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Research

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Mental Health

Mental illness affects about one in five families in the US, according to the National Institutes of Health. Our researchers examine the causes and treatment of these disorders as well as the interaction of mental illness with other diseases and its influence on lifestyle choices and health behaviors.  

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Outcomes of Bariatric Surgery among Patients with Bipolar Disorder

This retrospective cohort study will examine bariatric surgery outcomes among 5155 patients (1.6% with bipolar disorder, 30% with major depressive disorder, 68% with no affective disorder) who underwent bariatric surgery between 2006 and 2009 in Kaiser Permanente Northern California.
Funder: National Institute of Mental Health
Principal Investigator: Ahmed, Ameena

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Mental Health Disorders & Medication Adherence & Outcomes in Hypertension, Atrial Fibrillation & Venous Thromboembolism within the CVRN

To examine the relationship between three prevalent mental health disorders (depression, anxiety disorders, and ADHD), their associated therapies, and outcomes for hypertension, atrial fibrillation and venous thromboembolic disease within the NHLBI-sponsored Cardiovascular Research Network (CVRN). These outcomes will include intermediate markers such as medication adherence and surrogate outcomes (e.g., systolic blood pressure and percentage of time spent at a therapeutic INR), as well as long-term clinical outcomes such as thromboembolic events (e.g., acute myocardial infarction, ischemic stroke, recurrent venous thromboembolism) and major bleeding. 
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Go, Alan

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CRN Adminisrative Supplement:Developing a Mental Health Data Resource

To create a mental health research network of 8 provider organizations across the country that will allow collaborative research 
Funder: National Cancer Institute
Principal Investigator: Hunkeler, Enid

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ABC: Antidepressants and Breast Cancer Pharmacoepidemiology

The overarching goal of this project is to investigate the association between the concomitant use of SSRI and tamoxifen and the risk of recurrence or new primary breast cancer.  We propose a population based case-control design nested within a cohort of women diagnosed with early stage hormone receptor positive breast cancer. We plan to assemble large a cohort of women with breast cancer using a SEER-affiliated electronic tumor registry and identify women who developed a recurrence or a new primary breast cancer (cases) & those who remained breast cancer-free (controls). 
Funder: National Cancer Institute
Principal Investigator: Habel, Laurel

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Dementia After Traumatic Brain Injury: A Longitudinal Study of Risk Factors and Relative Risk

Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Sandel, Elizabeth

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Stroke, Seizures and VTE in Alzheimer's Disease: Incidence and Prevalence in Patients of Kaiser Permanente Northern California

Funder: Janssen AI R&D
Principal Investigator: Whitmer, Rachel

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Multi-ethnic Genome-wide Association Study of Bipolar Disorder

This study aims to identify novel genetic variants that are associated with the risk of bipolar disorder.
Funder: National Institute of Mental Health
Principal Investigator: Schaefer, Catherine

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Impact of Prior Approval for Antidepressants in Medicaid

This study uses longitudinal data methods to evaluate the impact of a prior authorization policy for antidepressants on medication use and health outcomes among new and existing users of antidepressants in Michigan Medicaid.  
Funder: National Institute of Mental Health
Principal Investigator: Adams, Alyce

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Prenatal Factors and Risk of Bipolar Disorder

This project aims to examine potential prenatal exposures in relation to the occurrence of Bipolar I Disorder in a large cohort of adults whose pregnant mothers participated in a study of pregnancy outcomes between 1959 and 1967.
Funder: National Institute of Mental Health
Principal Investigator: Schaefer, Catherine

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Prenatal Determinants of Schizophrenia II

This study investigates the role of prenatal determinants of schizophrenia and schizophrenia spectrum disorder (SSD) by following up a cohort of 19,000 individuals born between 1959 and 1967 in Alameda County, CA.
Funder: National Institute of Mental Health
Principal Investigator: Schaefer, Catherine

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Antipsychotic Medication Use Among Children and Risk of Diabetes Mellitus

Andrade, S. E.; Lo, J. C.; Roblin, D.; Fouayzi, H.; Connor, D. F.; Penfold, R. B.; Chandra, M.; Reed, G.; Gurwitz, J. H.;
Pediatrics  
Nov 21 2011
PubMed abstract  »

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Mental illness and warfarin use in atrial fibrillation

Walker, G. A.; Heidenreich, P. A.; Phibbs, C. S.; Go, A. S.; Chiu, V. Y.; Schmitt, S. K.; Ananth, L.; Frayne, S. M.;
  17 (9): 617-24
Sep 2011
PubMed abstract  »

