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Research

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Kidney Diseases

Our researchers examine the links between kidney diseases and other conditions and diseases, particularly cardiovascular (hypertension and heart attacks) and cerebrovascular (stroke). The kidney is also a focus of pharmacoepidemiological studies.

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Retinopathy in Chronic Renal Insufficiency

This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study proposes to do follow-up digital retinal photographs to assess the incidence and progression of retinal abnormalities and their association with cardiovascular disease and progression of chronic kidney disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Prospective Evaluation of Acute Kidney Injury (PEAK) Cohort

Prospective Evaluation of Acute Kidney Injury (PEAK) Cohort 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan

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Chronic Renal Insufficiency Cohort Study II

Chronic Renal Insufficiency Cohort Study II 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan

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Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI)

Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) 
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Alcohol Consumption and Kidney Function

This study investigates the relationship between alcohol consumption and renal function by means of cross-sectional and longitudinal analyses among two large multiphasic examinee cohorts. 
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Klatsky, Arthur

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Chronic Renal Insufficiency Cohort 2 (CRIC 2)

This project establishes a cohort of participants from the CRIC 1 study with chronic kidney disease to have long term prospective follow-up on progression of kidney disease and a variety of different outcomes.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Hispanic Chronic Renal Insufficiency Cohort

This study is recruiting additional Hispanic participants with chronic kidney disease into the Chronic Renal Insufficiency Cohort (CRIC) Study to examine whether the rates of loss of kidney function and subclinical and clinical cardiovascular disease varies among Hispanics versus other race/ethnic groups, after accounting for traditional risk factors.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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CRIC Plus: Study of Advanced Chronic Renal Insufficiency

This study aims to examine how clinical characteristics and morbidity in patients with advanced chronic kidney disease influence the risk of adverse clinical outcomes after the onset of end-stage renal disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Genetics of Atherosclerosis in Renal Disease

This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) study obtains additional electron-beam tomography exams for the measurement of coronary artery calcification at four different clinical centers in the CRIC study.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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MAVERICK

This study leverages previous work to establish a larger, more contemporary, and well-characterized cohort of persons with chronic kidney disease (CKD) to examine the relevant issues in the epidemiology, management, and outcomes in this growing population.
Funder: Amgen
Principal Investigator: Go, Alan

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Cognitive Decline in Chronic Renal Insufficiency

This ancillary study to the prospective Chronic Renal Insufficiency Cohort (CRIC) Study examines the association between severity of kidney dysfunction and risk of cognitive decline, whether it varies by demographic characteristics and diabetes status, and potential mediating pathways including dietary protein intake and subclinical and clinical cardiovascular disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Pulse Wave Velocity in Chronic Kidney Disease

This study seeks to describe the spectrum of pulse wave velocity (PWV) values, a measure of aortic stiffness, in a large cohort of adults with mild-to-moderate chronic kidney disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Linking Acute, Chronic and End-Stage Renal Disease

This study examines the natural history of chronic kidney disease, its association with the risk of acute renal failure, and the impact of acute renal failure on the future short and long-term risk of end-stage renal disease among ~2,000,000 adult members within Kaiser Permanente Northern California with known renal function between 1996-2005.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Heart Failure Incidence and Progression in Renal Disease

This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study describes the epidemiology of chronic heart failure prevalence and incidence among 3,000 adults with mild-to-moderate chronic kidney disease and examines how the severity of kidney dysfunction affects the prognosis and disease-specific quality of life in patients with kidney disease and chronic heart failure.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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Study of the Care and Outcomes of Chronic Renal Insufficiency Cohort (CRIC)

This project establishes a joint San Francisco Bay Area Clinical Center between Kaiser Permanente Northern California and the University of California San Francisco to contribute to the NIDDK-sponsored cohort of 3,000 patients with mild-to-moderate chronic renal insufficiency. 
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan

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FGF23 induces left ventricular hypertrophy

Faul, C.; Amaral, A. P.; Oskouei, B.; Hu, M. C.; Sloan, A.; Isakova, T.; Gutierrez, O. M.; Aguillon-Prada, R.; Lincoln, J.; Hare, J. M.; Mundel, P.; Morales, A.; Scialla, J.; Fischer, M.; Soliman, E. Z.; Chen, J.; Go, A. S.; Rosas, S. E.; Nessel, L.; Townsend, R. R.; Feldman, H. I.; St John Sutton, M.; Ojo, A.; Gadegbeku, C.; Di Marco, G. S.; Reuter, S.; Kentrup, D.; Tiemann, K.; Brand, M.; Hill, J. A.; Moe, O. W.; Kuro, O. M.; Kusek, J. W.; Keane, M. G.; Wolf, M.;
 
Oct 10 2011
PubMed abstract  »

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Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease

Go, A. S.; Bansal, N.; Chandra, M.; Lathon, P. V.; Fortmann, S. P.; Iribarren, C.; Hsu, C. Y.; Hlatky, M. A.;
  58 (15): 1600-7
Oct 4 2011
PubMed abstract  »

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Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease

Go, A. S.; Bansal, N.; Chandra, M.; Lathon, P. V.; Fortmann, S. P.; Iribarren, C.; Hsu, C. Y.; Hlatky, M. A.;
Journal of the American College of Cardiology  58 (15): 1600-7
Oct 4 2011
PubMed abstract  »

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Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study

Bansal, N.; Hsu, C. Y.; Chandra, M.; Iribarren, C.; Fortmann, S. P.; Hlatky, M. A.; Go, A. S.;
  12 (1): 44(9p)
Sep 14 2011
PubMed abstract  »

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Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study

