HIV Infection, Immunodeficiency and Skin Cancer

The goald is to: 1. To compare the tumor subtype (basal cell carcinoma, squamous cell carcinoma, and melanoma) and location (sun exposed vs. non-sunexposed) between HIV-infected persons and HIV-uninfected persons with skin cancer. 2. To compare the risk of skin cancer between those with and without HIV infection. 3.  To determine the association of immunodeficiency and skin cancer risk. 4. To compare the tumor invasiveness of cancers according to HIV infection status and level of immunodeficiency.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Asgari, Maryam

HIV-1 Quasispecies During Antiretroviral Therapy

Funder: University of California
Principal Investigator: Fessel, Jeffrey

HPV-Related Outcomes in Kaiser Permanente Patients: Trends Following Vaccine Dissemination

This study’s objective is to provide periodic population-based estimates of prespecified HPV-related clinical outcomes following the licensing and dissemination of the HPV vaccine.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Silverberg, Michael

Observational Post-Authorization Study of Patients Treated With Raltegravir

The purpose of this study is to assess the phase IV safety of raltegravir, an integrase inhibitor recently released for use as an HIV antiretroviral medication, in the course of ordinary clinical practice in Kaiser Permanente Northern and Southern California.
Funder: Merck and Co., Inc.
Principal Investigator: Horberg, Michael

Impact of Missed Office Visits on HIV Outcomes and Mortality

This study will investigate if the frequency of missed visits during the first year after new HIV diagnosis predicts HIV-related outcomes after that year, as has been seen in public care settings.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Horberg, Michael

Developing an HIV-Specific Prevention Index Using the Electronic Medical Record

The overarching objective of this study is to assess in HIV-infected patients, the degree of association between successful general clinical care by HIV disease-treating providers (reflected in overall adherence to recommended general prevention and screening guidelines) and higher-quality HIV-specific care and related outcomes.  The study sample includes nearly 4,900 HIV-infected patients in three Kaiser Permanente (KP) regions (Northwest, Northern California, and Southern California) who received their initial HIV infection diagnosis between 1/1/03 and 12/31/07
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Horberg, Michael

Optimizing Multidisciplinary HIV Care Team for Maximal HAART Adherence

Optimizing Multidisciplinary HIV Care Team for Maximal HAART Adherence 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Horberg, Michael

Optimizing Multidisciplinary HIV Care Team for Max

Retrospective cohort study to determine optimized HIV multidisciplinary care team to maximize HAART adherence and other HIV outcomes and minimize urgent care utilization.
Funder: National Institute of Mental Health
Principal Investigator: Horberg, Michael

Gilead Modern Haart

This retrospective cohort study, using data from Kaiser Permanente, determines the predictors of initiating HAART therapy in the modern treatment era and has that changed over time.
Funder: Gilead, Inc.
Principal Investigator: Horberg, Michael

Prognostic Markers for HIV-related Diffuse Large B-Cell Lymphoma

This retrospective cohort study aims to investigate the prognostic significance of several viral and molecular factors for HIV-related diffuse large B-cell lymphoma (DLBCL) to advance clinical care and provide insight for new molecular therapeutic targets for DLBCL. 
Funder: National Cancer Institute
Principal Investigator: Silverberg, Michael

Considerations of Emerging Issues in the Treatment of HIV ("CEITH")

This interregional study investigates the epidemiology of advanced treatment failure among HIV-infected patients, the utilization of a new class of antiretroviral medications, and the impact of low level viremia on HIV-infected patients being treated with antiretorivral therapy.
Funder: Merck and Co., Inc.
Principal Investigator: Horberg, Michael

Human Papaillomavirus Vaccine Impact Monitoring Through Surveillance of Cervical Precancerous Lesions

This retrospective cohort study of all women in Alameda County monitors the impact of the HPV vaccine on cervical cancer precursor lesions. 
Funder: CDC Foundation
Principal Investigator: Silverberg, Michael