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Mental illness and warfarin use in atrial fibrillation

Walker, G. A.; Heidenreich, P. A.; Phibbs, C. S.; Go, A. S.; Chiu, V. Y.; Schmitt, S. K.; Ananth, L.; Frayne, S. M.;
The American journal of managed care  17 (9): 617-24
Sep 2011
PubMed abstract  »

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Patterns of alcohol and drug use among depressed older adults seeking outpatient psychiatric services

Satre, D. D.; Sterling, S. A.; Mackin, R. S.; Weisner, C.;
Am J Geriatr Psychiatry   19 (8): 695-703
Aug 2011
PubMed abstract  »

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Does Gender Moderate the Relationship Between Childhood Maltreatment and Adult Depression?

Arnow, B. A.; Blasey, C. M.; Hunkeler, E. M.; Lee, J.; Hayward, C.;
Child Maltreat  
Jul 4 2011
PubMed abstract  »

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Racial and ethnic disparities in postpartum depression care among low-income women

Kozhimannil, K. B.; Trinacty, C. M.; Busch, A. B.; Huskamp, H. A.; Adams, A. S.;
Psychiatr Serv  62 (6): 619-25
Jun 2011
PubMed abstract  »

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Catastrophizing, depression and pain-related disability

Arnow, B. A.; Blasey, C. M.; Constantino, M. J.; Robinson, R.; Hunkeler, E.; Lee, J.; Fireman, B.; Khaylis, A.; Feiner, L.; Hayward, C.;
Gen Hosp Psychiatry   33 (2): 150-6
Mar-Apr 2011
PubMed abstract  »

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Surgical treatment of morbid obesity among patients with bipolar disorder: a research agenda

Ahmed, A. T.; Blair, T. R.; McIntyre, R. S.;
Adv Ther  
Apr 4 2011
PubMed abstract  »

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Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring

Harper, K. N.; Hibbeln, J. R.; Deckelbaum, R.; Quesenberry, C. P., Jr.; Schaefer, C. A.; Brown, A. S.;
Schizophr Res  
Feb 14 2011
PubMed abstract  »

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New Jersey's Efforts To Improve Postpartum Depression Care Did Not Change Treatment Patterns For Women On Medicaid

Kozhimannil, K. B.; Adams, A. S.; Soumerai, S. B.; Busch, A. B.; Huskamp, H. A.;
Health Aff (Millwood)   30 (2): 293-301
Feb 2011
PubMed abstract  »

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Association between prior authorization for medications and health service use by medicaid patients with bipolar disorder

Lu, C. Y.; Adams, A. S.; Ross-Degnan, D.; Zhang, F.; Zhang, Y.; Salzman, C.; Soumerai, S. B.;
Psychiatr Serv   62 (2): 186-93
Feb 2011
PubMed abstract  »

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Subdiagnostic Alcohol Use by Depressed Men and Women Seeking Outpatient Psychiatric Services: Consumption Patterns and Motivation to Reduce Drinking

Satre, D. D.; Chi, F. W.; Eisendrath, S.; Weisner, C.;
Alcohol Clin Exp Res  
Jan 11 2011
PubMed abstract  »

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Vascular Risk Factors and Cognitive Impairment in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study

Tamura, M. K.; Xie, D.; Yaffe, K.; Cohen, D. L.; Teal, V.; Kasner, S. E.; Messe, S. R.; Sehgal, A. R.; Kusek, J.; Desalvo, K. B.; Cornish-Zirker, D.; Cohan, J.; Seliger, S. L.; Chertow, G. M.; Go, A. S.;
Clin J Am Soc Nephrol   epub
Oct 7 2010
PubMed abstract  »

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Correlates of depression among people with diabetes: The Translating Research Into Action for Diabetes (TRIAD) study

Waitzfelder, B.; Gerzoff, R. B.; Karter, A. J.; Crystal, S.; Bair, M. J.; Ettner, S. L.; Brown, A. F.; Subramanian, U.; Lu, S. E.; Marrero, D.; Herman, W. H.; Selby, J. V.; Dudley, R. A.;
Prim Care Diabetes  
Sep 8 2010
PubMed abstract  »

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Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8

Ellman, L. M.; Deicken, R. F.; Vinogradov, S.; Kremen, W. S.; Poole, J. H.; Kern, D. M.; Tsai, W. Y.; Schaefer, C. A.; Brown, A. S.;
Schizophr Res  
Jun 6 2010
PubMed abstract  »