Carlos Iribarren, MD, MPH, PhD

Carlos Iribarren MD, MPH, PhD, has been a Research Scientist at the Division of Research, Kaiser Permanente, Northern California, since 1997, and an Adjunct Assistant Professor at the Department of Epidemiology and Biostatistics, University of California, San Francisco, since 1998. He was a Fulbright Fellow at the University of Southern California, Los Angeles, from 1989 through 1994. Dr. Iribarren is a clinical epidemiologist, a current member of the American Heart Association Behavioral Science, Epidemiology and Prevention Study Section, and a Consultant for the Health Care Advisors.

Dr. Iribarren has published 36 peer-reviewed articles (first author of 30) ranging from the health consequences of low blood cholesterol, body weight change and fluctuations, or cigar smoking to the prognosis of calcification of the aortic arch, hostility and coronary calcification, and heart failure in diabetes. His current research interests are genetic determinants of coronary disease, inflammation and endothelial dysfunction, and psychosocial factors in coronary disease.

Current Positions:

	Research Scientist, Division of Research, Kaiser Permanente, Northern California
	Adjunct Assistant Professor, Department of Epidemiology and Biostatistics, University of California, San Francisco

Primary Research Interests:

	Cardiovascular epidemiology
	Genetic determinants of coronary heart disease
	Vascular calcification
	Psychosocial factors in coronary disease
	Smoking-related diseases
	Inflammation and endothelial function
	Congestive heart failure in diabetes

Current Projects:

	A Nested Case-Control Study of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) and Subclinical Cardiovascular Disease Among Young Adults
	Asymmetric Dimethyl-Arginine (ADMA), Coronary Risk Factors and Subclinical Disease in Young Adults
	Effects of Exposure to Secondhand Smoke
	Environmental Tobacco Smoke and Exposure and Adult Asthma
	Genetic Epidemiology of Atherosclerotic Heart Disease: Advanced Strategies for Prevention and Therapy

Completed Research Projects (partial listing):

	Low blood cholesterol in an aging cohort
	Glycemic Control and Congestive Heart Failure Among Diabetics Over 20 Years Old
	Liver Function in Asthma

Selected Publications:

