Diverse Autism Registry for Effectiveness Studies
The goal of the study is to create a large, comprehensive and dynamic
autism spectrum disorder (ASD) registry across several integrated health
systems. The first phase of the study will look at variability across
the participating health plans in the prevalence of ASD, in medical and
psychiatric co-morbidities in the ASD population, and in the use of
psychotropic medications to treat children and adolescents with ASDs.
The second phase will look at different treatment approaches, and
treatment burdens for families of children with ASD, and parental
perceptions of the efficacy of different treatments. During the second
phase of the study, parents of children diagnosed with an ASD who are
Kaiser Permanente members will be invited to complete a Web survey and
contribute a blood or saliva sample for future ASD research.
Funder: National Institute of Mental Health
Principal Investigator: Croen, Lisa
Autism Blue Sky Conference
Funder: Garfield Memorial Fund
Principal Investigator: Croen, Lisa
Prenatal and Neonatal Biologic Markers for Autism (EMA)
The proposed study will continue an investigation of prenatal and newborn biologic markers for autism previously funded by NIH. The goal of the new study is to further investigate the role of prenatal and newborn immunologic factors, genetic susceptibility factors, and environmental exposures by evaluating stored prenatal (maternal) and newborn blood specimens for children with autism, children with other developmental disabilities, and population controls. We anticipate that the results of this study will contribute to identifying factors that increase the risk for autism and may lead to eventual prevention of autism and related disorders.
Funder: Nat. Inst. of Environmental Health Sciences
Principal Investigator: Croen, Lisa
Environment, the Perinatal Epigenome and Risk for Autism and Related Disorders
This goal of this study is to understand the relationship between environmental exposures, epigenetics, and risk for autism. Our proposal will address four main themes: (1) the effects of pre and perinatal exposures on genome-wide methylation in mother, father, and child, (2) the familiality of DNAm and DNAm changes, (3) the effects of DNAm on child development and autism risk, and (4) the integration of GWAS SNP and CNV data already funded for this project with these epigenetic data to capture genetic and epigenetic effects in the epidemiology of autism.
Funder: National Cancer Institute
Principal Investigator: Croen, Lisa
Prenatal and Neonatal Biologic Markers for Autism
The study will continue an investigation of prenatal and newborn biologic markers for autism previously funded by NIH. The goal of the new study is to further investigate the role of prenatal and newborn immunologic factors, genetic susceptibility factors, and environmental exposures by evaluating stored prenatal (maternal) and newborn blood specimens for children with autism, children with other developmental disabilities, and population controls.
Funder: Kaiser Foundation Health Plan
Principal Investigator: Croen, Lisa
The IBIS-EARLI Collaboration
This proposal will form a collaboration between the EARLI Network and the IBIS Network, two Autism Centers of Excellence Networks focusing on the longitudinal study of high-risk siblings of children with autistic spectrum disorders.
Funder: Autism Speaks
Principal Investigator: Croen, Lisa
Autism Intervention Research Network on Physical Health (AIR-P Network)
The AIR-P Network will: conduct research on evidence-based practices for interventions to improve the physical health and well-being of children and adolescents with ASD and other developmental disabilities; develop evidence-based guidelines and validate tools for interventions to improve the health care of children and adolescents with ASD and other developmental disabilities; and disseminate critical information on its research findings, guidelines developed, and validated tools to health professionals and the public, especially families impacted by ASD and other developmental disabilities.
Funder: Health Resources and Services Administration
Principal Investigator: Croen, Lisa
Early Biologic Markers for Autism (EMA)
This case-control study of autism is examining several biologic markers of disease susceptibility and exposure in maternal blood specimens collected during midpregnancy and neonatal specimens collected at birth.
Funder: Autism Speaks
Principal Investigator: Croen, Lisa
Early Autism Risks Longitudinal Investigation (EARLI) Network
This Autism Center of Excellence (ACE) Network is investigating possible risk factors and biologic indicators for autism spectrum disorders (ASD) during prenatal, neonatal, and early postnatal development. A prospective study will enroll 1,200 mothers of children with autism at the start of a new pregnancy and follow them and the new baby through 36 months post-delivery.
Funder: Nat. Inst. of Environmental Health Sciences
Principal Investigator: Croen, Lisa
Cooperative Multi-center Program for Research and Treatment of Autism (ATN)
This project aims to join the Autism Treatment Network, enroll a large sample of children with autism from the well-established programs at Kaiser Permanente, and advance the mission of combining outstanding research and clinical care by conducting studies to evaluate the use and effectiveness of medical treatments and complementary and alternative therapies, which have a high prevalence of use in this population.
Funder: Autism Speaks and Autism Treatment Network
Principal Investigator: Croen, Lisa
California Monitoring of Early Childhood Autism (CA-MECA)
This study aims to find out what the prevalence of autism spectrum disorders is in children under the age of four in Santa Clara County.
Funder: CDC and CDHS
Principal Investigator: Croen, Lisa
National CADDRE Study: Child Development and Autism (SEED)
This multi-site collaborative epidemiologic study investigates risk and causal factors for Autism Spectrum Disorders (ASD) and phenotypic subgroups of ASD using a population-based case-cohort study design.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Croen, Lisa
A California Population-based Twin Study of Autism (CATS)
The project aims to construct a large, population-based autism twin registry and to study the genetic influence on specific autism behavioral and cognitive characteristics and the relationships between these characteristics.
