The Population-Based Effectiveness in Asthma and Lung Diseases (PEAL) Network
This project will create a new infrastructure to accelerate comparative effectiveness research in asthma and other lung diseases. We will form the Population-Based Effectiveness in Asthma and Lung Diseases (PEAL) Network by aligning and linking computerized data from five health care systems with diverse structural and demographic characteristics.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Fung, Vicki
Randomized Phase 3 Trial of Gemcitabine, Carboplatin with or without BSI-201 (SAR240550) (a PARP1 inhibitor) in Subjects with Previously Untreated Stage IV Squamous Non-Small-Cell Lung Cancer (NSCLC) Protocol 20090321 (EFC11553)
Funder: BiPar Sciences
Principal Investigator: Fehrenbacher, Louis
An Open-Label Rollover Study to Evaluate the Long-Term
Funder: Vertex Pharmaceuticals, Inc.
Principal Investigator: Shay, Gregory
A Randomized Phase II Study of Imetelstat as Maintenance Therapy after Initial Induction Chemotherapy for Advanced Non-Small Cell Lung Cancer (NSCLC) (Protocol CP14B012)
Funder: Geron Corp.
Principal Investigator: Kolevska, Tatjana
New methods for the electronic identification and verification of ventilator-acquired pneumonia (NVAP project)
Novartis Diagnostics and DOR wish to conduct a study on the identification of intensive care unit (ICU) patients with ventilator-associated pneumonia (VAP) using an integrated inpatient electronic medical record (EMR). In order to conduct this study, Novartis Diagnostics would like to work with Dr. Gabriel J. Escobar of The Permanente Medical Group, Inc.'s Division of Research (DOR) to prepare a formal grant proposal for a research project provisionally titled "Electronic identification of VAP in ICU patients" (henceforth, "VAP and the EMR).
Funder: Novartis
Principal Investigator: Escobar, Gabriel
SPIROMICS: Clinical Centers
The goals of this study are to: 1) identify subpopulations of subjects with COPD who are likely to be similar with respect to molecular mechanism of disease, and 2) identify and validate indices of disease severity and progression, which may be useful as intermediate outcome measures in clinical trials.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Epidemiology of Pneumonia in Kaiser Permanente Northern California Population
This is a study of the epidemiology of pneumonia in Kaiser Permanente Northern California and the development of an electronic algorithm to identify pneumonia in outpatients.
Funder: Wyeth-Lederle
Principal Investigator: Baxter, Roger
The Impact of Secondhand Smoke Exposure on COPD Outcomes
This study evaluates the role of education in the incidence of diabetic complications in a large, well-characterized population within an integrated, managed care setting (Kaiser Permanente).
Funder: Tobacco-Related Disease Research Program
Principal Investigator: Iribarren, Carlos
UCSF Center of Excellence on Secondhand Smoke (aka FLOW-FAMRI)
This study seeks to elucidate the factors that determine the risk of developing disability and poor health outcomes among adults with COPD, controlling for degree of pulmonary function impairment; evaluate the impact of specific functional limitations on the risk of developing disability in daily activities and work among relatively young adults with COPD; and elucidate the impact of disability on future adverse health outcomes.
Funder: Flight Attendants' Medical Research Institute
Principal Investigator: Iribarren, Carlos
Asthma and the Risk of Anaphylaxis
This study aims to define the incidence of anaphylaxis among adults and adolescents with asthma; define whether anaphylaxis is more common in asthma than in a matched control population; and elucidate risk factors for anaphylaxis among adults and adolescents with asthma.
Funder: Genentech
Principal Investigator: Iribarren, Carlos
Better Asthma Outcomes: Lowering Tobacco Smoke Exposure
This project tests the hypothesis that an ETS intervention will be associated with decreased asthma crisis care utilization, lower ETS exposure and improvements in secondary disease outcomes at follow-up when compared with usual medical care.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Quesenberry, Charles
Function, Living, Outcomes and Work in COPD (FLOW)
This study seeks to elucidate the factors that determine the risk of developing disability and poor health outcomes among adults with COPD, controlling for degree of pulmonary function impairment; to evaluate the impact of specific functional limitations on the risk of developing disability in daily activities and work among relatively young adults with COPD;and also to elucidate the impact of disability on future adverse health outcomes.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Biomarkers of Lung Cancer Susceptibility in Minorities
This study focuses on African-Americans who bear a disproportionate burden of lung cancer and Latinos who have very low rates.