	Iribarren C, Reed DM, Wergowske G, Burchfiel CM, Dwyer JH. Serum cholesterol and mortality due to suicide and trauma in the Honolulu Heart Program. Arch Intern Med 1995;155:695-700.
	Iribarren C, Reed DM, Burchfiel CM, Dwyer JH. Serum total cholesterol and mortality: confounding factors and risk modification in Japanese-American men. JAMA 1995;273:1926-32.
	Iribarren C, Sharp DS, Burchfiel CM, Petrovitch H. Association of weight loss and fluctuation with mortality among Japanese-American men. N Eng J Med 1995;333:686-92.
	Iribarren C, Reed DM, Yano K, Chen R, Dwyer JH. Low cholesterol and mortality: which is the cause and which is the effect? Circulation 1995;92:2396-2403.
	Iribarren C, Sharp DS, Burchfiel CM, Dwyer JH. Association of serum total cholesterol with coronary disease and all-cause mortality: multivariate correction for bias due to measurement error. Am J Epidemiol 1996;143:463-71.
	Iribarren C, Sharp DS, Curb JD, Yano K. High uric acid: a metabolic marker of advanced coronary heart disease among alcohol abstainers? J Clin Epidemiol 1996;49:673-8.
	Iribarren C, Folsom AF, Eckfeldt JH, McGovern PG, Nieto JF. Correlates of uric acid and its association with asymptomatic carotid atherosclerosis: the ARIC study. Ann Epidemiol 1996;6:331-40.
	Iribarren C, Belcher JD, Jacobs DR Jr., Gross MD, Schreiner P, Sidney S. Relationship of lipoproteins, apolipoproteins, triglycerides, and lipid ratios to plasma total cholesterol: the CARDIA study. J Cardiovasc Risk 1996;3:391-6.
	Iribarren C, Jacobs DR Jr., Sidney S, Sadler M, Claxton AJ, Tekawa I. Low total serum cholesterol and intracerebral hemorrhagic stroke: is the association confined to elderly men? The Kaiser Permanente Medical Care Program. Stroke 1996;27:1993-8.
	Iribarren C, Folsom AR, Jacobs DR Jr., Gross MD, Belcher JD, Eckfeldt JH. Serum antioxidant vitamins, LDL susceptibility to oxidation, autoantibody against oxidized LDL, and asymptomatic carotid atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17:1171-7.
	Jacobs DR Jr, Hebert B, Schreiner PJ, Sidney S, Iribarren C, Hulley S. Reduced cholesterol is associated with recent illness in young adults: the CARDIA study. Am J Epidemiol 1997;146:558-64.
	Iribarren C, Luepker RV, McGovern PG, Arnett DK, Blackburn H. Twelve-year trends in cardiovascular disease risk factors: are socioeconomic differences widening? The Minnesota Heart Survey. Arch Intern Med 1997;157:873-81.
	Iribarren C, Jacobs DR Jr., Slattery ML, Liu K, Sidney S, Hebert BJ, Roseman J. Epidemiology of low plasma cholesterol concentration in young adults: the CARDIA study. Prev Med 1997;26:495-507.
	Iribarren C, Dwyer JH. Serum total cholesterol, stroke and all-cause mortality: lessons from the Honolulu Heart Program. Nutr Metab Cardiovasc Dis 1997;7:169-74.
	Iribarren C, Jacobs DR Jr, Sidney S, Claxton AJ, Gross MD, Sadler M, Blackburn H. Serum total cholesterol and risk of hospitalization and death from respiratory diseases. Int J Epidemiol 1997;26:1191-1202.
	Iribarren C, Folsom AR, Jacobs DR Jr, Gross MD, Eckfeldt JH, Kritchevsky SB. Patterns of covariation of serum b-carotene and a-tocopherol in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study. Nutr Metab Cardiovasc Dis 1997;7:445-58.
	Iribarren C, Sempos CT, Eckfeldt JH, Folsom AR. Lack of a association between serum ferritin and measures of LDL oxidation: the ARIC study. Atherosclerosis 1998;139:189-95.
	Claxton AJ, Jacobs DR Jr, Iribarren C, Welles SL, Sidney S, Feingold KR. The association between serum total cholesterol and HIV infection in a high risk cohort of young men. J Acquir Immune Defic Syndr Hum Retrovirol 1998;17:51-7.
	Iribarren C, Crow R, Hannan P, Jacobs DR Jr, Luepker RV. Validation of death certificate diagnosis of out of hospital sudden cardiac death. Am J Cardiol 1998;82:50-3.
	Iribarren C, Jacobs DR Jr, Sidney S, Claxton AJ, Feingold KR. Cohort study of serum cholesterol and in-hospital incidence of infectious diseases. Epidemiol Infect 1998;121:335-47.
	Iribarren C, Lowry PW, Gross MD, Jacobs DR Jr. Influence of total serum cholesterol and lipid-soluble vitamins in immune response among healthy young adults. Environmental Nutrition Interactions 1998;2:127-38.
	Iribarren C, Sidney S, Tekawa IS, Friedman GD. Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary diesase, and cancer in men. N Eng J Med 1999;340:1773-80.
	Nieto FJ, Iribarren C, Gross MD, Constock GW, Cutler R. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis 1999;148:131-9.
	Iribarren C, Jacobs Jr. DR, Sidney S, Gross MD, Eisner MD. Cigarette smoking, alcohol consumption, and risk of ARDS: a 15-year prospective study in a managed care setting. Chest 2000;117:163-8.
	Iribarren C. Reexamining health effects of cigar smoking: fashionable, but may increase the risk of coronary heart disease. Eur Heart J 2000;21:505-6.
	Iribarren C, Sidney S, Liu K, Markovitz JH, bild DE, Roseman JM, Mathews K. Hostility is associated with coronary artery calcification in young adults: the CARDIA Study. JAMA 2000;283:2546-51.
	Iribarren C, Sidney S, Sternfeld B, Browner WS. Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral arterial disease. JAMA 2000;283:2810-15.
