Characteristics of chronic hepatitis B patients in a managed care setting
Describe the virologic measurements, immunologic status (HBV related), liver disease conditions, demographics and treatment histories of a current cohort of adult members with chronic hepatitis B. In a subset of patients receiving antiviral therapy for 2 years or more, assess liver disease markers, comorbidities and severe outcomes.
Funder: Gilead, Inc.
Principal Investigator: Manos, Michele
A Phase 2b Study of BMS-790052 in Combination with Peg-Interferon Alfa-2a and Ribavirin in Treatment Naïve Subjects Company with Chronic Hepatitis C Genotype 1 and 4 Infection. AI444010
Funder: Bristol-Myers Squibb
Principal Investigator: Fessel, Jeffrey
Life After Sepsis Therapy (LAST): A CREST Network, 1 Year Follow-up Study of Early Goal Directed Therapy
This is an observational study of a cohort of subjects who were diagnosed with sepsis in the Emergency Departments of Kaiser Permanente Northern California, looking at the outcomes for a one year period.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Chettipally, Uli
Trends in Methicillin Resistant Staphylococcus Aureus of the Eye and Orbit
This retrospective observational study is looking at the trends in Methicillin Resistant Staphylococcus Aureus (MRSA) of the eye and orbit in patients within Kaiser Permanente Northern California for the years 2002 to 2009; the aim is to improve clinician awareness of common, ayptical, and sight threatening eye infections, proper treatment regimens for endemic areas, and to control emergence of resistant organisms.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Amato, Malena
Hepatitis C Cooperative Research Centers (U19)
The project will address the immunological and immunogenetic correlates of response to antiviral therapy for HCV. Two distinct but complimentary laboratory projects will study the innate and adaptive responses in blood samples from both a retrospective cohort of patients previously treated, and a prospecitve cohort of patients during the first 12 weeks of therapy.
Funder: Nat. Inst. of Allergy and Infectious Diseases
Principal Investigator: Manos, Michele
Influenza Surveillance Data Enhancement Project
Funder: California Dept. of Public Health
Principal Investigator: Baxter, Roger
Rapid Clinical Snapshots From the EMR Among Pneumonia Patients
This project aims to use the inpatient electronic medical record to identify which hospitalized pneumonia patients are at risk for getting worse, and to develop ways to present this information to physicians and nurses so as to prevent the need for admission to intensive care.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Escobar, Gabriel
Surveillance for Invasive Pneumococcal Disease (IPD) and Serotype Replacement in the Ten Years Following Introduction of the Pneumococcal Conjugate Vaccine
Title defines the study.
Funder: Wyeth-Lederle
Principal Investigator: Baxter, Roger
The Epidemiology of Staphylococcus Aureus and Skin and Soft-Tissue Infections in a Managed Care Population
This is a study of the epidemiology of staph infections in Kaiser Permanente Northern California; genotyping of staph strains will be performed in a clinical laboratory and the syndromes attributable to each strain will be determined.
Funder: GlaxoSmithKline
Principal Investigator: Baxter, Roger
Epidemiology of Pneumonia in Kaiser Permanente Northern California Population
This is a study of the epidemiology of pneumonia in Kaiser Permanente Northern California and the development of an electronic algorithm to identify pneumonia in outpatients.
Funder: Wyeth-Lederle
Principal Investigator: Baxter, Roger
An Economic Analysis of Pneumococcal Conjugate Vaccine: An Update
This project revises a previously developed economic model of the pneumococcal conjugate vaccine to incorporate more recent national data on the "herd" effects of the vaccine.
Funder: Wyeth-Lederle
Principal Investigator: Ray, G. Thomas
Incidence and Risk Profiles of Methicillin-resistant Staphylococcus Aureus (MRSA)
The study estimates the annual incidence of MRSA in Kaiser Permanente Northern California HIV-infected patients during the years 1994 to 2006. These estimates will be compared to incidence rates in the general, HIV-negative patient population during the same time period.
