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Research

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Autoimmune Diseases

Diagnosis can be difficult if the first symptoms are fatigue, muscle ache and low fever. This is often the case with autoimmune diseases, which are caused by inappropriate immune responses. We are investigating the causes and treatments of these diseases, which tend to run in families and disproportionately affect African-American, Hispanic-American, and Native-American women.

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Safety Assessment of Anti-TNF Agents Used in Autoimmune Disease

This study will identify the risk of developing serious adverse events (e.g., infections and cancer), while using biologic therapies for the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Herrinton, Lisa

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Kaiser Permanente Autoimmune Disease Registry

This study establishes the Kaiser Permanente Autoimmune Disease Registry, containing comprehensive clinical information for a large, diverse population with access to DNA for future genotyping and functional assays.
Funder: Nat. Inst. of Allergy and Infectious Diseases
Principal Investigator: Herrinton, Lisa

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Fetal Risks of Immunosuppressive Drugs in Autoimmune Disease

The primary aim of this study is to examine whether exposure to biologics medication during pregnancy increases the risk of adverse birth outcomes.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Li, De-Kun

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Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis

Kawai, V. K.; Grijalva, C. G.; Arbogast, P. G.; Curtis, J. R.; Solomon, D. H.; Delzell, E.; Chen, L.; Ouellet-Hellstrom, R.; Herrinton, L.; Liu, L.; Mitchel, E. F., Jr.; Stein, C. M.; Griffin, M. R.;
Arthritis Care Res   63 (10): 1415-24
Oct 2011
PubMed abstract  »

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Initiation of Tumor Necrosis Factor-alpha Antagonists and the Risk of Hospitalization for Infection in Patients With Autoimmune Diseases

Grijalva, C. G.; Chen, L.; Delzell, E.; Baddley, J. W.; Beukelman, T.; Winthrop, K. L.; Griffin, M. R.; Herrinton, L. J.; Liu, L.; Ouellet-Hellstrom, R.; Patkar, N. M.; Solomon, D. H.; Lewis, J. D.; Xie, F.; Saag, K. G.; Curtis, J. R.;
 
Nov 6 2011
PubMed abstract  »

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Surveillance of Autoimmune Conditions following Routine Use of Quadrivalent Human Papillomavirus Vaccine

Chao, C.; Klein, N. P.; Velicer, C. M.; Sy, L. S.; Slezak, J. M.; Takhar, H.; Ackerson, B.; Cheetham, T. C.; Hansen, J.; Deosaransingh, K.; Emery, M.; Liaw, K. L.; Jacobsen, S. J.;
 
Oct 4 2011
PubMed abstract  »

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Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems

Herrinton, L. J.; Curtis, J. R.; Chen, L.; Liu, L.; Delzell, E.; Lewis, J. D.; Solomon, D. H.; Griffin, M. R.; Ouellet-Hellstom, R.; Beukelman, T.; Grijalva, C. G.; Haynes, K.; Kuriya, B.; Lii, J.; Mitchel, E.; Patkar, N.; Rassen, J.; Winthrop, K. L.; Nourjah, P.; Saag, K. G.;
Pharmacoepidemiology and Drug Safety  
Sep 15 2011
PubMed abstract  »

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Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems

Herrinton, L. J.; Curtis, J. R.; Chen, L.; Liu, L.; Delzell, E.; Lewis, J. D.; Solomon, D. H.; Griffin, M. R.; Ouellet-Hellstom, R.; Beukelman, T.; Grijalva, C. G.; Haynes, K.; Kuriya, B.; Lii, J.; Mitchel, E.; Patkar, N.; Rassen, J.; Winthrop, K. L.; Nourjah, P.; Saag, K. G.;
Pharmacoepidemiology and Drug Safety 
Sep 15 2011
PubMed abstract  »

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Sawcer, S.; Hellenthal, G.; Pirinen, M.; Spencer, C. C.; ...; Barcellos, L. F.; ...; Bernstein, A.; ...; Schaefer, C. A.; ...; Shen, L.; Simms-Acuna, B.; ...; Donnelly, P.; Compston, A.;
Nature   476 (7359): 214-9
Aug 11 2011
PubMed abstract  »

