A Randomized Multicenter Clinical Trial of Unruptured Brain AVMs (ARUBA)

The primary goal is to determine whether medical management improves long-term outcomes of patients with unruptured BAVMs compared to interventional therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in combination). The trial has been designed to test whether medical management or interventional therapy will reduce the risk of death or stroke (due to hemorrhage or infarction) by at least 40% (an absolute magnitude of about 7.5% over 5 years).
Funder: Nat. Inst. of Neurological Disorders and Stroke
Principal Investigator: Cullen, Sean

Epilepsy after Pediatric Stroke: A Population-based Study

This is retrospective cohort study with the overall objective of determining the incidence and predictors of epilepsy after stroke in neonates and children. We will use a previously identified cohort of 492 children with stroke in the KP population (1993-2007). We will identify cases with epilepsy through electronic searches of diagnostic databases, and confirm the epilepsy diagnosis through chart review.
Funder: Univ. of California, San Francisco Project Grant
Principal Investigator: Sidney, Stephen

Phase II of PAC Outcome Monitoring Study

This study focuses on the functional outcomes of a cohort of 270 patients hospitalized after a stroke, with measurements of function in mobility, self-care and applied cognition at discharge from various levels of care across a 6-month period.
Funder: National Institutes of Health
Principal Investigator: Sandel, Elizabeth

Prevalence of Immediate and Delayed Intra-Cranial Hemorrhage After Head Trauma Associated With Pre-Injury Anti-Coagulant Use

Funder: Garfield Memorial Fund
Principal Investigator: Offerman, Stephen

Effect of Race-ethnicity on Anti-Hypertensive Therapy and Blood Pressure Control in Patients with Ischemic Stroke

The specific aims of this study are to: 1) determine in the QUISP cohort the factors that could explain why African Americans have poorer blood pressure control compared to other races by examining potential barriers among patients with acute ischemic stroke in a large racially-diverse cohort, and 2) to determine to what extent failure to control blood pressure could account for the difference in 6 month post-stroke risk in recurrent stroke among the different races.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen

Kaiser Permanente Functional Outcomes System

Kaiser Permanente Functional Outcomes System 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Sandel, Elizabeth

Development of Clinical Prediction Rules to Predict Risk of Adverse Outcomes in Dizzy Emergency Department Patients

The primary goal of this study is to utilize electronic medical records to follow a cohort of Kaiser Permanente Northern California patients who present to the emergency department with the chief complaint of dizziness for subsequent adverse cerebrovascular and cardiovascular outcomes. Data on these patients will be developed into a clinical prediction rule to assess the risk of adverse outcomes at the initial emergency department presentation.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen

Medications for ADHD and Risk of Serious Cardiovascular Disease in Adults: Addition of Stroke Endpoint

This study examines the risk of stroke associated with medications used to treat ADHD.
Funder: Food and Drug Administration
Principal Investigator: Habel, Laurel

The Burden of Childhood Stroke: Financial Costs and Health-related Quality of Life

This study measures utility scores for childhood/neonatal stroke from "societal" and from "patient" perspectives by interviewing parents of "at risk" children and parents of children that have suffered stroke.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen

Is Stroke a Late Effect of Chemotherapy?

This study will use the patient and Virtual Data Warehouse resources of the Cancer Research Network to estimate incidence of stroke by treatment modality among patients diagnosed from 1994 to 2003 with bladder, female breast, colorectal, Hodgkin's lymphoma, adult leukemia multiple myeloma, non-Hodgkin's lymphoma, ovarian and testicular cancers.
Funder: National Institute of Aging
Principal Investigator: Herrinton, Lisa

The Role of Infection in Childhood Stroke

This study determines whether infection is a risk factor for childhood stroke, including both first stroke and stroke recurrence, based on medical record review and structured interview of stroke cases (or surrogates) and age-matched controls randomly selected. 
Funder: Nat. Inst. of Neurological Disorders and Stroke
Principal Investigator: Sidney, Stephen

Does primary stroke center certification change ED diagnosis, utilization, and disposition of patients with acute stroke?

Ballard, D. W.; Reed, M. E.; Huang, J.; Kramer, B. J.; Hsu, J.; Chettipally, U.;
 
Nov 17 2011
PubMed abstract  »

Statin Use During Ischemic Stroke Hospitalization Is Strongly Associated With Improved Poststroke Survival

Flint, A. C.; Kamel, H.; Navi, B. B.; Rao, V. A.; Faigeles, B. S.; Conell, C.; Klingman, J. G.; Sidney, S.; Hills, N. K.; Sorel, M.; Cullen, S. P.; Johnston, S. C.;
 
Oct 20 2011
PubMed abstract  »

Validation of the Stroke Prognostic Instrument-II in a Large, Modern, Community-Based Cohort of Ischemic Stroke Survivors

Navi, B. B.; Kamel, H.; Sidney, S.; Klingman, J. G.; Nguyen-Huynh, M. N.; Johnston, S. C.;
 
