Epidemiology: Oxidative Stress and Early Atherosclerosis
The renewal of this study utilizes and expands the infrastructure of the CARDIA year 25 examination planned for 2010-2011 to obtain additional blood and urine samples and to perform additional biochemical analyses to elucidate early stages in the pathogenesis of CVD and etiologically related conditions.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
Effectiveness of medical therapy, endovascular therapy, and surgery for peripheral arterial disease
The objective is to inform current practice regarding peripheral arterial disease (PAD) treatment as follows: 1) to assemble a registry of PAD patients (n=60,000) in 2 integrated healthcare delivery systems and collect detailed chart abstracted procedural data (n=3,000) for those who undergo endovascular or surgical revascularization; 2) to describe demographics, co-morbidities, medications, and risk factor control of diagnosed PAD patients by medical therapy only, endovascular therapy or surgery; and 3) to assess the comparative effectiveness of surgery versus endovascular therapy for PAD.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Go, Alan
Longitudinal Changes in Pericardial Adiposity and Subclinical Atherosclerosis
The main goal of this CARDIA ancillary is to measure coronary atherosclerosis during the year 25 exam in 2010-11 using 64 channel cardiac CT in at least 90% of the CARDIA study examinees.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
Comparison of Bayesian and frequentist methods in cardiovascular clinical trials
The goal of this proposed research is to study Bayesian clinical trials methods in real-data.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Pressman, Alice
Mental Health Disorders & Medication Adherence & Outcomes in Hypertension, Atrial Fibrillation & Venous Thromboembolism within the CVRN
To examine the relationship between three prevalent mental health disorders (depression, anxiety disorders, and ADHD), their associated therapies, and outcomes for hypertension, atrial fibrillation and venous thromboembolic disease within the NHLBI-sponsored Cardiovascular Research Network (CVRN). These outcomes will include intermediate markers such as medication adherence and surrogate outcomes (e.g., systolic blood pressure and percentage of time spent at a therapeutic INR), as well as long-term clinical outcomes such as thromboembolic events (e.g., acute myocardial infarction, ischemic stroke, recurrent venous thromboembolism) and major bleeding.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Go, Alan
A Prospective, Randomized, Multi-Center, Double-Blind Trial to Assess the Effectiveness and Safety of Different Durations of Dual Anti-Platelet Therapy (DAPT) in Subjects Undergoing Percutaneous Coronary Intervention with the CYPHER Sirolimus-eluting Coronary Stent (CYPHER Stent) CYPRESS, P09-6301
Funder: Cordis Corp.
Principal Investigator: Lundstrom, Robert
Protocol development with stakeholders to compare the effectiveness of antiplatelet and anticoagulation therapy in patients undergoing coronary interventions
To develop protocol with stakeholders to compare the effectiveness of antiplatelet and anticoagulation therapy in patients undergoing coronary interventions.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Go, Alan
Restless Legs Syndrome and Risk of Cardiovascular Disease in a Managed Care Setting
This is a cohort study where the primary objective is to compare the risk of cardiovascular disease in subjects with restless legs syndrome and matched control subjects.