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Common variants in P2RY11 are associated with narcolepsy

Kornum, B. R.; Kawashima, M.; Faraco, J.; Lin, L.; Rico, T. J.; Hesselson, S.; Axtell, R. C.; Kuipers, H.; Weiner, K.; Hamacher, A.; Kassack, M. U.; Han, F.; Knudsen, S.; Li, J.; Dong, X.; Winkelmann, J.; Plazzi, G.; Nevsimalova, S.; Hong, S. C.; Honda, Y.; Honda, M.; Hogl, B.; Ton, T. G.; Montplaisir, J.; Bourgin, P.; Kemlink, D.; Huang, Y. S.; Warby, S.; Einen, M.; Eshragh, J. L.; Miyagawa, T.; Desautels, A.; Ruppert, E.; Hesla, P. E.; Poli, F.; Pizza, F.; Frauscher, B.; Jeong, J. H.; Lee, S. P.; Strohl, K. P.; Longstreth, W. T., Jr.; Kvale, M.; Dobrovolna, M.; Ohayon, M. M.; Nepom, G. T.; Wichmann, H. E.; Rouleau, G. A.; Gieger, C.; Levinson, D. F.; Gejman, P. V.; Meitinger, T.; Peppard, P.; Young, T.; Jennum, P.; Steinman, L.; Tokunaga, K.; Kwok, P. Y.; Risch, N.; Hallmayer, J.; Mignot, E.;
Nat Genet  
Dec 19 2010
PubMed abstract  »

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Autoimmune diseases prior to the diagnosis of multiple sclerosis: a population-based case-control study

Langer-Gould, A.; Albers, K. B.; Van Den Eeden, S. K.; Nelson, L. M.;
Mult Scler  16 (7): 855-61
Jul 2010
PubMed abstract  »

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Rates of autoimmune diseases in Kaiser Permanente for use in vaccine adverse event safety studies

Klein, N. P.; Ray, P.; Carpenter, D.; Hansen, J.; Lewis, E.; Fireman, B.; Black, S.; Galindo, C.; Schmidt, J.; Baxter, R.;
Vaccine   28 (4): 1062-8
Jan 22 2010
PubMed abstract  »

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Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes

Ashwood, P.; Enstrom, A.; Krakowiak, P.; Hertz-Picciotto, I.; Hansen, R. L.; Croen, L. A.; Ozonoff, S.; Pessah, I. N.; Van de Water, J.;
J Neuroimmunol   204 (1-2): 149-53
Nov 15 2008
PubMed abstract  »

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Risk of lymphoproliferative cancer among patients with severe rheumatoid arthritis, 1996-2002

Herrinton, L. J.; Liu, L.; Shoor, S.; Mines, D.;
Ann Rheum Dis   67 (4): 574-5
Apr 2008
PubMed abstract  »

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The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association

Bronson, P. G.; Criswell, L. A.; Barcellos, L. F.;
Ann Rheum Dis   67 (7): 933-6
Jul 2008
PubMed abstract  »

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Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization

Weng, X.; Liu, L.; Barcellos, L. F.; Allison, J. E.; Herrinton, L. J.;
Am J Gastroenterol   102 (7): 1429-35
Jul 2007
PubMed abstract  »

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Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype?

Ashwood, P.; Kwong, C.; Hansen, R.; Hertz-Picciotto, I.; Croen, L.; Krakowiak, P.; Walker, W.; Pessah, I. N.; Van de Water, J.;
J Autism Dev Disord   38 (1): 169-75
Jan 2008
PubMed abstract  »

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Hepatitis B vaccine and risk of autoimmune thyroid disease: a Vaccine Safety Datalink study

Yu, O.; Bohlke, K.; Hanson, C. A.; Delaney, K.; Rees, T. G.; Zavitkovsky, A.; Ray, P.; Mullooly, J.; Black, S. B.; Benson, P.; Thompson, W. W.; Davis, R. L.; Jackson, L. A.;
Pharmacoepidemiol Drug Saf   16 (7): 736-45
Jul 2007
PubMed abstract  »