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Research

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Genetics

This research seeks to identify genetic and environmental factors that affect health and use that knowledge to improve health care for Kaiser Permanente members and the communities we serve.  

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Genes-Environments and Admixture in Latino Asthmatics (GALA-2)

Funder: Sandler Family Foundation
Principal Investigator: Brigino-Buenaventura, Emerita

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The Epilepsy Phenome/Genome Project

The goals of this study are to better understand what causes epilepsy, why some families have several people with epilepsy, and how to better predict which anti-seizure medications (or no medication) will work best for an individual; for more information please visit www.epgp.org.
Funder: Nat. Inst. of Neurological Disorders and Stroke
Principal Investigator: Hayward, Jean

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Comparative Effectiveness in Genomic & Personalized Medicine for Colon Cancer

This project has a major focus on genetic testing in colorectal cancer.
Funder: National Cancer Institute
Principal Investigator: Kushi, Lawrence

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Kaiser Permanente Autoimmune Disease Registry

This study establishes the Kaiser Permanente Autoimmune Disease Registry, containing comprehensive clinical information for a large, diverse population with access to DNA for future genotyping and functional assays.
Funder: Nat. Inst. of Allergy and Infectious Diseases
Principal Investigator: Herrinton, Lisa

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A Resource for Genetic Epidemiology Research in Adult Health and Aging

A Resource for Genetic Epidemiology Research in Adult Health and Aging 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Schaefer, Catherine

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The Kaiser Permanente Research Program on Genes, Environment and Health (RPGEH): Creating a Resource to Expedite Genomic and Gene-Environment Studies

This project further develops the RPGEH, including collection of 100,000 biospecimens, development of measures of environmental exposures, and further development of infrastructure to support collaborative research projects. 
Funder: Robert Wood Johnson Foundation
Principal Investigator: Schaefer, Catherine

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Multi-ethnic Genome-wide Association Study of Bipolar Disorder

This study aims to identify novel genetic variants that are associated with the risk of bipolar disorder.
Funder: National Institute of Mental Health
Principal Investigator: Schaefer, Catherine

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Whole Genome Association for Early Coronary Artery Disease and Related Phenotypes (ADVANCE)

This project aims to examine the genetic predisposition to early-onset coronary artery disease by performing a whole genome association study of about 500 cases and 500 coronary disease-free controls (Stage 1).
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos

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Genetic and Non-genetic Risk Factors in MS

This case-control study investigates potential genetic, enviromental and clinical determinants of the risk of developing multiple sclerosis and examines potential associations between these factors and disease severity/progression in MS. 
Funder: Nat. Inst. of Neurological Disorders and Stroke
Principal Investigator: Schaefer, Catherine

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Center on Applied Genetic and Epidemiologic Research on Aging

This project helped to fund the development of the Research Program on Genes, Environment and Health through support of a mailed survey of adult Kaiser Permanente Northern California members and development of computerized disease registries.
Funder: Ellison Medical Foundation
Principal Investigator: Schaefer, Catherine

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Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women

Schuh-Huerta, S. M.; Johnson, N. A.; Rosen, M. P.; Sternfeld, B.; Cedars, M. I.; Reijo Pera, R. A.;
 
Nov 24 2011
PubMed abstract  »

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Differentiating Population Stratification from Genotyping Error Using Family Data

Sebro, R.; Lange, C.; Laird, N. M.; Rogus, J. J.; Risch, N. J.;
Annals of human genetics  
Nov 23 2011
PubMed abstract  »

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Ethnic differences in the development of albuminuria: the DISTANCE study

Choi, A. I.; Karter, A. J.; Liu, J. Y.; Young, B. A.; Go, A. S.; Schillinger, D.;
  17 (11): 737-745
Nov 2011
PubMed abstract  »

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Cystic Fibrosis mutations for p.F508del compound heterozygotes predict sweat chloride levels and pancreatic sufficiency

Sebro, R.; Levy, H.; Schneck, K.; Dimmock, D.; Raby, B. A.; Cannon, C. L.; Broeckel, U.; Risch, N. J.;
Clinical genetics  
Oct 28 2011
PubMed abstract  »

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Diet and Colorectal Cancer: Analysis of a Candidate Pathway Using SNPS, Haplotypes, and Multi-Gene Assessment

Slattery, M. L.; Lundgreen, A.; Herrick, J. S.; Caan, B. J.; Potter, J. D.; Wolff, R. K.;
 
Oct 14 2011
PubMed abstract  »

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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Ehret, G. B.; Munroe, P. B.; Rice, K. M.; ,,,; Johnson, A. D.; ...; Smith, A. V.; ...; Abecasis, G. R.; Chakravarti, A.; Elliott, P.; van Duijn, C. M.; Newton-Cheh, C.; Levy, D.; Caulfield, M. J.; Johnson, T.; ...; Fortmann, S.; Assimes, T. L.; Quertermous, T.; Go, A.; Iribarren, C.; Absher, D.; Risch, N.; Myers, R.; Sidney, S.; ...;
Nature   478 (7367): 103-9
Oct 6 2011
PubMed abstract  »

