Safety Assessment of Anti-TNF Agents Used in Autoimmune Disease
This study will identify the risk of developing serious adverse events (e.g., infections and cancer), while using biologic therapies for the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Herrinton, Lisa
Kaiser Permanente Autoimmune Disease Registry
This study establishes the Kaiser Permanente Autoimmune Disease Registry, containing comprehensive clinical information for a large, diverse population with access to DNA for future genotyping and functional assays.
Funder: Nat. Inst. of Allergy and Infectious Diseases
Principal Investigator: Herrinton, Lisa
Fetal Risks of Immunosuppressive Drugs in Autoimmune Disease
The primary aim of this study is to examine whether exposure to biologics medication during pregnancy increases the risk of adverse birth outcomes.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Li, De-Kun
Changes in cotherapies after initiation of disease-modifying
antirheumatic drug therapy in patients with rheumatoid arthritis
Kawai, V. K.;
Grijalva, C. G.;
Arbogast, P. G.;
Curtis, J. R.;
Solomon, D. H.;
Delzell, E.;
Chen, L.;
Ouellet-Hellstrom, R.;
Herrinton, L.;
Liu, L.;
Mitchel, E. F., Jr.;
Stein, C. M.;
Griffin, M. R.;
Arthritis Care Res
63
(10):
1415-24
Oct 2011
PubMed abstract
»
Initiation of Tumor Necrosis Factor-alpha Antagonists and the Risk
of Hospitalization for Infection in Patients With Autoimmune
Diseases
Grijalva, C. G.;
Chen, L.;
Delzell, E.;
Baddley, J. W.;
Beukelman, T.;
Winthrop, K. L.;
Griffin, M. R.;
Herrinton, L. J.;
Liu, L.;
Ouellet-Hellstrom, R.;
Patkar, N. M.;
Solomon, D. H.;
Lewis, J. D.;
Xie, F.;
Saag, K. G.;
Curtis, J. R.;
Nov 6 2011
PubMed abstract
»
Surveillance of Autoimmune Conditions following Routine Use of
Quadrivalent Human Papillomavirus Vaccine
Chao, C.;
Klein, N. P.;
Velicer, C. M.;
Sy, L. S.;
Slezak, J. M.;
Takhar, H.;
Ackerson, B.;
Cheetham, T. C.;
Hansen, J.;
Deosaransingh, K.;
Emery, M.;
Liaw, K. L.;
Jacobsen, S. J.;
Oct 4 2011
PubMed abstract
»
Study design for a comprehensive assessment of biologic safety
using multiple healthcare data systems
Herrinton, L. J.;
Curtis, J. R.;
Chen, L.;
Liu, L.;
Delzell, E.;
Lewis, J. D.;
Solomon, D. H.;
Griffin, M. R.;
Ouellet-Hellstom, R.;
Beukelman, T.;
Grijalva, C. G.;
Haynes, K.;
Kuriya, B.;
Lii, J.;
Mitchel, E.;
Patkar, N.;
Rassen, J.;
Winthrop, K. L.;
Nourjah, P.;
Saag, K. G.;
Pharmacoepidemiology and Drug Safety
Sep 15 2011
PubMed abstract
»
Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems
Herrinton, L. J.;
Curtis, J. R.;
Chen, L.;
Liu, L.;
Delzell, E.;
Lewis, J. D.;
Solomon, D. H.;
Griffin, M. R.;
Ouellet-Hellstom, R.;
Beukelman, T.;
Grijalva, C. G.;
Haynes, K.;
Kuriya, B.;
Lii, J.;
Mitchel, E.;
Patkar, N.;
Rassen, J.;
Winthrop, K. L.;
Nourjah, P.;
Saag, K. G.;
Pharmacoepidemiology and Drug Safety
Sep 15 2011
PubMed abstract
»
Genetic risk and a primary role for cell-mediated immune mechanisms
in multiple sclerosis
Sawcer, S.;
Hellenthal, G.;
Pirinen, M.;
Spencer, C. C.;
...;
Barcellos, L. F.;
...;
Bernstein, A.;
...;
Schaefer, C. A.;
...;
Shen, L.;
Simms-Acuna, B.;
...;
Donnelly, P.;
Compston, A.;
Nature
