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Research

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Digestive System Diseases

Our researchers examine a wide variety of diseases that affect or are affected by the digestive system, including colorectal  cancer, inflammatory bowel disease, liver disease, and obesity. Our research has contributed to national guidelines for colorectal screening.

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Lactation and Incidence of Type 2 Diabetes in CARDIA Women

The goals of our study are to prospectively examine whether longer duration of lactation is associated with development of type 2 DM in women of reproductive age during the 25-year CARDIA study period (1986-2011) and assess changes in risk factors.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Gunderson, Erica

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Outcomes among patients with recurrent Clostridium difficile infection (CDOC project - C Diff OutComes)

This project will examine predictors of and outcomes after recurrent Clostridium difficile infection in adults.
Funder: Merck and Co., Inc.
Principal Investigator: Escobar, Gabriel

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Adipokines and Barrett's Esophagus

Evaluate role of adipokines in the development of Barrett's esophagus and esophageal adenocarcinoma, using the NCI Barrett's Esophagus and Esophageal Adenocarcinoma Consortium.
Funder: National Institutes of Health
Principal Investigator: Corley, Douglas

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Right-Sided Versus Left-Sided Colon Cancers in Kaiser Permanente Northern California Patients From 1997-2008: A Comparison of Stage at Diagnosis and Survival

Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Goetz, Laura

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Feasibility and Potential Impact of Birth Cohort-Based Hepatitis C Screening

The goal of this feasibility study is to estimate the potential public health and medical care impact of recommended changes in CDC guidelines that all "baby boomers" be screened for hepatitis C regardless of risk, and to design a program evaluation in one to three Kaiser Permanente Northern California facilities.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Manos, Michele

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Is a Ten-Year Interval for Cancer Screening by Colorectal Endoscopy Appropriate? An Update From the Colorectal Cancer Prevention Program

Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Levin, Theodore

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Long-Term Morbidity and Mortality for Liver Transplant Recipients: Understanding the Causes of Death and Identifying Modifiable Risk Factors to Improve Survival (formerly "Outcomes of Liver Transplantation")

The goal is to determine the long-term outcomes of liver transplant patients, their causes of death, and potential morbidities (renal failure, diabetes, etc.).
Funder: Univ. of California, San Francisco Project Grant
Principal Investigator: Corley, Douglas

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Prenatal and Early Life Predictors of Pediatric Onset Inflammatory Bowel Disease

The goal of this study is to identify prenatal and early life exposures that predict development of pediatric onset inflammatory bowel disease (IBD); identifying modifiable, early life risk factors is imperative for developing interventions to prevent IBD in susceptible individuals.
Funder: Health Resources and Services Administration
Principal Investigator: Herrinton, Lisa

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A Cross-sectional Study of Hepatitis C Patients in a Managed Care Setting

This descriptive study characterizes the approximately 21,000 hepatitis C patients who were members of the Kaiser Permanente Northern California health plan in December 2008 and were identified by the KP Viral Hepatitis Registry. Demographic, general medical, antiviral treatment, liver disease markers, and liver disease outcomes are being evaluated.
Funder: Merck and Co., Inc.
Principal Investigator: Manos, Michele

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Predictors of Severe Outcomes in Hepatitis B Patients

This project, using electronic data maintained in the Viral Hepatitis Registry for patients with chronic hepatitis B, seeks to determine the rates of mortality (all cause and liver disease) and specific liver disease outcomes (decompensated cirrhosis, hepatoma, transplant).
Funder: Gilead, Inc.
Principal Investigator: Manos, Michele

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Barrett's Esophagus: Risk Factors in Women

This study utilizes pooling of several existing case-control studies of Barrett's esophagus (a condition that is a preneoplastic risk factor for esophageal adenocarcinoma) to evaluate several risk factors for Barrett's esophagus among women and contrast them with men. 
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Corley, Douglas

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The Effects of Diet on Barrett's Esophagus and Gastroesophageal Reflux Disease

This case control study of more than 950 subjects investigates various potential risk factors on the risk of Barrett's esophagus, a precursor to esophageal adenocarcinoma. The rate of this cancer is the fastest growing in Western countries, and identification of risk factors are crucial in preventing the occurrence of this highly lethal malignancy. 
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Kubo, Ai

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Obesity and Cancers of the Esophagus and Stomach

This study evaluates the associations between obesity, body fat distribution, gastroesophageal reflux symptoms, and esophageal adenocarcinoma using the MHC (spell out?) data set. 
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Corley, Douglas

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Case-control Study of Surveillance for Barrett's Esophagus

This case-control study of persons with Barrett's esophagus evaluates associations between surveillance and survival from esophageal adenocarcinoma.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Corley, Douglas

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Practice Variation in Management of Inflammatory Bowel Disease

The study describes the natural history of CD and UC, and whether care is consistent with practice guidelines. It will assess predictors of therapies, visits, and procedures, including predictors at the level of the patient, the disease, the provider, and the clinic.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Herrinton, Lisa

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Untreated peristomal skin complications among long-term colorectal cancer survivors with ostomies

McMullen, C. K.; Wasserman, J.; Altschuler, A.; Grant, M. L.; Hornbrook, M. C.; Liljestrand, P.; Briggs, C.; Krouse, R. S.;
Clinical journal of oncology nursing   15 (6): 644-50
Dec 1 2011
PubMed abstract  »