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Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity

Hoffmann, T. J.; Zhan, Y.; Kvale, M. N.; Hesselson, S. E.; Gollub, J.; Iribarren, C.; Lu, Y.; Mei, G.; Purdy, M. M.; Quesenberry, C.; Rowell, S.; Shapero, M. H.; Smethurst, D.; Somkin, C. P.; Van den Eeden, S. K.; Walter, L.; Webster, T.; Whitmer, R. A.; Finn, A.; Schaefer, C.; Kwok, P. Y.; Risch, N.;
Genomics 
Aug 28 2011
PubMed abstract  »

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Autonomic and Adrenocortical Reactivity and Buccal Cell Telomere Length in Kindergarten Children

Kroenke, C. H.; Epel, E.; Adler, N.; Bush, N. R.; Obradovic, J.; Lin, J.; Blackburn, E.; Stamperdahl, J. L.; Boyce, W. T.;
 
Aug 26 2011
PubMed abstract  »

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Candidate Genes and Risk for Cerebral Palsy: a Population-Based Study

Wu, Y. W.; Croen, L. A.; Vanderwerf, A.; Gelfand, A. A.; Torres, A. R.;
Pediatr Res  
Aug 18 2011
PubMed abstract  »

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Sawcer, S.; Hellenthal, G.; Pirinen, M.; Spencer, C. C.; ...; Barcellos, L. F.; ...; Bernstein, A.; ...; Schaefer, C. A.; ...; Shen, L.; Simms-Acuna, B.; ...; Donnelly, P.; Compston, A.;
Nature   476 (7359): 214-9
Aug 11 2011
PubMed abstract  »

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Meta-analysis of new genome-wide association studies of colorectal cancer risk

Peters, U.; Hutter, C. M.; Hsu, L.; Schumacher, F. R.; Conti, D. V.; Carlson, C. S.; Edlund, C. K.; Haile, R. W.; Gallinger, S.; Zanke, B. W.; Lemire, M.; Rangrej, J.; Vijayaraghavan, R.; Chan, A. T.; Hazra, A.; Hunter, D. J.; Ma, J.; Fuchs, C. S.; Giovannucci, E. L.; Kraft, P.; Liu, Y.; Chen, L.; Jiao, S.; Makar, K. W.; Taverna, D.; Gruber, S. B.; Rennert, G.; Moreno, V.; Ulrich, C. M.; Woods, M. O.; Green, R. C.; Parfrey, P. S.; Prentice, R. L.; Kooperberg, C.; Jackson, R. D.; Lacroix, A. Z.; Caan, B. J.; Hayes, R. B.; Berndt, S. I.; Chanock, S. J.; Schoen, R. E.; Chang-Claude, J.; Hoffmeister, M.; Brenner, H.; Frank, B.; Bezieau, S.; Kury, S.; Slattery, M. L.; Hopper, J. L.; Jenkins, M. A.; Le Marchand, L.; Lindor, N. M.; Newcomb, P. A.; Seminara, D.; Hudson, T. J.; Duggan, D. J.; Potter, J. D.; Casey, G.;
Hum Genet  
Jul 15 2011
PubMed abstract  »

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Racial and ethnic differences in the prevalence of placenta previa

Kim, L. H.; Caughey, A. B.; Laguardia, J. C.; Escobar, G. J.;
 
Jun 30 2011
PubMed abstract  »

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Racial and ethnic differences in the prevalence of placenta previa

Kim, L. H.; Caughey, A. B.; Laguardia, J. C.; Escobar, G. J.;
Journal of perinatology : official journal of the California Perinatal Association 
Jun 30 2011
PubMed abstract  »

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Racial Variation in Lipoprotein-Associated Phospholipase A2 in Older Adults

Lee, K. K.; Fortmann, S. P.; Varady, A.; Fair, J. M.; Go, A. S.; Quertermous, T.; Hlatky, M. A.; Iribarren, C.;
BMC Cardiovasc Disord   11 (1): 26
Jun 29 2011
PubMed abstract  »

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Ethical and practical challenges of sharing data from genome-wide association studies: the eMERGE Consortium experience

McGuire, A. L.; Basford, M.; Dressler, L. G.; Fullerton, S. M.; Koenig, B. A.; Li, R.; McCarty, C. A.; Ramos, E.; Smith, M. E.; Somkin, C. P.; Waudby, C.; Wolf, W. A.; Clayton, E. W.;
  21 (7): 1001-7
Jul 2011
PubMed abstract  »