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Research

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Vaccine Epidemiology

Through the Vaccine Study Center and the numerous studies at the Division of Research, Kaiser Permanente is a national leader in vaccine research. Our researchers lead work on a wide variety of vaccines and study safety, effectiveness, cost and policy.

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Evaluation of Novel H1N1 Influenza A Virus Infection and Vaccine Effectiveness among Pregnant Women, a High Risk Population Prioritized for Early Receipt of Vaccine

1. Estimate the effectiveness of vaccines for prevention of H1N1 infenction among pregnant women. 2. Examine the effect H1N1 infection on pregnancy outcomes. 3. Estimate vertical transmission of H1N1 infection 4. Examine the modifying factors for H1N1 effect on pregnant women 5. Follow up infant status by H1N1 infected women.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Li, De-Kun

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A Phase IIIb, Open-Label, Controlled, Multi-Center Study to Evaluate the Persistence of Antibody Responses Among Children who Previously Received Novartis MenACWY Conjugate Vaccine (Novartis Protocol V59P14E1)

Funder: Novartis
Principal Investigator: Klein, Nicola

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Pregnancy Outcome Following Immunization with Trivalent Influenza Vaccine in Early Pregnancy (Vaccine Safety Fellowship Program)

To support the fellowship of Dr. Ali Rowhani-Rahbar.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Rowhani-Rahbar, Ali

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Evaluating the Effectiveness of a 13-Valent Pneumococcal Conjugate Vaccine among Children

Funder: Centers for Disease Control and Prevention
Principal Investigator: Baxter, Roger

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HPV-Related Outcomes in Kaiser Permanente Patients: Trends Following Vaccine Dissemination

This study’s objective is to provide periodic population-based estimates of prespecified HPV-related clinical outcomes following the licensing and dissemination of the HPV vaccine.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Silverberg, Michael

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A Phase 3b, Open-Label, Randomized, Parallel-Group, Multicenter Study to Evaluate the Safety of Novartis Men ACWY Conjugate Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants

Funder: Novartis
Principal Investigator: Klein, Nicola

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Phase III, Partially Double-Blind Study to Evaluate Consistency and Immunogenicity of 3 Lots of GSK Biologicals’ Hib Conjugate Vaccine 208108 Versus ActHIB and Pentacel at 2, 4, 6 and 15-18 Months of Age in Healthy Infants

Funder: GlaxoSmithKline
Principal Investigator: Klein, Nicola

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Surveillance for Invasive Pneumococcal Disease (IPD) and Serotype Replacement in the Ten Years Following Introduction of the Pneumococcal Conjugate Vaccine

Title defines the study.
Funder: Wyeth-Lederle
Principal Investigator: Baxter, Roger

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Immune Thrombocytopenic Purpura (ITP) After Childhood Vaccines

A collaborative study with several HMOs to provide an analysis of vaccine adverse events.
Funder: Food and Drug Administration
Principal Investigator: Baxter, Roger

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An Economic Analysis of Pneumococcal Conjugate Vaccine: An Update

This project revises a previously developed economic model of the pneumococcal conjugate vaccine to incorporate more recent national data on the "herd" effects of the vaccine.
Funder: Wyeth-Lederle
Principal Investigator: Ray, G. Thomas

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Immunogenicity and Safety of a New Meningococcal Conjugate Vaccine Administered to Two to 10 year olds

Funder: Novartis
Principal Investigator: Klein, Nicola

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Post-Licensure Safety Surveillance Study of Routine Use of Pentacel

Funder: Sanofi Pasteur
Principal Investigator: Klein, Nicola

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Post-licensure Safety Surveillance Study of Routine Use of Meningococcal (Groups A, C, Y, and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra) in Recipients Two to 10 Years of Age

Funder: Sanofi Pasteur
Principal Investigator: Klein, Nicola

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A Post-licensure Surveillance Program for the Safety of GARDASIL in a Managed Care Organization Setting

Funder: Merck and Co., Inc.
Principal Investigator: Klein, Nicola

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Vaccine Safety Databank Evaluation of Human Papilloma Virus Associated Outcomes

Funder: Centers for Disease Control and Prevention
Principal Investigator: Klein, Nicola

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Safety and Immunogenicity of a Novel Quadrivalent Meningococcal CRM-Conjugate Vaccine Given Concomitantly With Routine Vaccinations in Infants

Klein, N. P.; Reisinger, K. S.; Johnston, W.; Odrljin, T.; Gill, C. J.; Bedell, L.; Dull, P.;
 
Nov 16 2011
PubMed abstract  »

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Lack of association between childhood immunizations and encephalitis in California, 1998-2008

Pahud, B. A.; Rowhani-Rahbar, A.; Glaser, C.; Gavali, S.; Salibay, C. J.; Fireman, B.; Dekker, C. L.;
Vaccine  
Nov 10 2011
PubMed abstract  »

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Safety of Zoster Vaccine in Adults from a Large Managed Care Cohort: A Vaccine Safety Datalink Study

Tseng, H. F.; Liu, A.; Sy, L.; Marcy, S. M.; Fireman, B.; Weintraub, E.; Baggs, J.; Weinmann, S.; Baxter, R.; Nordin, J.; Daley, M. F.; Jackson, L.; Jacobsen, S. J.;
 
Oct 25 2011
PubMed abstract  »

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Surveillance of Autoimmune Conditions following Routine Use of Quadrivalent Human Papillomavirus Vaccine