Funder: GlaxoSmithKline
Principal Investigator: Van Den Eeden, Stephen
Retinopathy in Chronic Renal Insufficiency
This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study proposes to do follow-up digital retinal photographs to assess the incidence and progression of retinal abnormalities and their association with cardiovascular disease and progression of chronic kidney disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Improved Estimates of the Comparative Treatment Effects of CABG and PCI
This ARRA-funded study will expand ongoing work through the joint Kaiser-Stanford American Heart Association Cardiovascular Outcomes Research Center to compare the effectiveness and safety of coronary artery bypass surgery versus percutaneous coronary intervention for the treatment of coronary heart disease using different statistical and analytic strategies to reduce the impact of treatment selection bias and confounding.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Go, Alan
Gender, Obesity, C-Reactive Protein and Oxidative Stress
Epidemiological data and a trial in smokers suggest that Vitamin C supplementation may decrease C-reactive protein, a marker of inflammation associated with heart disease. The current study is a randomized trial of vitamin C versus placebo among obese patients with elevated levels of C-reactive protein.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Corley, Douglas
Development of Cardiovascular Surveillance System in the CVRN
Development of Cardiovascular Surveillance System in the CVRN
Funder: Kaiser Foundation Research Institute
Principal Investigator: Sidney, Stephen
Chronic Renal Insufficiency Cohort Study II
Chronic Renal Insufficiency Cohort Study II
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Management and Outcomes of Heart Failure with Preserved Systolic Function
Management and Outcomes of Heart Failure with Preserved Systolic Function
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Coffee, caffeine, and risk of hospitalization for arrhythmias
Klatsky, A. L.;
Hasan, A. S.;
Armstrong, M. A.;
Udaltsova, N.;
Morton, C.;
15
(3):
19-25
Summer 2011
PubMed abstract
»
ADHD Drugs and Serious Cardiovascular Events in Children and Young
Adults
Cooper, W. O.;
Habel, L. A.;
Sox, C. M.;
Chan, K. A.;
Arbogast, P. G.;
Cheetham, T. C.;
Murray, K. T.;
Quinn, V. P.;
Stein, C. M.;
Callahan, S. T.;
Fireman, B. H.;
Fish, F. A.;
Kirshner, H. S.;
O'Duffy, A.;
Connell, F. A.;
Ray, W. A.;
Nov 1 2011
PubMed abstract
»
Maternal exposure to angiotensin converting enzyme inhibitors in
the first trimester and risk of malformations in offspring: a
retrospective cohort study
Li, D. K.;
Yang, C.;
Andrade, S.;
Tavares, V.;
Ferber, J. R.;
BMJ
343
d5931 (10p)
2011
PubMed abstract
»
FGF23 induces left ventricular hypertrophy
Faul, C.;
Amaral, A. P.;
Oskouei, B.;
Hu, M. C.;
Sloan, A.;
Isakova, T.;
Gutierrez, O. M.;
Aguillon-Prada, R.;
Lincoln, J.;
Hare, J. M.;
Mundel, P.;
Morales, A.;
Scialla, J.;
Fischer, M.;
Soliman, E. Z.;
Chen, J.;
Go, A. S.;
Rosas, S. E.;
Nessel, L.;
Townsend, R. R.;
Feldman, H. I.;
St John Sutton, M.;
Ojo, A.;
Gadegbeku, C.;
Di Marco, G. S.;
Reuter, S.;
Kentrup, D.;
Tiemann, K.;
Brand, M.;
Hill, J. A.;
Moe, O. W.;
Kuro, O. M.;
Kusek, J. W.;
Keane, M. G.;
Wolf, M.;
Oct 10 2011
PubMed abstract
»
Outcomes registry for better informed treatment of atrial