Funder: Nat. Inst. of Environmental Health Sciences
Principal Investigator: Quesenberry, Charles
Cystic Fibrosis mutations for p.F508del compound heterozygotes
predict sweat chloride levels and pancreatic sufficiency
Sebro, R.;
Levy, H.;
Schneck, K.;
Dimmock, D.;
Raby, B. A.;
Cannon, C. L.;
Broeckel, U.;
Risch, N. J.;
Clinical genetics
Oct 28 2011
PubMed abstract
»
A case-control study of asphalt and tar exposure and lung cancer in
minorities
McClean, M. D.;
Kelsey, K. T.;
Sison, J. D.;
Quesenberry, C. P., Jr.;
Wrensch, M. R.;
Wiencke, J. K.;
Aug 31 2011
PubMed abstract
»
Risk Factors for Tuberculosis After Highly Active Antiretroviral
Therapy Initiation in the United States and Canada: Implications
for Tuberculosis Screening
Sterling, T. R.;
Lau, B.;
Zhang, J.;
Freeman, A.;
Bosch, R. J.;
Brooks, J. T.;
Deeks, S. G.;
French, A.;
Gange, S.;
Gebo, K. A.;
John Gill, M.;
Horberg, M. A.;
Jacobson, L. P.;
Kirk, G. D.;
Kitahata, M. M.;
Klein, M. B.;
Martin, J. N.;
Rodriguez, B.;
Silverberg, M. J.;
Willig, J. H.;
Eron, J. J.;
Goedert, J. J.;
Hogg, R. S.;
Justice, A. C.;
McKaig, R. G.;
Napravnik, S.;
Thorne, J.;
Moore, R. D.;
J Infect Dis
204
(6):
893-901
Sep 2011
PubMed abstract
»
Lung Cancer Survival With Herbal Medicine and Vitamins in a
Whole-Systems Approach: Ten-Year Follow-up Data Analyzed With
Marginal Structural Models and Propensity Score Methods
McCulloch, M.;
Broffman, M.;
van der Laan, M.;
Hubbard, A.;
Kushi, L.;
Kramer, A.;
Gao, J.;
Colford, J. M., Jr.;
Integr Cancer Ther
Aug 8 2011
PubMed abstract
»
Ethnicity and risk of hospitalization for asthma and chronic obstructive pulmonary disease
Tran, H. N.;
Siu, S.;
Iribarren, C.;
Udaltsova, N.;
Klatsky, A. L.;
Annals of Epidemiology
21
(8):
615-22
Aug 2011
PubMed abstract
»
Respiratory and Skeletal Muscle Strength in Chronic Obstructive
Pulmonary Disease
Singer, J.;
Yelin, E. H.;
Katz, P. P.;
Sanchez, G.;
Iribarren, C.;
Eisner, M. D.;
Blanc, P. D.;
J Cardiopulm Rehabil Prev
Jan 13 2011
PubMed abstract
»
Development of disability in chronic obstructive pulmonary disease: beyond lung function
Eisner, M. D.;
Iribarren, C.;
Blanc, P. D.;
Yelin, E. H.;
Ackerson, L.;
Byl, N.;
Omachi, T. A.;
Sidney, S.;
Katz, P. P.;
Thorax
66
(2):
108-14
Feb 2011
PubMed abstract
»
Recurrent wheezing in the third year of life among children born at
32 weeks' gestation or later
Escobar, G. J.;
Ragins, A.;
Li, S. X.;
Prager, L.;
Masaquel, A. S.;
Kipnis, P.;
Arch Pediatr Adolesc Med
164
(10):
915-22
Oct 2010
PubMed abstract
»
COPD and cognitive impairment: the role of hypoxemia and oxygen
therapy
Thakur, N.;
Blanc, P. D.;
Julian, L. J.;
Yelin, E. H.;
Katz, P. P.;
Sidney, S.;
Iribarren, C.;
Eisner, M. D.;
Int J Chron Obstruct Pulmon Dis
5
263-269
2010
PubMed abstract
»
Fine Mapping of Chromosome 15q25.1 Lung Cancer Susceptibility in
African Americans
Hansen, H. M.;
Xiao, Y.;
Rice, T.;
Bracci, P. M.;
Wrensch, M. R.;
Sison, J. D.;
Chang, J. S.;
Smirnov, I. V.;
Patoka, J.;
Seldin, M. F.;
Quesenberry, C. P.;
Kelsey, K. T.;
Wiencke, J. K.;
Hum Mol Genet
Jun 29 2010
PubMed abstract
»
Measurement of COPD severity using a survey-based score: validation
in a clinically and physiologically characterized cohort
Eisner, M. D.;
Omachi, T. A.;
Katz, P. P.;
Yelin, E. H.;
Iribarren, C.;
Blanc, P. D.;
Chest
Dec 29 2009
PubMed abstract
»
Socioeconomic status, race, and COPD health outcomes
Eisner, M. D.;
Blanc, P. D.;
Omachi, T. A.;
Yelin, E. H.;
Sidney, S.;
Katz, P. P.;
Ackerson, L. M.;
Sanchez, G.;
Tolstykh, I.;
Iribarren, C.;
J Epidemiol Community Health
Oct 23 2009
PubMed abstract
»
Patients diagnosed with diabetes are at increased risk for asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and pneumonia but not lung cancer
Ehrlich, S. F.;
Quesenberry, C. P., Jr.;
Van Den Eeden, S. K.;
Shan, J.;
Ferrara, A.;
Diabetes Care
33
(1):
55-60
Jan 2010
PubMed abstract
»
Depression and health-related quality of life in chronic
obstructive pulmonary disease
Omachi, T. A.;
Katz, P. P.;
Yelin, E. H.;
Gregorich, S. E.;
Iribarren, C.;
Blanc, P. D.;
Eisner, M. D.;
Am J Med
122
(8):
778 e9-15
Aug 2009
PubMed abstract
»
The impact of SHS exposure on health status and exacerbations among
patients with COPD
Eisner, M. D.;
Iribarren, C.;
Yelin, E. H.;
Sidney, S.;
Katz, P. P.;
Sanchez, G.;
Blanc, P. D.;
Int J Chron Obstruct Pulmon Dis
4
(1):
169-76
2009
PubMed abstract
»