Sep 29 2011
PubMed abstract  »

Validation of the Stroke Prognostic Instrument-II in a Large, Modern, Community-Based Cohort of Ischemic Stroke Survivors

Navi, B. B.; Kamel, H.; Sidney, S.; Klingman, J. G.; Nguyen-Huynh, M. N.; Johnston, S. C.;
Stroke; a journal of cerebral circulation  
Sep 29 2011
PubMed abstract  »

Postacute care and ischemic stroke mortality: findings from an integrated health care system in northern california

Wang, H.; Sandel, M. E.; Terdiman, J.; Armstrong, M. A.; Klatsky, A.; Camicia, M.; Sidney, S.;
  3 (8): 686-94
Aug 2011
PubMed abstract  »

Cardiovascular Predictors of Long-Term Outcomes After Non-Traumatic Subarachnoid Hemorrhage

Zaroff, J. G.; Leong, J.; Kim, H.; Young, W. L.; Cullen, S. P.; Rao, V. A.; Sorel, M.; Quesenberry, C. P., Jr.; Sidney, S.;
Neurocrit Care  
Jul 19 2011
PubMed abstract  »

Practice variation in neuroimaging to evaluate dizziness in the ED

Kim, A. S.; Sidney, S.; Klingman, J. G.; Johnston, S. C.;
Am J Emerg Med  
May 11 2011
PubMed abstract  »

Detection of Atrial Fibrillation After Stroke and the Risk of Recurrent Stroke

Kamel, H.; Johnson, D. R.; Hegde, M.; Go, A. S.; Sidney, S.; Sorel, M.; Hills, N. K.; Johnston, S. C.;
J Stroke Cerebrovasc Dis  
May 3 2011
PubMed abstract  »

Time to inpatient rehabilitation hospital admission and functional outcomes of stroke patients

Wang, H.; Camicia, M.; Terdiman, J.; Hung, Y. Y.; Sandel, M. E.;
PM R   3 (4): 296-304
Apr 2011
PubMed abstract  »

Elevated BNP is Associated with Vasospasm-Independent Cerebral Infarction Following Aneurysmal Subarachnoid Hemorrhage

Taub, P. R.; Fields, J. D.; Wu, A. H.; Miss, J. C.; Lawton, M. T.; Smith, W. S.; Young, W. L.; Zaroff, J. G.; Ko, N. U.;
Neurocrit Care  
Apr 9 2011
PubMed abstract  »

Angiopoietin-Like 4 (ANGPTL4) Gene Polymorphisms and Risk of Brain Arteriovenous Malformations

Mikhak, B.; Weinsheimer, S.; Pawlikowska, L.; Poon, A.; Kwok, P. Y.; Lawton, M. T.; Chen, Y.; Zaroff, J. G.; Sidney, S.; McCulloch, C. E.; Young, W. L.; Kim, H.;
Cerebrovasc Dis   31 (4): 338-345
Jan 7 2011
PubMed abstract  »

Heart Disease and Stroke Statistics--2011 Update: A Report From the American Heart Association

Roger, V. L.; Go, A. S.; Lloyd-Jones, D. M.; Adams, R. J.; Berry, J. D.; Brown, T. M.; Carnethon, M. R.; Dai, S.; de Simone, G.; Ford, E. S.; Fox, C. S.; Fullerton, H. J.; Gillespie, C.; Greenlund, K. J.; Hailpern, S. M.; Heit, J. A.; Ho, P. M.; Howard, V. J.; Kissela, B. M.; Kittner, S. J.; Lackland, D. T.; Lichtman, J. H.; Lisabeth, L. D.; Makuc, D. M.; Marcus, G. M.; Marelli, A.; Matchar, D. B.; McDermott, M. M.; Meigs, J. B.; Moy, C. S.; Mozaffarian, D.; Mussolino, M. E.; Nichol, G.; Paynter, N. P.; Rosamond, W. D.; Sorlie, P. D.; Stafford, R. S.; Turan, T. N.; Turner, M. B.; Wong, N. D.; Wylie-Rosett, J.;
Circulation  123 (4): 459-63
Feb 1 2011
PubMed abstract  »

Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia

Rusanen, M.; Kivipelto, M.; Quesenberry, C. P., Jr.; Zhou, J.; Whitmer, R. A.;
Arch Intern Med  
Oct 25 2010
PubMed abstract  »

Urgent neurology consultation from the ED for transient ischemic attack

Kim, A. S.; Sidney, S.; Bernstein, A. L.; Douglas, V. C.; Johnston, S. C.;
Am J Emerg Med  
Apr 23 2010
PubMed abstract  »

Gender Differences in Treatment of Severe Carotid Stenosis After Transient Ischemic Attack

Poisson, S. N.; Johnston, S. C.; Sidney, S.; Klingman, J. G.; Nguyen-Huynh, M. N.;
Stroke  
Jul 22 2010
PubMed abstract  »