Chao, C.; Klein, N. P.; Velicer, C. M.; Sy, L. S.; Slezak, J. M.; Takhar, H.; Ackerson, B.; Cheetham, T. C.; Hansen, J.; Deosaransingh, K.; Emery, M.; Liaw, K. L.; Jacobsen, S. J.;
 
Oct 4 2011
PubMed abstract  »

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Monitoring the safety of quadrivalent human papillomavirus vaccine: Findings from the Vaccine Safety Datalink

Gee, J.; Naleway, A.; Shui, I.; Baggs, J.; Yin, R.; Li, R.; Kulldorff, M.; Lewis, E.; Fireman, B.; Daley, M. F.; Klein, N. P.; Weintraub, E. S.;
Vaccine  
Sep 7 2011
PubMed abstract  »

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Causality assessment of serious neurologic adverse events following 2009 H1N1 vaccination

Williams, S. E.; Pahud, B. A.; Vellozzi, C.; Donofrio, P. D.; Dekker, C. L.; Halsey, N.; Klein, N. P.; Baxter, R. P.; Marchant, C. D.; Larussa, P. S.; Barnett, E. D.; Tokars, J. I.; McGeeney, B. E.; Sparks, R. C.; Aukes, L. L.; Jakob, K.; Coronel, S.; Sejvar, J. J.; Slade, B. A.; Edwards, K. M.;
Vaccine  
Sep 2 2011
PubMed abstract  »

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Underimmunization at discharge from the neonatal intensive care unit

Navar-Boggan, A. M.; Halsey, N. A.; Escobar, G. J.; Golden, W. C.; Klein, N. P.;
J Perinatol  
Aug 11 2011
PubMed abstract  »

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Safety of trivalent inactivated influenza vaccine in children aged 24 to 59 months in the vaccine safety datalink

Glanz, J. M.; Newcomer, S. R.; Hambidge, S. J.; Daley, M. F.; Narwaney, K. J.; Xu, S.; Lee, G. M.; Baggs, J.; Klein, N. P.; Nordin, J. D.; Naleway, A. L.; Belongia, E. A.; Weintraub, E. S.;
Arch Pediatr Adolesc Med  165 (8): 749-55
Aug 2011
PubMed abstract  »

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Overview of the Clinical Consult Case Review of adverse events following immunization: Clinical Immunization Safety Assessment (CISA) network 2004-2009

Williams, S. E.; Klein, N. P.; Halsey, N.; Dekker, C. L.; Baxter, R. P.; Marchant, C. D.; Larussa, P. S.; Sparks, R. C.; Tokars, J. I.; Pahud, B. A.; Aukes, L.; Jakob, K.; Coronel, S.; Choi, H.; Slade, B. A.; Edwards, K. M.;
Vaccine  
Jul 27 2011
PubMed abstract  »

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H1N1 and Seasonal Influenza Vaccine Safety in the Vaccine Safety Datalink Project

Lee, G. M.; Greene, S. K.; Weintraub, E. S.; Baggs, J.; Kulldorff, M.; Fireman, B. H.; Baxter, R.; Jacobsen, S. J.; Irving, S.; Daley, M. F.; Yin, R.; Naleway, A.; Nordin, J. D.; Li, L.; McCarthy, N.; Vellozzi, C.; Destefano, F.; Lieu, T. A.;
Am J Prev Med   41 (2): 121-8
Aug 2011
PubMed abstract  »

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Risk of rheumatoid arthritis following vaccination with tetanus, influenza and hepatitis B vaccines among persons 15-59 years of age

Ray, P.; Black, S.; Shinefield, H.; Dillon, A.; Carpenter, D.; Lewis, E.; Ross, P.; Chen, R. T.; Klein, N. P.; Baxter, R.;
Vaccine  
Jul 13 2011
PubMed abstract  »

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Monitoring vaccine safety using the Vaccine Safety Datalink: utilizing immunization registries for pandemic influenza

McCarthy, N. L.; Gee, J.; Weintraub, E.; Donahue, J. G.; Nordin, J. D.; Daley, M. F.; Naleway, A.; Henninger, M.; Baxter, R.; Crane, B.; Aukes, L.; Wagner, N.; Fisher, S.; Jacobsen, S. J.; Sy, L.; Baggs, J.;
Vaccine   29 (31): 4891-6
Jul 12 2011
PubMed abstract  »

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Active Surveillance for Adverse Events: The Experience of the Vaccine Safety Datalink Project

Yih, W. K.; Kulldorff, M.; Fireman, B. H.; Shui, I. M.; Lewis, E. M.; Klein, N. P.; Baggs, J.; Weintraub, E. S.; Belongia, E. A.; Naleway, A.; Gee, J.; Platt, R.; Lieu, T. A.;
Pediatrics  127 (Suppl 1): S54-S64
Apr 18 2011
PubMed abstract  »

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Attitudes and Beliefs of Parents Concerned About Vaccines: Impact of Timing of Immunization Information

Vannice, K. S.; Salmon, D. A.; Shui, I.; Omer, S. B.; Kissner, J.; Edwards, K. M.; Sparks, R.; Dekker, C. L.; Klein, N. P.; Gust, D. A.;
Pediatrics  127 (Suppl 1): S120-6
May 2011
PubMed abstract  »

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Understanding the Role of Human Variation in Vaccine Adverse Events: The Clinical Immunization Safety Assessment Network

Larussa, P. S.; Edwards, K. M.; Dekker, C. L.; Klein, N. P.; Halsey, N. A.; Marchant, C.; Baxter, R.; Engler, R. J.; Kissner, J.; Slade, B. A.;
Pediatrics  127 (Suppl 1): S65-S73
May 2011
PubMed abstract  »