Clinical Prediction of Hepatotoxicity & Comparative Hepatic Safety of Medications
Evaluation of Hy's Rule for hepatotoxicity
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Corley, Douglas
Observational Post-Authorization Study of Patients Treated With Raltegravir
The purpose of this study is to assess the phase IV safety of raltegravir, an integrase inhibitor recently released for use as an HIV antiretroviral medication, in the course of ordinary clinical practice in Kaiser Permanente Northern and Southern California.
Funder: Merck and Co., Inc.
Principal Investigator: Horberg, Michael
Data Mining Electronic Health Records for Drug Adverse Events
When a new pharmaceutical drug enters the market, there are always questions about its effectiveness and safety profile in comparison with other related drugs; this project will use two data mining methods (the tree-based scan statistic and Bayesian gamma Poisson shrinkage) to search for unexpected drug adverse events.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Herrinton, Lisa
TZD-Fibrate Feasibility Study
This proposal will explore the feasibility of a study to determine if combined use of a thiazolidinedione (PPAR- agonist) and a fibrate (PPAR- agonist) increase cardiovascular risk compared to thiazolidinedione use without fibrate.
Funder: Food and Drug Administration
Principal Investigator: Habel, Laurel
Propoxyphene Feasibility Study
The aim of this study is to explore the feasibility of a retrospective cohort study to evaluate the use of propoxyphene products in U.S. populations and the risk of death, fall-related fractures, and cardiotoxicity in new users of propoxyphene compared to new users of codeine and tramadol.
Funder: Food and Drug Administration
Principal Investigator: Habel, Laurel
The Relationship Between Opioid Drug, Total Daily Dose, Duration of Action and Testosterone Levels in Men With Chronic Pain
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Rubinstein, Andrea
Medication Adherence and Social Disparities in Diabetes
This study will evaluate whether diabetes, blood pressure, and cholesterol medications are taken by patients with diabetes as prescribed (“adherence”), emphasizing social patterns in adherence, clinical consequences, and reasons for differences in therapy initiation, maintenance, and discontinuation.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Karter, Andrew
Pharmaceuticals & Cancer (renewal)
The primary aim of this study is to continue surveillance of more than 200 of the most commonly prescribed drugs for carcinogenicity, as well as to examine selected drug-cancer associations of potential importance.
Funder: National Cancer Institute
Principal Investigator: Habel, Laurel
Building a Population Laboratory for Pharmaco-epidemiologic and Pharmacogenomic Studies in Cancer: Cardiotoxicity following Chemotherapy for Breast Cancer:
The primary aims of this project are to develop an infrastructure that will allow researchers to assess the validity of electronic data on chemotherapy infusion, including route of administration, drug and dosage in each participating site, and also to increase the availability and validity of electronic chemotherapy data among those sites with incomplete or inaccurate data.
Funder: National Cancer Institute
Principal Investigator: Habel, Laurel
Combined Hormonal Contraceptive (CHC) Drugs: Thromboembolic Disease and Death Outcomes
This study evaluates use of OE, Yasmin, the NuvaRing and comparator contraceptive product(s) in a population of new users (incident cohort) to assess the public health impact, patterns of use, and eventually, the behavioral and environmental factors related to use that could place a woman at greater risk for a thromboembolic event and/or death.
Funder: Food and Drug Administration
Principal Investigator: Sidney, Stephen
Medications for ADHD and Risk of Serious Cardiovascular Disease in Adults: Addition of Stroke Endpoint
This study examines the risk of stroke associated with medications used to treat ADHD.
Funder: Food and Drug Administration
Principal Investigator: Habel, Laurel
Building a Population Laboratory for Pharmaco-epidemiologic and Pharmacogenomic Studies in Cancer: Cardiotoxicity Following Chemotherapy for Breast Cancer
This study aims to identify a cohort of patients with incident invasive breast cancer, and use the VDW and other electronic data sources to determine for each member of the cohort, among other things, the presence or absence of heart disease and other co-morbidities at the time of cancer diagnosis.