fibrillation: Rationale and design of ORBIT-AF
Piccini, J. P.;
Fraulo, E. S.;
Ansell, J. E.;
Fonarow, G. C.;
Gersh, B. J.;
Go, A. S.;
Hylek, E. M.;
Kowey, P. R.;
Mahaffey, K. W.;
Thomas, L. E.;
Kong, M. H.;
Lopes, R. D.;
Mills, R. M.;
Peterson, E. D.;
162
(4):
606-612 e1
Oct 2011
PubMed abstract
»
Chronic kidney disease and risk for presenting with acute
myocardial infarction versus stable exertional angina in adults
with coronary heart disease
Go, A. S.;
Bansal, N.;
Chandra, M.;
Lathon, P. V.;
Fortmann, S. P.;
Iribarren, C.;
Hsu, C. Y.;
Hlatky, M. A.;
58
(15):
1600-7
Oct 4 2011
PubMed abstract
»
Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease
Go, A. S.;
Bansal, N.;
Chandra, M.;
Lathon, P. V.;
Fortmann, S. P.;
Iribarren, C.;
Hsu, C. Y.;
Hlatky, M. A.;
Journal of the American College of Cardiology
58
(15):
1600-7
Oct 4 2011
PubMed abstract
»
Are vasomotor symptoms associated with alterations in hemostatic
and inflammatory markers? Findings from the Study of Women's Health
Across the Nation
Thurston, R. C.;
El Khoudary, S. R.;
Sutton-Tyrrell, K.;
Crandall, C. J.;
Gold, E.;
Sternfeld, B.;
Selzer, F.;
Matthews, K. A.;
Menopause
Sep 15 2011
PubMed abstract
»
Are vasomotor symptoms associated with alterations in hemostatic
and inflammatory markers? Findings from the Study of Women's Health
Across the Nation
Thurston, R. C.;
El Khoudary, S. R.;
Sutton-Tyrrell, K.;
Crandall, C. J.;
Gold, E.;
Sternfeld, B.;
Selzer, F.;
Matthews, K. A.;
Menopause
Sep 15 2011
PubMed abstract
»
Potential role of differential medication use in explaining excess
risk of cardiovascular events and death associated with chronic
kidney disease: a cohort study
Bansal, N.;
Hsu, C. Y.;
Chandra, M.;
Iribarren, C.;
Fortmann, S. P.;
Hlatky, M. A.;
Go, A. S.;
12
(1):
44(9p)
Sep 14 2011
PubMed abstract
»
Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study
Bansal, N.;
Hsu, C. Y.;
Chandra, M.;
Iribarren, C.;
Fortmann, S. P.;
Hlatky, M. A.;
Go, A. S.;
BMC nephrology
12
(1):
44(9p)
Sep 14 2011
PubMed abstract
»
Genetic variants in novel pathways influence blood pressure and
cardiovascular disease risk
Ehret, G. B.;
Munroe, P. B.;
Rice, K. M.;
,,,;
Johnson, A. D.;
...;
Smith, A. V.;
...;
Abecasis, G. R.;
Chakravarti, A.;
Elliott, P.;
van Duijn, C. M.;
Newton-Cheh, C.;
Levy, D.;
Caulfield, M. J.;
Johnson, T.;
...;
Fortmann, S.;
Assimes, T. L.;
Quertermous, T.;
Go, A.;
Iribarren, C.;
Absher, D.;
Risch, N.;
Myers, R.;
Sidney, S.;
...;
Nature
478
(7367):
103-9
Oct 6 2011
PubMed abstract
»
Mental illness and warfarin use in atrial fibrillation
Walker, G. A.;
Heidenreich, P. A.;
Phibbs, C. S.;
Go, A. S.;
Chiu, V. Y.;
Schmitt, S. K.;
Ananth, L.;
Frayne, S. M.;
17
(9):
617-24
Sep 2011
PubMed abstract
»
Mental illness and warfarin use in atrial fibrillation
Walker, G. A.;
Heidenreich, P. A.;
Phibbs, C. S.;
Go, A. S.;
Chiu, V. Y.;
Schmitt, S. K.;
Ananth, L.;
Frayne, S. M.;
The American journal of managed care
17
(9):
617-24
Sep 2011
PubMed abstract
»
Cardiovascular Disease Among Hispanics and Non-Hispanics in the
Chronic Renal Insufficiency Cohort (CRIC) Study
Ricardo, A. C.;
Lash, J. P.;
Fischer, M. J.;
Lora, C. M.;
Budoff, M.;
Keane, M. G.;
Kusek, J. W.;
Martinez, M.;
Nessel, L.;
Stamos, T.;
Ojo, A.;
Rahman, M.;
Soliman, E. Z.;
Yang, W.;
Feldman, H. I.;
Go, A. S.;
6
(9):
2121-2131
Sep 2011
PubMed abstract
»