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Research

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Dementia

According to the National Institutes of Health, dementia is an acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. Our researchers are seeking to better understand the risk and protective factors related to dementia, particularly in aging populations.

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Dementia After Traumatic Brain Injury: A Longitudinal Study of Risk Factors and Relative Risk

Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Sandel, Elizabeth

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Sex Hormones, Related Polymorphisms and Cognitive Decline

This study seeks to ascertain the role of hormone replacement therapy in midlife on risk of dementia.
Funder: National Institute on Aging
Principal Investigator: Whitmer, Rachel

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Midlife Respiratory Function and Risk of Dementia

 This study evaluates the association between midlife respiratory function and risk of dementia more than two decades later. A secondary aim is to ascertain how the association between respiratory function and dementia risk may vary by smoking status.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Whitmer, Rachel

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Timing of hormone therapy and dementia: the critical window theory revisited

Whitmer, R. A.; Quesenberry, C. P.; Zhou, J.; Yaffe, K.;
Ann Neurol   69 (1): 163-9
Jan 2011
PubMed abstract  »

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Timing of hormone therapy and dementia: The critical window theory revisited

Whitmer, R. A.; Quesenberry, C. P.; Zhou, J.; Yaffe, K.;
Ann Neurol  69 (1): 163-9
Jan 2011
PubMed abstract  »

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Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia

Rusanen, M.; Kivipelto, M.; Quesenberry, C. P., Jr.; Zhou, J.; Whitmer, R. A.;
Arch Intern Med  
Oct 25 2010
PubMed abstract  »

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Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

Li, N. C.; Lee, A.; Whitmer, R. A.; Kivipelto, M.; Lawler, E.; Kazis, L. E.; Wolozin, B.;
BMJ   340 b5465
 2010
PubMed abstract  »

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Midlife Serum Cholesterol and Increased Risk of Alzheimer's and Vascular Dementia Three Decades Later

Solomon, A.; Kivipelto, M.; Wolozin, B.; Zhou, J.; Whitmer, R. A.;
Dement Geriatr Cogn Disord   28 (1): 75-80
Aug 4 2009
PubMed abstract  »

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NSAID exposure and risk of Alzheimer disease: is timing everything?

Bennett, D. A.; Whitmer, R. A.;
Neurology   72 (22): 1884-5
Jun 2 2009
PubMed abstract  »

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Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus

Whitmer, R. A.; Karter, A. J.; Yaffe, K.; Quesenberry, C. P., Jr.; Selby, J. V.;
JAMA   301 (15): 1565-72
Apr 15 2009
PubMed abstract  »

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Central obesity and increased risk of dementia more than three decades later

Whitmer, R. A.; Gustafson, D. R.; Barrett-Connor, E.; Haan, M. N.; Gunderson, E. P.; Yaffe, K.;
Neurology   71 (14): 1057-64
Sep 30 2008
PubMed abstract  »

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Type 2 diabetes and risk of cognitive impairment and dementia

Whitmer, R. A.;
Curr Neurol Neurosci Rep   7 (5): 373-80
Sep 2007
PubMed abstract  »

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Body mass index in midlife and risk of Alzheimer disease and vascular dementia

Whitmer, R. A.; Gunderson, E. P.; Quesenberry, C. P., Jr.; Zhou, J.; Yaffe, K.;
Curr Alzheimer Res   4 (2): 103-9
Apr 2007
PubMed abstract  »

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The epidemiology of adiposity and dementia

Whitmer, R. A.;
Curr Alzheimer Res   4 (2): 117-22
Apr 2007
PubMed abstract  »

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Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging

Haan, M. N.; Miller, J. W.; Aiello, A. E.; Whitmer, R. A.; Jagust, W. J.; Mungas, D. M.; Allen, L. H.; Green, R.;
Am J Clin Nutr   85 (2): 511-7
Feb 2007
PubMed abstract  »

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Physical activity and dementia: The need for prevention trials

Barnes, D. E.; Whitmer, R. A.; Yaffe, K.;
Exerc Sport Sci Rev   35 (1): 24-9
Jan 2007
PubMed abstract  »

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Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women

Yaffe, K.; Blackwell, T.; Whitmer, R. A.; Krueger, K.; Barrett Connor, E.;
J Nutr Health Aging   10 (4): 293-5
Jul-Aug 2006
PubMed abstract  »

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Obesity and dementia: lifecourse evidence and mechanisms

Whitmer, R. A.; Yaffe, K.;
Aging Health   2 (4): 571-578
Aug 2006
PubMed abstract  »