Bansal, N.; Hsu, C. Y.; Chandra, M.; Iribarren, C.; Fortmann, S. P.; Hlatky, M. A.; Go, A. S.;
BMC nephrology  12 (1): 44(9p)
Sep 14 2011
PubMed abstract  »

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Cardiovascular Disease Among Hispanics and Non-Hispanics in the Chronic Renal Insufficiency Cohort (CRIC) Study

Ricardo, A. C.; Lash, J. P.; Fischer, M. J.; Lora, C. M.; Budoff, M.; Keane, M. G.; Kusek, J. W.; Martinez, M.; Nessel, L.; Stamos, T.; Ojo, A.; Rahman, M.; Soliman, E. Z.; Yang, W.; Feldman, H. I.; Go, A. S.;
  6 (9): 2121-2131
Sep 2011
PubMed abstract  »

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CKD in Hispanics: Baseline characteristics from the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic-CRIC Studies

Fischer, M. J.; Go, A. S.; Lora, C. M.; Ackerson, L.; Cohan, J.; Kusek, J. W.; Mercado, A.; Ojo, A.; Ricardo, A. C.; Rosen, L. K.; Tao, K.; Xie, D.; Feldman, H. I.; Lash, J. P.;
American journal of kidney diseases : the official journal of the National Kidney Foundation  58 (2): 214-27
Aug 2011
PubMed abstract  »

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CKD in Hispanics: Baseline characteristics from the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic-CRIC Studies

Fischer, M. J.; Go, A. S.; Lora, C. M.; Ackerson, L.; Cohan, J.; Kusek, J. W.; Mercado, A.; Ojo, A.; Ricardo, A. C.; Rosen, L. K.; Tao, K.; Xie, D.; Feldman, H. I.; Lash, J. P.;
  58 (2): 214-27
Aug 2011
PubMed abstract  »

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Metabolic Syndrome, Components, and Cardiovascular Disease Prevalence in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study

Townsend, R. R.; Anderson, A. H.; Chen, J.; Gadebegku, C. A.; Feldman, H. I.; Fink, J. C.; Go, A. S.; Joffe, M.; Nessel, L. A.; Ojo, A.; Rader, D. J.; Reilly, M. P.; Teal, V.; Teff, K.; Wright, J. T.; Xie, D.;
Am J Nephrol   33 (6): 477-484
Apr 27 2011
PubMed abstract  »

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Symptoms Characteristic of Heart Failure Among CKD Patients Without Diagnosed Heart Failure

Shlipak, M. G.; Lash, J. P.; Yang, W.; Teal, V.; Keane, M.; Cappola, T.; Keller, C.; Jamerson, K.; Kusek, J.; Delafontaine, P.; He, J.; Miller, E. R., 3rd; Schreiber, M.; Go, A. S.;
J Card Fail   17 (1): 17-23
Jan 2011
PubMed abstract  »

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Vascular Risk Factors and Cognitive Impairment in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study

Tamura, M. K.; Xie, D.; Yaffe, K.; Cohen, D. L.; Teal, V.; Kasner, S. E.; Messe, S. R.; Sehgal, A. R.; Kusek, J.; Desalvo, K. B.; Cornish-Zirker, D.; Cohan, J.; Seliger, S. L.; Chertow, G. M.; Go, A. S.;
Clin J Am Soc Nephrol   epub
Oct 7 2010
PubMed abstract  »

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The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods

Go, A. S.; Parikh, C. R.; Ikizler, T. A.; Coca, S.; Siew, E. D.; Chinchilli, V. M.; Hsu, C. Y.; Garg, A. X.; Zappitelli, M.; Liu, K. D.; Reeves, W. B.; Ghahramani, N.; Devarajan, P.; Brown-Faulkner, G.; Tan, T. C.; Kimmel, P. L.; Eggers, P.; Stokes, J. B.; Kidney Injury Assess-Aki Study Investigators, A. S.;
BMC Nephrol   11 (1): 22
Aug 27 2010
PubMed abstract  »

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Central Pulse Pressure in Chronic Kidney Disease. A Chronic Renal Insufficiency Cohort Ancillary Study

Townsend, R. R.; Chirinos, J. A.; Parsa, A.; Weir, M. A.; Sozio, S. M.; Lash, J. P.; Chen, J.; Steigerwalt, S. P.; Go, A. S.; Hsu, C. Y.; Rafey, M.; Wright, J. T., Jr.; Duckworth, M. J.; Gadegbeku, C. A.; Joffe, M. P.;
Hypertension  
Jul 26 2010
PubMed abstract  »

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Chronic kidney disease and prevalent atrial fibrillation: The Chronic Renal Insufficiency Cohort (CRIC)

Soliman, E. Z.; Prineas, R. J.; Go, A. S.; Xie, D.; Lash, J. P.; Rahman, M.; Ojo, A.; Teal, V. L.; Jensvold, N. G.; Robinson, N. L.; Dries, D. L.; Bazzano, L.; Mohler, E. R.; Wright, J. T.; Feldman, H. I.;
Am Heart J   159 (6): 1102-1107
Jun 2010
PubMed abstract  »

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Chronic Kidney Disease and Cognitive Function in Older Adults: Findings from the Chronic Renal Insufficiency Cohort Cognitive Study

Yaffe, K.; Ackerson, L.; Tamura, M. K.; Le Blanc, P.; Kusek, J. W.; Sehgal, A. R.; Cohen, D.; Anderson, C.; Appel, L.; Desalvo, K.; Ojo, A.; Seliger, S.; Robinson, N.; Makos, G.; Go, A. S.;
J Am Geriatr Soc   58 (2): 338-345
Feb 1 2010
PubMed abstract  »