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Research

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Biostatistics

The National Cancer Institute defines biostatistics as the "science of collecting and analyzing biologic or health data using statistical methods."  Division of Research biostatisticians play a vital role in research design and the transformation of data into evidence for the improvement of medical care and the public's health.

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Case-centered Logistic Regression

This project, through a series of studies, describes a new way to fit multiplicative intensity models, including stratified Cox models, using familiar software. The research shows that it can reduce computational burdens, simplify examination of adverse events due to a vaccine or other exposure, clarify time-by-treatment interactions, and alleviate privacy concerns in multi-site studies.
Funder: The Permanente Medical Group
Principal Investigator: Fireman, Bruce

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Exact Sequential Analysis

This project develops statistical methods for sequential analysis and the software to implement them. 
Funder: Centers for Disease Control and Prevention
Principal Investigator: Fireman, Bruce

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Total Serum Bilirubin Exceeding Exchange Transfusion Thresholds in the Setting of Universal Screening

Flaherman, V. J.; Kuzniewicz, M. W.; Escobar, G. J.; Newman, T. B.;
 
Nov 30 2011
PubMed abstract  »

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Differentiating Population Stratification from Genotyping Error Using Family Data

Sebro, R.; Lange, C.; Laird, N. M.; Rogus, J. J.; Risch, N. J.;
Annals of human genetics  
Nov 23 2011
PubMed abstract  »

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The impact of maternal characteristics on the moderately premature infant: an antenatal maternal transport clinical prediction rule

Dukhovny, D.; Dukhovny, S.; Pursley, D. M.; Escobar, G. J.; McCormick, M. C.; Mao, W. Y.; Zupancic, J. A.;
 
Nov 10 2011
PubMed abstract  »

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Estimating the Probability of Neonatal Early-Onset Infection on the Basis of Maternal Risk Factors

Puopolo, K. M.; Draper, D.; Wi, S.; Newman, T. B.; Zupancic, J.; Lieberman, E.; Smith, M.; Escobar, G. J.;
Pediatrics  
Oct 24 2011
PubMed abstract  »

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Validation of the Stroke Prognostic Instrument-II in a Large, Modern, Community-Based Cohort of Ischemic Stroke Survivors

Navi, B. B.; Kamel, H.; Sidney, S.; Klingman, J. G.; Nguyen-Huynh, M. N.; Johnston, S. C.;
 
Sep 29 2011
PubMed abstract  »

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Methods for Assessing Fracture Risk Prediction Models: Experience With FRAX in a Large Integrated Health Care Delivery System

Pressman, A. R.; Lo, J. C.; Chandra, M.; Ettinger, B.;
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry  
Sep 28 2011
PubMed abstract  »

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Validation of the Stroke Prognostic Instrument-II in a Large, Modern, Community-Based Cohort of Ischemic Stroke Survivors

Navi, B. B.; Kamel, H.; Sidney, S.; Klingman, J. G.; Nguyen-Huynh, M. N.; Johnston, S. C.;
Stroke; a journal of cerebral circulation  
Sep 29 2011
PubMed abstract  »

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Methods for Assessing Fracture Risk Prediction Models: Experience With FRAX in a Large Integrated Health Care Delivery System

Pressman, A. R.; Lo, J. C.; Chandra, M.; Ettinger, B.;
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 
Sep 28 2011
PubMed abstract  »

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A case-control study of asphalt and tar exposure and lung cancer in minorities

McClean, M. D.; Kelsey, K. T.; Sison, J. D.; Quesenberry, C. P., Jr.; Wrensch, M. R.; Wiencke, J. K.;
 
Aug 31 2011
PubMed abstract  »

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Predictive Values of Framingham Risk and Coronary Artery Calcium Scores in the Detection of Obstructive CAD in Patients with Normal SPECT

Jang, J. J.; Krishnaswami, A.; Hung, Y. Y.;
Angiology  
Aug 25 2011
PubMed abstract  »

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Epidemiology of peripartum cardiomyopathy: incidence, predictors, and outcomes

Gunderson, E. P.; Croen, L. A.; Chiang, V.; Yoshida, C. K.; Walton, D.; Go, A. S.;
Obstet Gynecol   118 (3): 583-91
Sep 2011
PubMed abstract  »

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Evaluation of a Cell Phone-Based Physical Activity Diary

Sternfeld, B.; Jiang, S. F.; Picchi, T.; Chasan-Taber, L.; Ainsworth, B.; Quesenberry, C. P., Jr.;
Med Sci Sports Exerc  
Aug 12 2011
PubMed abstract  »

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Candidate Genes and Risk for Cerebral Palsy: a Population-Based Study

Wu, Y. W.; Croen, L. A.; Vanderwerf, A.; Gelfand, A. A.; Torres, A. R.;
Pediatr Res  
Aug 18 2011
PubMed abstract  »

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Risk Factors for Tuberculosis After Highly Active Antiretroviral Therapy Initiation in the United States and Canada: Implications for Tuberculosis Screening

Sterling, T. R.; Lau, B.; Zhang, J.; Freeman, A.; Bosch, R. J.; Brooks, J. T.; Deeks, S. G.; French, A.; Gange, S.; Gebo, K. A.; John Gill, M.; Horberg, M. A.; Jacobson, L. P.; Kirk, G. D.; Kitahata, M. M.; Klein, M. B.; Martin, J. N.; Rodriguez, B.; Silverberg, M. J.; Willig, J. H.; Eron, J. J.; Goedert, J. J.; Hogg, R. S.; Justice, A. C.; McKaig, R. G.; Napravnik, S.; Thorne, J.; Moore, R. D.;
J Infect Dis   204 (6): 893-901
Sep 2011
PubMed abstract  »

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Urinary incontinence self-report questions: reproducibility and agreement with bladder diary

Bradley, C. S.; Brown, J. S.; Van Den Eeden, S. K.; Schembri, M.; Ragins, A.; Thom, D. H.;
Int Urogynecol J Pelvic Floor Dysfunct  
Jul 28 2011
PubMed abstract  »