North America AIDS Cohorts Collaboration on Research and Disease (NA-ACCORD)

This study's intent is to perform HIV-related analyses that cannot be accomplished with limited power of individual cohorts or could not be reasonably accomplished by clinical trials. These analyses will be achieved by combining collaborative HIV cohort data (including Kaiser Permanente Northern California) to achieve appropriate power and analyses that could simulate randomized trials where appropriate.
Funder: Nat. Inst. of Allergy and Infectious Diseases
Principal Investigator: Horberg, Michael

Patient Portal to Support Treatment Adherence in HIV Patients

This project includes observational studies describing electronic medical record use and the association with adherence in HIV patients. The observational studies will be followed by a randomized clinical trial to develop and field test a health information technology delivered behavioral intervention to increase adherence to antiretroviral treatment among HIV patients. 
Funder: National Institute of Mental Health
Principal Investigator: Silverberg, Michael

Surveillance for Clinical Adverse Events Among HIV-infected Patients Enrolled in Kaiser Permanente

This study establishes a surveillance system to monitor the incidence and risk factors for serious potential adverse events to antiretroviral therapy. 
Funder: Pfizer
Principal Investigator: Silverberg, Michael

HIV Infection, Immunodeficiency, Viral Replication, and the Risk of Cancer

Silverberg, M. J.; Chao, C.; Leyden, W. A.; Xu, L.; Horberg, M. A.; Klein, D.; Towner, W. J.; Dubrow, R.; Quesenberry, C. P., Jr.; Neugebauer, R. S.; Abrams, D. I.;
 
Nov 22 2011
PubMed abstract  »

Association of Increased Upper Trunk and Decreased Leg Fat With 2-h Glucose in Controls and HIV-Infected Persons

Kosmiski, L. A.; Scherzer, R.; Heymsfield, S. B.; Rimland, D.; Simberkoff, M. S.; Sidney, S.; Shlipak, M. G.; Bacchetti, P.; Biggs, M. L.; Grunfeld, C.;
Diabetes Care  
Sep 16 2011
PubMed abstract  »

Association of Increased Upper Trunk and Decreased Leg Fat With 2-h Glucose in Controls and HIV-Infected Persons

Kosmiski, L. A.; Scherzer, R.; Heymsfield, S. B.; Rimland, D.; Simberkoff, M. S.; Sidney, S.; Shlipak, M. G.; Bacchetti, P.; Biggs, M. L.; Grunfeld, C.;
Diabetes Care 
Sep 16 2011
PubMed abstract  »

Risk Factors for Tuberculosis After Highly Active Antiretroviral Therapy Initiation in the United States and Canada: Implications for Tuberculosis Screening

Sterling, T. R.; Lau, B.; Zhang, J.; Freeman, A.; Bosch, R. J.; Brooks, J. T.; Deeks, S. G.; French, A.; Gange, S.; Gebo, K. A.; John Gill, M.; Horberg, M. A.; Jacobson, L. P.; Kirk, G. D.; Kitahata, M. M.; Klein, M. B.; Martin, J. N.; Rodriguez, B.; Silverberg, M. J.; Willig, J. H.; Eron, J. J.; Goedert, J. J.; Hogg, R. S.; Justice, A. C.; McKaig, R. G.; Napravnik, S.; Thorne, J.; Moore, R. D.;
J Infect Dis   204 (6): 893-901
Sep 2011
PubMed abstract  »

Missing Data on the Estimation of the Prevalence of Accumulated Human Immunodeficiency Virus Drug Resistance in Patients Treated With Antiretroviral Drugs in North America

