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Research

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Medical Informatics

The Division of Research began as the Department of Medical Methods Research. Its first director, Morris Collen, MD, is a founding father of Medical Informatics. Working together with Sidney Garfield, MD, in the 1950’s, these two founding physicians of Kaiser Permanente adopted the computer as an essential tool in the delivery and improvement of health care. Our researchers carry on that vision in development and use of the electronic health record and the research data base.  

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The Kaiser Permanente National Research Database

The Kaiser Permanente National Research Database 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Terdiman, Joseph

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Development of Clinical Prediction Rules to Predict Risk of Adverse Outcomes in Dizzy Emergency Department Patients

The primary goal of this study is to utilize electronic medical records to follow a cohort of Kaiser Permanente Northern California patients who present to the emergency department with the chief complaint of dizziness for subsequent adverse cerebrovascular and cardiovascular outcomes. Data on these patients will be developed into a clinical prediction rule to assess the risk of adverse outcomes at the initial emergency department presentation.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen

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Fostering Research Collaboration Between UC Davis CTSC and Northern California Kaiser Permanente

The primary goal of this project is to develop a collaborative trauma registry system between UC Davis Medical Center and Kaiser Permanente South Sacramento. This expanded trauma registry system will be used for joint research in the area of traumatic diseases by UC Davis and Kaiser Permanente researchers.
Funder: National Center for Research Resources
Principal Investigator: Offerman, Stephen

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Meaningful Variation in Performance (MVP)

The MVP project synthesizes the existing literature on the topic of performance management in health care and conducts supportive empirical analyses exploring appropriate levels of measurement using Kaiser Permanente Northern California electronic databases.
Funder: Council of Accountable Physician Practices
Principal Investigator: Selby, Joe

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Comparative Effectiveness and Safety of Second-Line Anti-Hypertensive Agents

This project examines issues related to collection of standardized data suitable for research from electronic medical records of multiple health care systems that are members of the HMO Research Network. One of the pilot projects is a longitudinal study among patients with hypertension, measuring current treatment practices and the comparative effectiveness of various pharmacotherapies. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Feedback of Treatment Intensification Data to Reduce Cardiovascular Disease Risk

This study assesses whether the use of systematic feedback on need for treatment intensification in patients with poor control of CVD risk factors improves risk factor control. Using a cluster-randomized trial design, this project leverages health information technology, including Kaiser Permanente’s electronic health record. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Improving Patient Safety and Quality of Care with a Speech Translation Device

This study evaluates the use of speech translation technology, developed for the U.S. military, by hospital nurses to improve patient safety and quality of care. A computer-based speech translation device, which translates spoken English-to-Spanish and spoken Spanish-to-English is used by English-speaking nurses to help communicate with Spanish-speaking patients on a medical/surgical floor at the Kaiser San Francisco Medical Center.
Funder: National Institutes of Health
Principal Investigator: Terdiman, Joseph

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eCare for Health: Diabetes With and Without Co-Morbid Hypertension

This project develops and beta-tests an interactive, Internet-based disease management and clinical decision support program for patients with diabetes with and without comorbid hypertension.
Funder: The Permanente Medical Group
Principal Investigator: Hunkeler, Enid

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The impact of maternal characteristics on the moderately premature infant: an antenatal maternal transport clinical prediction rule

Dukhovny, D.; Dukhovny, S.; Pursley, D. M.; Escobar, G. J.; McCormick, M. C.; Mao, W. Y.; Zupancic, J. A.;
 
Nov 10 2011
PubMed abstract  »

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Medication Exposure in Pregnancy Risk Evaluation Program

Andrade, S. E.; Davis, R. L.; Cheetham, T. C.; Cooper, W. O.; Li, D. K.; Amini, T.; Beaton, S. J.; Dublin, S.; Hammad, T. A.; Pawloski, P. A.; Raebel, M. A.; Smith, D. H.; Staffa, J. A.; Toh, S.; Dashevsky, I.; Haffenreffer, K.; Lane, K.; Platt, R.; Scott, P. E.;
 
Oct 15 2011
PubMed abstract  »

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Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems

Herrinton, L. J.; Curtis, J. R.; Chen, L.; Liu, L.; Delzell, E.; Lewis, J. D.; Solomon, D. H.; Griffin, M. R.; Ouellet-Hellstom, R.; Beukelman, T.; Grijalva, C. G.; Haynes, K.; Kuriya, B.; Lii, J.; Mitchel, E.; Patkar, N.; Rassen, J.; Winthrop, K. L.; Nourjah, P.; Saag, K. G.;
Pharmacoepidemiology and Drug Safety  
Sep 15 2011
PubMed abstract  »

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Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems

Herrinton, L. J.; Curtis, J. R.; Chen, L.; Liu, L.; Delzell, E.; Lewis, J. D.; Solomon, D. H.; Griffin, M. R.; Ouellet-Hellstom, R.; Beukelman, T.; Grijalva, C. G.; Haynes, K.; Kuriya, B.; Lii, J.; Mitchel, E.; Patkar, N.; Rassen, J.; Winthrop, K. L.; Nourjah, P.; Saag, K. G.;
Pharmacoepidemiology and Drug Safety 
Sep 15 2011
PubMed abstract  »