Funder: National Cancer Institute
Principal Investigator: Habel, Laurel
Patterns of Use of Biologic Drugs in Immune-mediated Disease
This study assesses whether elders have adequate and appropriate access to biologic agents for the treatment of their rheumatoid arthritis, and illuminates the reasons for under-use and suboptimal selection of these agents.
Funder: Genentech
Principal Investigator: Herrinton, Lisa
Risk of Cancer in Patients Exposed to Buproprion
This multi-site nested case-control study compares risk of cancer (prostate, breast, lung, colon/rectum, bladder, uterus) in users of buproprion to that in users of other antidepressants.
Funder: GlaxoSmithKline
Principal Investigator: Quesenberry, Charles
HMORN Centers for Education and Research Therapeutics (CERT3): Infrastructure
This funding allows for the creation and maintenance of an infrastructure to support research and education on therapeutics among nine participating members of the HMO Research Network. The projects conducted to date range from drug safety assessments to the impact of drug copayments on patients with diabetes.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Herrinton, Lisa
Changes in cotherapies after initiation of disease-modifying
antirheumatic drug therapy in patients with rheumatoid arthritis
Kawai, V. K.;
Grijalva, C. G.;
Arbogast, P. G.;
Curtis, J. R.;
Solomon, D. H.;
Delzell, E.;
Chen, L.;
Ouellet-Hellstrom, R.;
Herrinton, L.;
Liu, L.;
Mitchel, E. F., Jr.;
Stein, C. M.;
Griffin, M. R.;
Arthritis Care Res
63
(10):
1415-24
Oct 2011
PubMed abstract
»
Non-Steroidal Anti-Inflammatory Drug Use Reduces Risk for
Adenocarcinomas of the Esophagus and Esophagogastric Junction in a
Pooled Analysis
Liao, L. M.;
Vaughan, T. L.;
Corley, D. A.;
Cook, M. B.;
Casson, A. G.;
Kamangar, F.;
Abnet, C. C.;
Risch, H. A.;
Giffen, C.;
Freedman, N. D.;
Chow, W. H.;
Sadeghi, S.;
Pandeya, N.;
Whiteman, D. C.;
Murray, L. J.;
Bernstein, L.;
Gammon, M. D.;
Wu, A. H.;
Gastroenterology
Nov 18 2011
PubMed abstract
»
Antipsychotic Medication Use Among Children and Risk of Diabetes
Mellitus
Andrade, S. E.;
Lo, J. C.;
Roblin, D.;
Fouayzi, H.;
Connor, D. F.;
Penfold, R. B.;
Chandra, M.;
Reed, G.;
Gurwitz, J. H.;
Pediatrics
Nov 21 2011
PubMed abstract
»
Population-based study of erectile dysfunction and polypharmacy
Londono, D. C.;
Slezak, J. M.;
Quinn, V. P.;
Van Den Eeden, S. K.;
Loo, R. K.;
Jacobsen, S. J.;
BJU international
Nov 15 2011
PubMed abstract
»
Initiation of Tumor Necrosis Factor-alpha Antagonists and the Risk
of Hospitalization for Infection in Patients With Autoimmune
Diseases
Grijalva, C. G.;
Chen, L.;
Delzell, E.;
Baddley, J. W.;
Beukelman, T.;
Winthrop, K. L.;
Griffin, M. R.;
Herrinton, L. J.;
Liu, L.;
Ouellet-Hellstrom, R.;
Patkar, N. M.;
Solomon, D. H.;
Lewis, J. D.;
Xie, F.;
Saag, K. G.;
Curtis, J. R.;