Abraham, A. G.; Lau, B.; Deeks, S.; Moore, R. D.; Zhang, J.; Eron, J.; Harrigan, R.; Gill, M. J.; Kitahata, M.; Klein, M.; Napravnik, S.; Rachlis, A.; Rodriguez, B.; Rourke, S.; Benson, C.; Bosch, R.; Collier, A.; Gebo, K.; Goedert, J.; Hogg, R.; Horberg, M.; Jacobson, L.; Justice, A.; Kirk, G.; Martin, J.; McKaig, R.; Silverberg, M.; Sterling, T.; Thorne, J.; Willig, J.; Gange, S. J.;
Am J Epidemiol  
Aug 3 2011
PubMed abstract  »

Regional fat deposition and cardiovascular risk in HIV infection: the FRAM study

Lake, J. E.; Wohl, D.; Scherzer, R.; Grunfeld, C.; Tien, P. C.; Sidney, S.; Currier, J. S.;
AIDS care   23 (8): 929-38
Aug 2011
PubMed abstract  »

Regional fat deposition and cardiovascular risk in HIV infection: the FRAM study

Lake, J. E.; Wohl, D.; Scherzer, R.; Grunfeld, C.; Tien, P. C.; Sidney, S.; Currier, J. S.;
AIDS care  23 (8): 929-38
Aug 2011
PubMed abstract  »

HMG-CoA Reductase Inhibitors (Statins) Use and Risk of Non-Hodgkin Lymphoma in HIV+ Persons

Chao, C.; Xu, L.; Abrams, D. I.; Towner, W. J.; Horberg, M. A.; Leyden, W. A.; Silverberg, M. J.;
AIDS 
Jun 15 2011
PubMed abstract  »

Prescription Long-term Opioid Use in HIV-infected Patients

Silverberg, M. J.; Ray, G. T.; Saunders, K.; Rutter, C. M.; Campbell, C. I.; Merrill, J. O.; Sullivan, M. D.; J. Banta-Green C; Von Korff, M.; Weisner, C.;
Clin J Pain 
Jun 14 2011
PubMed abstract  »

Asymmetric dimethylarginine and coronary artery calcium scores are increased in patients infected with human immunodeficiency virus

Jang, J. J.; Berkheimer, S. B.; Merchant, M.; Krishnaswami, A.;
Atherosclerosis  
Apr 5 2011
PubMed abstract  »

Sexual Dysfunction, HIV, and AIDS in Men Who Have Sex with Men

Shindel, A. W.; Horberg, M. A.; Smith, J. F.; Breyer, B. N.;
AIDS Patient Care STDS  
Apr 18 2011
PubMed abstract  »

HIV status is an independent risk factor for reporting lower urinary tract symptoms

Breyer, B. N.; Van den Eeden, S. K.; Horberg, M. A.; Eisenberg, M. L.; Deng, D. Y.; Smith, J. F.; Shindel, A. W.;
  185 (5): 1710-5
May 2011
PubMed abstract  »

Clinical implications of the nelfinavir-proton pump inhibitor drug interaction in patients with human immunodeficiency virus

Saberi, P.; Ranatunga, D. K.; Quesenberry, C. P.; Silverberg, M. J.;
Pharmacotherapy   31 (3): 253-61
Mar 2011
PubMed abstract  »

Association of Vitamin D Insufficiency with Carotid Intima-Media Thickness in HIV-Infected Persons

Choi, A. I.; Lo, J. C.; Mulligan, K.; Schnell, A.; Kalapus, S. C.; Li, Y.; Hunt, P. W.; Martin, J. N.; Deeks, S. G.; Hsue, P. Y.;
Clin Infect Dis  
Jan 27 2011
PubMed abstract  »

HIV Quality Performance Measures in a Large Integrated Health Care System

Horberg, M.; Hurley, L.; Towner, W.; Gambatese, R.; Klein, D.; Antoniskis, D.; Weinberg, W.; Kadlecik, P.; Remmers, C.; Dobrinich, R.; Quesenberry, C.; Silverberg, M.; Johnson, M.;
AIDS Patient Care STDS   25 (1): 21-8
Jan 2011
PubMed abstract  »