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Diabetes performance measures: current status and future directions

O'Connor, P. J.; Bodkin, N. L.; Fradkin, J.; Glasgow, R. E.; Greenfield, S.; Gregg, E.; Kerr, E. A.; Pawlson, L. G.; Selby, J. V.; Sutherland, J. E.; Taylor, M. L.; Wysham, C. H.;
Diabetes Care  34 (7): 1651-9
Jul 2011
PubMed abstract  »

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Temporal Trends in Recording of Diabetes on Death Certificates: Results from Translating Research Into Action for Diabetes (TRIAD)

McEwen, L. N.; Karter, A. J.; Curb, J. D.; Marrero, D. G.; Crosson, J. C.; Herman, W. H.;
Diabetes Care  34 (7): 1529-33
Jul 2011
PubMed abstract  »

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Ethical and practical challenges of sharing data from genome-wide association studies: the eMERGE Consortium experience

McGuire, A. L.; Basford, M.; Dressler, L. G.; Fullerton, S. M.; Koenig, B. A.; Li, R.; McCarty, C. A.; Ramos, E.; Smith, M. E.; Somkin, C. P.; Waudby, C.; Wolf, W. A.; Clayton, E. W.;
  21 (7): 1001-7
Jul 2011
PubMed abstract  »

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Advancing the science of patient safety

Shekelle, P. G.; Pronovost, P. J.; Wachter, R. M.; Taylor, S. L.; Dy, S. M.; Foy, R.; Hempel, S.; McDonald, K. M.; Ovretveit, J.; Rubenstein, L. V.; Adams, A. S.; Angood, P. B.; Bates, D. W.; Bickman, L.; Carayon, P.; Donaldson, L.; Duan, N.; Farley, D. O.; Greenhalgh, T.; Haughom, J.; Lake, E. T.; Lilford, R.; Lohr, K. N.; Meyer, G. S.; Miller, M. R.; Neuhauser, D. V.; Ryan, G.; Saint, S.; Shojania, K. G.; Shortell, S. M.; Stevens, D. P.; Walshe, K.;
Ann Intern Med   154 (10): 693-6
May 17 2011
PubMed abstract  »

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Active Surveillance for Adverse Events: The Experience of the Vaccine Safety Datalink Project

Yih, W. K.; Kulldorff, M.; Fireman, B. H.; Shui, I. M.; Lewis, E. M.; Klein, N. P.; Baggs, J.; Weintraub, E. S.; Belongia, E. A.; Naleway, A.; Gee, J.; Platt, R.; Lieu, T. A.;
Pediatrics  127 (Suppl 1): S54-S64
Apr 18 2011
PubMed abstract  »

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The Vaccine Safety Datalink: A Model for Monitoring Immunization Safety

Baggs, J.; Gee, J.; Lewis, E.; Fowler, G.; Benson, P.; Lieu, T.; Naleway, A.; Klein, N. P.; Baxter, R.; Belongia, E.; Glanz, J.; Hambidge, S. J.; Jacobsen, S. J.; Jackson, L.; Nordin, J.; Weintraub, E.;
Pediatrics  127 (Suppl 1): S45-S53
May 2011
PubMed abstract  »

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Derivation and Validation of a Model to Predict Daily Risk of Death in Hospital

Wong, J.; Taljaard, M.; Forster, A. J.; Escobar, G. J.; van Walraven, C.;
Med Care  
Apr 6 2011
PubMed abstract  »

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Timely detection of localized excess influenza activity in Northern California across patient care, prescription, and laboratory data

Greene, S. K.; Kulldorff, M.; Huang, J.; Brand, R. J.; Kleinman, K. P.; Hsu, J.; Platt, R.;
Stat Med  30 (5): 549-59
Feb 28 2011
PubMed abstract  »

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The reliability of diagnostic coding and laboratory data to identify tuberculosis and nontuberculous mycobacterial disease among rheumatoid arthritis patients using anti-tumor necrosis factor therapy

Winthrop, K. L.; Baxter, R.; Liu, L.; McFarland, B.; Austin, D.; Varley, C.; Radcliffe, L.; Suhler, E.; Choi, D.; Herrinton, L. J.;
Pharmacoepidemiol Drug Saf  
Dec 10 2010
PubMed abstract  »

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Interpreting complete blood counts soon after birth in newborns at risk for sepsis

Newman, T. B.; Puopolo, K. M.; Wi, S.; Draper, D.; Escobar, G. J.;
Pediatrics  126 (5): 903-9
Nov 2010
PubMed abstract  »

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AALIM: A Cardiac Clinical Decision Support System Powered By Advanced Multi-modal Analytics

Amir, A.; Beymer, D.; Grace, J.; Greenspan, H.; Gruhl, D.; Hobbs, A.; Pohl, K.; Syeda-Mahmood, T.; Terdiman, J.; Wang, F.;
Stud Health Technol Inform   160 846-850
 2010
PubMed abstract  »