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Research

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Comparative Effectiveness Research

Comparative effectiveness research is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat and monitor a clinical condition, or to improve the delivery of care. The purpose of comparative effectiveness research is to assist consumers, clinicians, purchasers, and policy-makers to make informed decisions that will improve health care at both the individual and population levels.

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Multi-institutional Consortium for CER in Diabetes Treatment and Prevention

To build a standardized diabetes registry (including children and adults) across participating HMORN sites, to be used for comparative effectiveness studies of diabetes prevention and CVD risk reduction.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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The Influence of Glycemic Control on Surgical Complications, Revisions, and Hospital Readmissions Following Total Joint Replacement

To investigate the influence of glycemic control on surgical complications, revisions, hospital readmissions following total joint replacement using the Total Joint Replacement Registry (TJRR) and the CESR Virtual Data Warehouse (VDW).
Funder: Center for Comparative Effectiveness
Principal Investigator: Ferrara, Assiamira

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Comparative Effectiveness in Genomic & Personalized Medicine for Colon Cancer

This project has a major focus on genetic testing in colorectal cancer.
Funder: National Cancer Institute
Principal Investigator: Kushi, Lawrence

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Building CER Capacity: Aligning CRN, CMS, and State Resources to Map Center Care

This is a project to develop capacity to examine patterns of care and outcomes, across data derived from selected CRN sites (KPNC, KPNW, KPCO, KPGA, GHC), SEER-Medicare, Medicaid, and the National Comprehensive Cancer Network.
Funder: National Cancer Institute
Principal Investigator: Kushi, Lawrence

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Effectiveness of Immediate Vs. Delayed Use of Metaformin in New-Onset T2 Diabetes

Effectiveness of Immediate Vs. Delayed Use of Metaformin in New-Onset T2 Diabetes 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Selby, Joe

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Analytic Briefs for Supporting Comparative Effectiveness Research and Systematic Reviews in Diabetes

The overall aim of this study is to evaluate the feasibility of creating nationally representative, diabetes-specific reports and describe their utility to various stakeholders.  
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Diabetes Multicenter Research Consortium

This HMO Research Network project is a task order-driven contract arrangement with the Agency for Healthcare Research and Quality to conduct studies of comparative effectiveness in the treatment of type 2 diabetes. The first funded task order involves a comparison of bariatric surgery with usual medical care in persons with diabetes. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Comparative Effectiveness and Safety of Second-Line Anti-Hypertensive Agents

This project examines issues related to collection of standardized data suitable for research from electronic medical records of multiple health care systems that are members of the HMO Research Network. One of the pilot projects is a longitudinal study among patients with hypertension, measuring current treatment practices and the comparative effectiveness of various pharmacotherapies. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Translating Research into Action for Diabetes (TRIAD II)

The goals of this study are to describe current levels of diabetes care, analyze system-level determinants of level of care, study health care professional and patient-level factors that influence the effectiveness of care, develop new quality indicators, and identify and evaluate interventions that aim to improve levels of screening and risk management for patients with diabetes. 
Funder: Centers for Disease Control and Prevention
Principal Investigator: Selby, Joe

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Initiation of Tumor Necrosis Factor-alpha Antagonists and the Risk of Hospitalization for Infection in Patients With Autoimmune Diseases

Grijalva, C. G.; Chen, L.; Delzell, E.; Baddley, J. W.; Beukelman, T.; Winthrop, K. L.; Griffin, M. R.; Herrinton, L. J.; Liu, L.; Ouellet-Hellstrom, R.; Patkar, N. M.; Solomon, D. H.; Lewis, J. D.; Xie, F.; Saag, K. G.; Curtis, J. R.;
 
Nov 6 2011
PubMed abstract  »

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Colon Cancer Survival With Herbal Medicine and Vitamins Combined With Standard Therapy in a Whole-Systems Approach

McCulloch, M.; Broffman, M.; van der Laan, M.; Hubbard, A.; Kushi, L.; Gao, J.; Abrams, D.; Colford, J. M., Jr.;
 
Sep 30 2011
PubMed abstract  »

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Methods for Assessing Fracture Risk Prediction Models: Experience With FRAX in a Large Integrated Health Care Delivery System

Pressman, A. R.; Lo, J. C.; Chandra, M.; Ettinger, B.;
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry  
Sep 28 2011
PubMed abstract  »

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Methods for Assessing Fracture Risk Prediction Models: Experience With FRAX in a Large Integrated Health Care Delivery System