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Non-Steroidal Anti-Inflammatory Drug Use Reduces Risk for Adenocarcinomas of the Esophagus and Esophagogastric Junction in a Pooled Analysis

Liao, L. M.; Vaughan, T. L.; Corley, D. A.; Cook, M. B.; Casson, A. G.; Kamangar, F.; Abnet, C. C.; Risch, H. A.; Giffen, C.; Freedman, N. D.; Chow, W. H.; Sadeghi, S.; Pandeya, N.; Whiteman, D. C.; Murray, L. J.; Bernstein, L.; Gammon, M. D.; Wu, A. H.;
Gastroenterology  
Nov 18 2011
PubMed abstract  »

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Role of Thiopurine and Anti-TNF Therapy in Lymphoma in Inflammatory Bowel Disease

Herrinton, L. J.; Liu, L.; Weng, X.; Lewis, J. D.; Hutfless, S.; Allison, J. E.;
 
Oct 25 2011
PubMed abstract  »

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The Future of Colon Cancer Screening: What Do We Recommend and Will It Be Too Much, Too Little, or Just Right?

Corley, D. A.;
Gastroenterology  
Oct 21 2011
PubMed abstract  »

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Re: A Case-Control Study of Levothyroxine and the Risk of Colorectal Cancer

Friedman, G. D.; Schwalbe, J. S.; Habel, L. A.;
 
Oct 18 2011
PubMed abstract  »

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Diet and Colorectal Cancer: Analysis of a Candidate Pathway Using SNPS, Haplotypes, and Multi-Gene Assessment

Slattery, M. L.; Lundgreen, A.; Herrick, J. S.; Caan, B. J.; Potter, J. D.; Wolff, R. K.;
 
Oct 14 2011
PubMed abstract  »

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Colon Cancer Survival With Herbal Medicine and Vitamins Combined With Standard Therapy in a Whole-Systems Approach

McCulloch, M.; Broffman, M.; van der Laan, M.; Hubbard, A.; Kushi, L.; Gao, J.; Abrams, D.; Colford, J. M., Jr.;
 
Sep 30 2011
PubMed abstract  »

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Optimizing Colorectal Cancer Screening by Getting FIT Right

Levin, T. R.;
Gastroenterology  
Sep 21 2011
PubMed abstract  »

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Optimizing Colorectal Cancer Screening by Getting FIT Right

Levin, T. R.;
Gastroenterology 
Sep 21 2011
PubMed abstract  »

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Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?

Yuhara, H.; Steinmaus, C.; Cohen, S. E.; Corley, D. A.; Tei, Y.; Buffler, P. A.;
 
Sep 13 2011
PubMed abstract  »

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Diagnosis, Comorbidities And Management Of Irritable Bowel Syndrome In Patients In A Large Health Maintenance Organization

Ladabaum, U.; Boyd, E.; Zhao, W. K.; Mannalithara, A.; Sharabidze, A.; Singh, G.; Chung, E.; Levin, T. R.;
 
Aug 23 2011
PubMed abstract  »

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The FLU-FIT program: an effective colorectal cancer screening program for high volume flu shot clinics

Potter, M. B.; Somkin, C. P.; Ackerson, L. M.; Gomez, V.; Dao, T.; Horberg, M. A.; Walsh, J. Me;
Am J Manag Care   17 (8): 577-83
 2011
PubMed abstract  »

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Meta-analysis of new genome-wide association studies of colorectal cancer risk

Peters, U.; Hutter, C. M.; Hsu, L.; Schumacher, F. R.; Conti, D. V.; Carlson, C. S.; Edlund, C. K.; Haile, R. W.; Gallinger, S.; Zanke, B. W.; Lemire, M.; Rangrej, J.; Vijayaraghavan, R.; Chan, A. T.; Hazra, A.; Hunter, D. J.; Ma, J.; Fuchs, C. S.; Giovannucci, E. L.; Kraft, P.; Liu, Y.; Chen, L.; Jiao, S.; Makar, K. W.; Taverna, D.; Gruber, S. B.; Rennert, G.; Moreno, V.; Ulrich, C. M.; Woods, M. O.; Green, R. C.; Parfrey, P. S.; Prentice, R. L.; Kooperberg, C.; Jackson, R. D.; Lacroix, A. Z.; Caan, B. J.; Hayes, R. B.; Berndt, S. I.; Chanock, S. J.; Schoen, R. E.; Chang-Claude, J.; Hoffmeister, M.; Brenner, H.; Frank, B.; Bezieau, S.; Kury, S.; Slattery, M. L.; Hopper, J. L.; Jenkins, M. A.; Le Marchand, L.; Lindor, N. M.; Newcomb, P. A.; Seminara, D.; Hudson, T. J.; Duggan, D. J.; Potter, J. D.; Casey, G.;
Hum Genet  
Jul 15 2011
PubMed abstract  »

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Can we improve adenoma detection rates? A systematic review of intervention studies

Corley, D. A.; Jensen, C. D.; Marks, A. R.;
Gastrointest Endosc  
Jul 7 2011
PubMed abstract  »

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Organized Colorectal Cancer Screening in Integrated Health Care Systems

Levin, T. R.; Jamieson, L.; Burley, D. A.; Reyes, J.; Oehrli, M.; Caldwell, C.;
Epidemiol Rev 
Jun 27 2011
PubMed abstract  »