.