Funder: National Institute of Mental Health
Principal Investigator: Croen, Lisa
Prenatal exposure to beta2-adrenergic receptor agonists and risk of
autism spectrum disorders
Croen, L. A.;
Connors, S. L.;
Matevia, M.;
Qian, Y.;
Newschaffer, C.;
Zimmerman, A. W.;
Journal of neurodevelopmental disorders
Aug 27 2011
PubMed abstract
»
Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving
birth to a child with autism: a case-control study
Goines, P. E.;
Croen, L. A.;
Braunschweig, D.;
Yoshida, C. K.;
Grether, J.;
Hansen, R.;
Kharrazi, M.;
Ashwood, P.;
Van de Water, J.;
Mol Autism
2
(1):
13
Aug 2 2011
PubMed abstract
»
Antidepressant Use During Pregnancy and Childhood Autism Spectrum
Disorders
Croen, L. A.;
Grether, J. K.;
Yoshida, C. K.;
Odouli, R.;
Hendrick, V.;
Arch Gen Psychiatry
Jul 4 2011
PubMed abstract
»
Genetic Heritability and Shared Environmental Factors Among Twin
Pairs With Autism
Hallmayer, J.;
Cleveland, S.;
Torres, A.;
Phillips, J.;
Cohen, B.;
Torigoe, T.;
Miller, J.;
Fedele, A.;
Collins, J.;
Smith, K.;
Lotspeich, L.;
Croen, L. A.;
Ozonoff, S.;
Lajonchere, C.;
Grether, J. K.;
Risch, N.;
Arch Gen Psychiatry
Jul 4 2011
PubMed abstract
»
Jaundice-autism link unconvincing
Newman, T. B.;
Croen, L. A.;
Pediatrics
127
(3):
e858-9
Mar 2011
PubMed abstract
»
Birth Prevalence of Autism Spectrum Disorders in the San Francisco
Bay Area by Demographic and Ascertainment Source Characteristics
Windham, G. C.;
Anderson, M. C.;
Croen, L. A.;
Smith, K. S.;
Collins, J.;
Grether, J. K.;
J Autism Dev Disord
Dec 14 2010
PubMed abstract
»
Neonatally measured immunoglobulins and risk of autism
Grether, J. K.;
Croen, L. A.;
Anderson, M. C.;
Nelson, K. B.;
Yolken, R. H.;
Autism Res
3
(6):
323-32
Dec 2010
PubMed abstract
»
Prenatal and Infant Exposure to Thimerosal From Vaccines and
Immunoglobulins and Risk of Autism
Price, C. S.;
Thompson, W. W.;
Goodson, B.;
Weintraub, E. S.;
Croen, L. A.;
Hinrichsen, V. L.;
Marcy, M.;
Robertson, A.;
Eriksen, E.;
Lewis, E.;
Bernal, P.;
Shay, D.;
Davis, R. L.;
Destefano, F.;
Pediatrics
Sep 13 2010
PubMed abstract
»
Risk of Autism and Increasing Maternal and Paternal Age in a Large
North American Population
Grether, J. K.;
Anderson, M. C.;
Croen, L. A.;
Smith, D.;
Windham, G. C.;
Am J Epidemiol
Sep 25 2009
PubMed abstract
»
Investigation of Shifts in Autism Reporting in the California
Department of Developmental Services
Grether, J. K.;
Rosen, N. J.;
Smith, K. S.;
Croen, L. A.;
J Autism Dev Disord
May 29 2009
PubMed abstract
»
Reduced levels of immunoglobulin in children with autism correlates
with behavioral symptoms
Heuer, L.;
Ashwood, P.;
Schauer, J.;
Goines, P.;
Krakowiak, P.;
Hertz-Picciotto, I.;
Hansen, R.;
Croen, L. A.;
Pessah, I. N.;
Van de Water, J.;
Autism Res
1
(5):
275-83
Oct 2008
PubMed abstract
»
Brain-derived neurotrophic factor and autism: maternal and infant
peripheral blood levels in the Early Markers for Autism (EMA) Study
Croen, L. A.;
Goines, P.;
Braunschweig, D.;
Yolken, R.;
Yoshida, C. K.;
Grether, J. K.;
Fireman, B.;
Kharrazi, M.;
Hansen, R. L.;
Van de Water, J.;
Autism Res
1
(2):
130-7
Apr 2008
PubMed abstract
»
Decreased transforming growth factor beta1 in autism: a potential
link between immune dysregulation and impairment in clinical
behavioral outcomes
Ashwood, P.;
Enstrom, A.;
Krakowiak, P.;
Hertz-Picciotto, I.;
Hansen, R. L.;
Croen, L. A.;
Ozonoff, S.;
Pessah, I. N.;
Van de Water, J.;
J Neuroimmunol
204
(1-2):
149-53
Nov 15 2008
PubMed abstract
»
Maternal Rh D status, anti-D immune globulin exposure during
pregnancy, and risk of autism spectrum disorders
Croen, L. A.;
Matevia, M.;
Yoshida, C. K.;
Grether, J. K.;
Am J Obstet Gynecol
199
(3):
234 e1-6
Sep 2008
PubMed abstract
»
Sleep problems in children with autism spectrum disorders,
developmental delays, and typical development: a population-based
study
Krakowiak, P.;
Goodlin-Jones, B.;
Hertz-Picciotto, I.;
Croen, L. A.;
Hansen, R. L.;
J Sleep Res
17
(2):
197-206
Jun 2008
PubMed abstract
»