476
(7359):
214-9
Aug 11 2011
PubMed abstract
»
Common variants in P2RY11 are associated with narcolepsy
Kornum, B. R.;
Kawashima, M.;
Faraco, J.;
Lin, L.;
Rico, T. J.;
Hesselson, S.;
Axtell, R. C.;
Kuipers, H.;
Weiner, K.;
Hamacher, A.;
Kassack, M. U.;
Han, F.;
Knudsen, S.;
Li, J.;
Dong, X.;
Winkelmann, J.;
Plazzi, G.;
Nevsimalova, S.;
Hong, S. C.;
Honda, Y.;
Honda, M.;
Hogl, B.;
Ton, T. G.;
Montplaisir, J.;
Bourgin, P.;
Kemlink, D.;
Huang, Y. S.;
Warby, S.;
Einen, M.;
Eshragh, J. L.;
Miyagawa, T.;
Desautels, A.;
Ruppert, E.;
Hesla, P. E.;
Poli, F.;
Pizza, F.;
Frauscher, B.;
Jeong, J. H.;
Lee, S. P.;
Strohl, K. P.;
Longstreth, W. T., Jr.;
Kvale, M.;
Dobrovolna, M.;
Ohayon, M. M.;
Nepom, G. T.;
Wichmann, H. E.;
Rouleau, G. A.;
Gieger, C.;
Levinson, D. F.;
Gejman, P. V.;
Meitinger, T.;
Peppard, P.;
Young, T.;
Jennum, P.;
Steinman, L.;
Tokunaga, K.;
Kwok, P. Y.;
Risch, N.;
Hallmayer, J.;
Mignot, E.;
Nat Genet
Dec 19 2010
PubMed abstract
»
Autoimmune diseases prior to the diagnosis of multiple sclerosis: a population-based case-control study
Langer-Gould, A.;
Albers, K. B.;
Van Den Eeden, S. K.;
Nelson, L. M.;
Mult Scler
16
(7):
855-61
Jul 2010
PubMed abstract
»
Rates of autoimmune diseases in Kaiser Permanente for use in
vaccine adverse event safety studies
Klein, N. P.;
Ray, P.;
Carpenter, D.;
Hansen, J.;
Lewis, E.;
Fireman, B.;
Black, S.;
Galindo, C.;
Schmidt, J.;
Baxter, R.;
Vaccine
28
(4):
1062-8
Jan 22 2010
PubMed abstract
»
Decreased transforming growth factor beta1 in autism: a potential
link between immune dysregulation and impairment in clinical
behavioral outcomes
Ashwood, P.;
Enstrom, A.;
Krakowiak, P.;
Hertz-Picciotto, I.;
Hansen, R. L.;
Croen, L. A.;
Ozonoff, S.;
Pessah, I. N.;
Van de Water, J.;
J Neuroimmunol
204
(1-2):
149-53
Nov 15 2008
PubMed abstract
»
Risk of lymphoproliferative cancer among patients with severe
rheumatoid arthritis, 1996-2002
Herrinton, L. J.;
Liu, L.;
Shoor, S.;
Mines, D.;
Ann Rheum Dis
67
(4):
574-5
Apr 2008
PubMed abstract
»
The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis:
a meta-analysis of 6861 patients and 9270 controls reveals no
evidence for association
Bronson, P. G.;
Criswell, L. A.;
Barcellos, L. F.;
Ann Rheum Dis
67
(7):
933-6
Jul 2008
PubMed abstract
»
Clustering of inflammatory bowel disease with immune mediated
diseases among members of a northern california-managed care
organization
Weng, X.;
Liu, L.;
Barcellos, L. F.;
Allison, J. E.;
Herrinton, L. J.;
Am J Gastroenterol
102
(7):
1429-35
Jul 2007
PubMed abstract
»
Brief report: plasma leptin levels are elevated in autism:
association with early onset phenotype?
Ashwood, P.;
Kwong, C.;
Hansen, R.;
Hertz-Picciotto, I.;
Croen, L.;
Krakowiak, P.;
Walker, W.;
Pessah, I. N.;
Van de Water, J.;
J Autism Dev Disord
38
(1):
169-75
Jan 2008
PubMed abstract
»
Hepatitis B vaccine and risk of autoimmune thyroid disease: a
Vaccine Safety Datalink study
Yu, O.;
Bohlke, K.;
Hanson, C. A.;
Delaney, K.;
Rees, T. G.;
Zavitkovsky, A.;
Ray, P.;
Mullooly, J.;
Black, S. B.;
Benson, P.;
Thompson, W. W.;
Davis, R. L.;
Jackson, L. A.;
Pharmacoepidemiol Drug Saf
16
(7):
736-45
Jul 2007
PubMed abstract
»