Funder: Garfield Memorial Fund
Principal Investigator: DeLorenze, Gerald
Immunogenicity and Safety of a New Meningococcal Conjugate Vaccine Administered to Two to 10 year olds
Funder: Novartis
Principal Investigator: Klein, Nicola
Post-Licensure Safety Surveillance Study of Routine Use of Pentacel
Funder: Sanofi Pasteur
Principal Investigator: Klein, Nicola
Post-licensure Safety Surveillance Study of Routine Use of Meningococcal (Groups A, C, Y, and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra) in Recipients Two to 10 Years of Age
Funder: Sanofi Pasteur
Principal Investigator: Klein, Nicola
Estimating the Probability of Neonatal Early-Onset Infection on the
Basis of Maternal Risk Factors
Puopolo, K. M.;
Draper, D.;
Wi, S.;
Newman, T. B.;
Zupancic, J.;
Lieberman, E.;
Smith, M.;
Escobar, G. J.;
Pediatrics
Oct 24 2011
PubMed abstract
»
H1N1 and Seasonal Influenza Vaccine Safety in the Vaccine Safety
Datalink Project
Lee, G. M.;
Greene, S. K.;
Weintraub, E. S.;
Baggs, J.;
Kulldorff, M.;
Fireman, B. H.;
Baxter, R.;
Jacobsen, S. J.;
Irving, S.;
Daley, M. F.;
Yin, R.;
Naleway, A.;
Nordin, J. D.;
Li, L.;
McCarthy, N.;
Vellozzi, C.;
Destefano, F.;
Lieu, T. A.;
Am J Prev Med
41
(2):
121-8
Aug 2011
PubMed abstract
»
The Pregnancy and Influenza Project: design of an observational case-cohort study to evaluate influenza burden and vaccine effectiveness among pregnant women and their infants
Thompson, M.;
Williams, J.;
Naleway, A.;
Li, D. K.;
Chu, S.;
Bozeman, S.;
Hill, H. A.;
Cragan, J.;
Shay, D. K.;
Am J Obstet Gynecol
204
(6 Suppl 1):
S69-76
Jun 2011
PubMed abstract
»
Healthcare utilization and cost of pneumococcal disease in the
United States
Huang, S. S.;
Johnson, K. M.;
Ray, G. T.;
Wroe, P.;
Lieu, T. A.;
Moore, M. R.;
Zell, E. R.;
Linder, J. A.;
Grijalva, C. G.;
Metlay, J. P.;
Finkelstein, J. A.;
Vaccine
Mar 10 2011
PubMed abstract
»
The reliability of diagnostic coding and laboratory data to
identify tuberculosis and nontuberculous mycobacterial disease
among rheumatoid arthritis patients using anti-tumor necrosis
factor therapy
Winthrop, K. L.;
Baxter, R.;
Liu, L.;
McFarland, B.;
Austin, D.;
Varley, C.;
Radcliffe, L.;
Suhler, E.;
Choi, D.;
Herrinton, L. J.;
Pharmacoepidemiol Drug Saf
Dec 10 2010
PubMed abstract
»
Interpreting complete blood counts soon after birth in newborns at risk for sepsis
Newman, T. B.;
Puopolo, K. M.;
Wi, S.;
Draper, D.;
Escobar, G. J.;
Pediatrics
126
(5):
903-9
Nov 2010
PubMed abstract
»
Recurrent wheezing in the third year of life among children born at
32 weeks' gestation or later
Escobar, G. J.;
Ragins, A.;
Li, S. X.;
Prager, L.;
Masaquel, A. S.;
Kipnis, P.;
Arch Pediatr Adolesc Med
164
(10):
915-22
Oct 2010
PubMed abstract
»
Structural brain alterations in schizophrenia following fetal
exposure to the inflammatory cytokine interleukin-8
Ellman, L. M.;
Deicken, R. F.;
Vinogradov, S.;
Kremen, W. S.;
Poole, J. H.;
Kern, D. M.;
Tsai, W. Y.;
Schaefer, C. A.;
Brown, A. S.;
Schizophr Res
Jun 6 2010
PubMed abstract
»
Surveillance Lessons from First-wave Pandemic (H1N1) 2009, Northern California, USA
Baxter, R.;
Emerg Infect Dis
16
(3):
504-6
Mar 2010
PubMed abstract
»
Otitis media and its consequences: beyond the earache
Vergison, A.;
Dagan, R.;
Arguedas, A.;
Bonhoeffer, J.;
Cohen, R.;
Dhooge, I.;
Hoberman, A.;
Liese, J.;
Marchisio, P.;
Palmu, A. A.;
Ray, G. T.;
Sanders, E. A.;
Simoes, E. A.;
Uhari, M.;
van Eldere, J.;
Pelton, S. I.;
Lancet Infect Dis
10
(3):
195-203
Mar 2010
PubMed abstract
»
Prostatitis, sexually transmitted diseases, and prostate cancer:
the California Men's Health Study
Cheng, I.;
Witte, J. S.;
Jacobsen, S. J.;
Haque, R.;
Quinn, V. P.;
Quesenberry, C. P.;
Caan, B. J.;
Van Den Eeden, S. K.;
PLoS One
5
(1):
e8736
2010
PubMed abstract
»
Immunogenicity and tolerability of a quadrivalent meningococcal
glycoconjugate vaccine in children 2-10 years of age
Black, S.;
Klein, N. P.;
Shah, J.;
Bedell, L.;
Karsten, A.;
Dull, P. M.;
Vaccine
28
(3):
657-63
Jan 8 2010
PubMed abstract
»
Prevalence and predictors of hepatic steatosis in adults with newly
diagnosed chronic liver disease due to hepatitis C
Hayman, A. V.;
Sofair, A. N.;
Manos, M. M.;
Thomas, A.;
Terrault, N.;
Ness, G. V.;
Stabach, N.;
Robert, M.;
Rumore, G.;
Corless, C.;
Bell, B.;
Bialek, S.;
Zaman, A.;
Medicine (Baltimore)
88
(5):
302-6
Sep 2009
PubMed abstract
»
HIV infection and the risk of cancers with and without a known
infectious cause
Silverberg, M. J.;
Chao, C.;
Leyden, W. A.;
Xu, L.;
Tang, B.;
Horberg, M. A.;
Klein, D.;
Quesenberry, C. P., Jr.;
Towner, W. J.;
Abrams, D. I.;
AIDS
Sep 7 2009
PubMed abstract
»
Syphilis epidemiology and clinical outcomes in HIV-infected and HIV-uninfected patients in Kaiser Permanente Northern California
Horberg, M. A.;
Ranatunga, D. K.;
Quesenberry, C. P.;
Klein, D. B.;
Silverberg, M. J.;
Sex Transm Dis
37
(1):
53-8
Jan 2010
PubMed abstract
»