Pressman, A. R.; Lo, J. C.; Chandra, M.; Ettinger, B.;
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 
Sep 28 2011
PubMed abstract  »

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Combination therapy as initial treatment for newly diagnosed hypertension

Byrd, J. B.; Zeng, C.; Tavel, H. M.; Magid, D. J.; O'Connor, P. J.; Margolis, K. L.; Selby, J. V.; Ho, P. M.;
Am Heart J   162 (2): 340-6
Aug 2011
PubMed abstract  »

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Lung Cancer Survival With Herbal Medicine and Vitamins in a Whole-Systems Approach: Ten-Year Follow-up Data Analyzed With Marginal Structural Models and Propensity Score Methods

McCulloch, M.; Broffman, M.; van der Laan, M.; Hubbard, A.; Kushi, L.; Kramer, A.; Gao, J.; Colford, J. M., Jr.;
Integr Cancer Ther  
Aug 8 2011
PubMed abstract  »

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Using medicare data for comparative effectiveness research: opportunities and challenges

Fung, V.; Brand, R. J.; Newhouse, J. P.; Hsu, J.;
Am J Manag Care   17 (7): 488-96
 2011
PubMed abstract  »

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Missing Data on the Estimation of the Prevalence of Accumulated Human Immunodeficiency Virus Drug Resistance in Patients Treated With Antiretroviral Drugs in North America

Abraham, A. G.; Lau, B.; Deeks, S.; Moore, R. D.; Zhang, J.; Eron, J.; Harrigan, R.; Gill, M. J.; Kitahata, M.; Klein, M.; Napravnik, S.; Rachlis, A.; Rodriguez, B.; Rourke, S.; Benson, C.; Bosch, R.; Collier, A.; Gebo, K.; Goedert, J.; Hogg, R.; Horberg, M.; Jacobson, L.; Justice, A.; Kirk, G.; Martin, J.; McKaig, R.; Silverberg, M.; Sterling, T.; Thorne, J.; Willig, J.; Gange, S. J.;
Am J Epidemiol  
Aug 3 2011
PubMed abstract  »

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The Comparative Effectiveness of Mail Order Pharmacy Use vs. Local Pharmacy Use on LDL-C Control in New Statin Users

Schmittdiel, J. A.; Karter, A. J.; Dyer, W.; Parker, M.; Uratsu, C.; Chan, J.; Duru, O. K.;
J Gen Intern Med  
Jul 20 2011
PubMed abstract  »

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A New Risk Scheme to Predict Warfarin-Associated Hemorrhage The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study

Fang, M. C.; Go, A. S.; Chang, Y.; Borowsky, L. H.; Pomernacki, N. K.; Udaltsova, N.; Singer, D. E.;
J Am Coll Cardiol   58 (4): 395-401
Jul 19 2011
PubMed abstract  »

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Randomised trial comparing hand expression with breast pumping for mothers of term newborns feeding poorly

Flaherman, V. J.; Gay, B.; Scott, C.; Avins, A.; Lee, K. A.; Newman, T. B.;
Arch Dis Child Fetal Neonatal Ed  
Jul 11 2011
PubMed abstract  »

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Accounting for the mortality benefit of drug-eluting stents in percutaneous coronary intervention: a comparison of methods in a retrospective cohort study

Yeh, R. W.; Chandra, M.; McCulloch, C. E.; Go, A. S.;
BMC medicine   9 78(9p)
 2011
PubMed abstract  »

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Accounting for the mortality benefit of drug-eluting stents in percutaneous coronary intervention: a comparison of methods in a retrospective cohort study

Yeh, R. W.; Chandra, M.; McCulloch, C. E.; Go, A. S.;
BMC medicine  978(9p)
 2011
PubMed abstract  »

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The impact of the iPLEDGE program on isotretinoin fetal exposure in an integrated health care system

Shin, J.; Cheetham, T. C.; Wong, L.; Niu, F.; Kass, E.; Yoshinaga, M. A.; Sorel, M.; McCombs, J. S.; Sidney, S.;
J Am Acad Dermatol  
May 10 2011
PubMed abstract  »

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Interdisciplinary treatment for vestibular dysfunction: the effectiveness of mindfulness, cognitive-behavioral techniques, and vestibular rehabilitation

Naber, C. M.; Water-Schmeder, O.; Bohrer, P. S.; Matonak, K.; Bernstein, A. L.; Merchant, M. A.;
  145 (1): 117-24
Jul 2011
PubMed abstract  »