Nov 6 2011
PubMed abstract
»
ADHD Drugs and Serious Cardiovascular Events in Children and Young
Adults
Cooper, W. O.;
Habel, L. A.;
Sox, C. M.;
Chan, K. A.;
Arbogast, P. G.;
Cheetham, T. C.;
Murray, K. T.;
Quinn, V. P.;
Stein, C. M.;
Callahan, S. T.;
Fireman, B. H.;
Fish, F. A.;
Kirshner, H. S.;
O'Duffy, A.;
Connell, F. A.;
Ray, W. A.;
Nov 1 2011
PubMed abstract
»
Role of Thiopurine and Anti-TNF Therapy in Lymphoma in Inflammatory
Bowel Disease
Herrinton, L. J.;
Liu, L.;
Weng, X.;
Lewis, J. D.;
Hutfless, S.;
Allison, J. E.;
Oct 25 2011
PubMed abstract
»
Statin Use During Ischemic Stroke Hospitalization Is Strongly
Associated With Improved Poststroke Survival
Flint, A. C.;
Kamel, H.;
Navi, B. B.;
Rao, V. A.;
Faigeles, B. S.;
Conell, C.;
Klingman, J. G.;
Sidney, S.;
Hills, N. K.;
Sorel, M.;
Cullen, S. P.;
Johnston, S. C.;
Oct 20 2011
PubMed abstract
»
Re: A Case-Control Study of Levothyroxine and the Risk of
Colorectal Cancer
Friedman, G. D.;
Schwalbe, J. S.;
Habel, L. A.;
Oct 18 2011
PubMed abstract
»
Maternal exposure to angiotensin converting enzyme inhibitors in
the first trimester and risk of malformations in offspring: a
retrospective cohort study
Li, D. K.;
Yang, C.;
Andrade, S.;
Tavares, V.;
Ferber, J. R.;
BMJ
343
d5931 (10p)
2011
PubMed abstract
»
Medication Exposure in Pregnancy Risk Evaluation Program
Andrade, S. E.;
Davis, R. L.;
Cheetham, T. C.;
Cooper, W. O.;
Li, D. K.;
Amini, T.;
Beaton, S. J.;
Dublin, S.;
Hammad, T. A.;
Pawloski, P. A.;
Raebel, M. A.;
Smith, D. H.;
Staffa, J. A.;
Toh, S.;
Dashevsky, I.;
Haffenreffer, K.;
Lane, K.;
Platt, R.;
Scott, P. E.;
Oct 15 2011
PubMed abstract
»
Contribution of Common Medications to Lower Urinary Tract Symptoms
in Men
Wuerstle, M. C.;
Van Den Eeden, S. K.;
Poon, K. T.;
Quinn, V. P.;
Hollingsworth, J. M.;
Loo, R. K.;
Jacobsen, S. J.;
171
(18):
1680-1682
Oct 10 2011
PubMed abstract
»
Potential role of differential medication use in explaining excess
risk of cardiovascular events and death associated with chronic
kidney disease: a cohort study
Bansal, N.;
Hsu, C. Y.;
Chandra, M.;
Iribarren, C.;
Fortmann, S. P.;
Hlatky, M. A.;
Go, A. S.;
12
(1):
44(9p)
Sep 14 2011
PubMed abstract
»
Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study
Bansal, N.;
Hsu, C. Y.;
Chandra, M.;
Iribarren, C.;
Fortmann, S. P.;
Hlatky, M. A.;
Go, A. S.;
BMC nephrology
12
(1):
44(9p)
Sep 14 2011
PubMed abstract
»
Study design for a comprehensive assessment of biologic safety
using multiple healthcare data systems
Herrinton, L. J.;
Curtis, J. R.;
Chen, L.;
Liu, L.;
Delzell, E.;
Lewis, J. D.;
Solomon, D. H.;
Griffin, M. R.;
Ouellet-Hellstom, R.;
Beukelman, T.;
Grijalva, C. G.;
Haynes, K.;
Kuriya, B.;
Lii, J.;
Mitchel, E.;
Patkar, N.;
Rassen, J.;
Winthrop, K. L.;
Nourjah, P.;
Saag, K. G.;
Pharmacoepidemiology and Drug Safety
Sep 15 2011
PubMed abstract
»