	Moriarity JT, Folsom AR, Iribarren C, Nieto FJ, Rosamond WD. Serum uric acid and risk of coronary heart disease: Atherosclerosis Risk in Communities (ARIC) Study. Ann Epidemiol 2000;10:136-143.
	Iribarren C, Sidney S, Jacobs Jr DR, Weisner C. Hospitalization for suicide attempt and completed suicide: epidemiological features in a managed care population. Soc Psychiatry Psychiatr Epidemiol 2000;35:288-96.
	Iribarren C, Sidney S, Lydick E, Sorel ME, Eisner MD. The association between asthma, asthma medication use, and hepatic enzyme elevation among adult HMO members. Comp Ther 2001;27:133-9.
	Iribarren C, Karter AJ, Go AS, Ferrara A, Liu JY, Sidney S, Selby JV. Glycemic control and heart failure among adult patients with diabetes. Circulation 2001;103:2668-73.
	Iribarren C, Haselkorn T, Tekawa I, Friedman GD. Cohort study of thyroid cancer in a San Francisco Bay Area population. Int J Cancer 2001;93:745-50.
	Iribarren C, Friedman GD, Klatsky AL, Eisner MD. Exposure to environmental tobacco smoke: association with personal character reported health conditions. J Epidemiol Community Health 2001;55(10):721-8.
	Iribarren C, Haselkorn T, Tekawa IS, Friedman GD. Cohort study of thyroid cancer in a San Francisco Bay area population. Int J Cancer 2001;93:745-50.
	Iribarren C. Does poor glycemic control predict heart failure in diabetics? Cardiol Rev 2002;19:27-30.
	Iribarren C, Markovitz JH, Jacobs DR, Schreiner PJ, Daviglus M, Hibbeln JR. Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults--the CARDIA Study. Eur J Clin Nutr 2004;58:24-31.
	Iribarren C, Jacobs DR, Kiefe CI, Lewis CE, Matthews KA, Roseman JM, Hulley SB. Causes and demographic, medical, lifestyle and psychosocial predictors of premature mortality: the CARDIA study. Soc Sci Med. 2005 Feb; 60(3):471-482.
	Iribarren C, Gross MD, Darbinian JA, Jacobs Jr DR, Sidney S, Loria C. Association of Lipoprotein-Associated Phospholipase A2 Mass and Activity With Calcified Coronary Plaque in Young Adults. The CARDIA Study. Arterioscler Thromb Vasc Biol. 2004 Oct 21 [Epub ahead of print]
	Eisner MD, Boland M, Tolstykh I, Mendoza G, Iribarren C. Intensive care unit admission for asthma: a marker for severe disease. J Asthma. 2005 Jun;42(5):315-23.
	Erickson S, Tolstykh I, Selby JV, Mendoza G, Iribarren C, Eisner MD. The impact of allergy and pulmonary specialist care on emergency asthma utilization in a large managed care organization. Health Serv Res. 2005 Oct;40(5 Pt 1):1443-65.
	Iribarren C, Tolstykh I, Somkin CP, Ackerson LM, Brown TT, Scheffler R, Syme L,Kawachi I. Sex and racial/ethnic disparities in outcomes after acute myocardial infarction: a cohort study among members of a large integrated health care delivery system in northern California. Arch Intern Med. 2005 Oct 10;165(18):2105-13.
	Hall YN, Hsu CY, Iribarren C, Darbinian J, McCulloch CE, Go AS. The conundrum of increased burden of end-stage renal disease in Asians. Kidney Int. 2005 Nov;68(5):2310-6.
	Iribarren C, Tolstykh I, Somkin CP, Ackerson LM, Brown TT, Scheffler R, Syme L, Kawachi I. Sex and racial/ethnic disparities in outcomes after acute myocardial infarction: a cohort study among members of a large integrated health care delivery system in Northern California. Arch Intern Med 2005;165:2105-13.
	Eisner MD, Klein J, Hammond SK, Koren G, Lactao G, Iribarren C. Directly measured second hand smoke exposure and asthma health outcomes. Thorax 2005;60:814-21.
	Hall YN, Hsu CY, Iribarren C, Darbinian J, McCulloch CE, Go AS. The conundrum of increased burden of end-stage renal disease in Asians. Kidney Int 2005;68:2310-6.
	Iribarren C. Lipoprotein-associated phospholipase A2 and cardiovascular risk: state of the evidence and future directions. Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):5-6.
	Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006 Jan 3;144(1):21-8.
	Hozawa A, Houston T, Steffes MW, Widome R, Williams OD, Iribarren C, Pletcher MJ, Daviglus ML, Carr JJ, Jacobs DR Jr. The association of cigarette smoking with self-reported disease before middle age: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Prev Med. 2006 Feb 7; [Epub ahead of print]
	Go AS, Iribarren C, Chandra M, Lathon PV, Fortmann SP, Quertermous T, Hlatky MA; Atherosclerotic Disease, Vascular Function and Genetic Epidemiology (ADVANCE) Study. Statin and beta-blocker therapy and the initial presentation of coronary heart disease. Ann Intern Med. 2006 Feb 21;144(4):229-38.
	Knox S, Barnes A, Kiefe C, Lewis CE, Iribarren C, Matthews KA, Wong ND, Whooley M. History of Depression, Race, and Cardiovascular Risk in CARDIA. Int J Behav Med. 2006;13(1):44-50.
	Houston TK, Houston TK, Person SD, Pletcher MJ, Liu K, Iribarren C, Kiefe CI. Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study. BMJ. 2006 Apr 7; [Epub ahead of print]
	Iribarren C, Herrinton LJ, Darbinian JA, Tamarkin L, Malinowski D, Vogelman JH, Orentreich N, Baer D. Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race? Vasc Med. 2006 Feb;11(1):13-20.
	Iribarren C, Herrinton LJ, Darbinian JA, Tamarkin L, Malinowski D, Vogelman JH, Orentreich N, Baer D. Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race? Vasc Med 2006;11:13-20.
	Houston TK, Person SD, Pletcher MJ, Liu K, Iribarren C, Kiefe CI. Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study. BMJ 2006;332:1064-9.