Epidemiology: Oxidative Stress and Early Atherosclerosis
The renewal of this study utilizes and expands the infrastructure of the CARDIA year 25 examination planned for 2010-2011 to obtain additional blood and urine samples and to perform additional biochemical analyses to elucidate early stages in the pathogenesis of CVD and etiologically related conditions.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
Longitudinal Changes in Pericardial Adiposity and Subclinical Atherosclerosis
The main goal of this CARDIA ancillary is to measure coronary atherosclerosis during the year 25 exam in 2010-11 using 64 channel cardiac CT in at least 90% of the CARDIA study examinees.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
Epilepsy after Pediatric Stroke: A Population-based Study
This is retrospective cohort study with the overall objective of determining the incidence and predictors of epilepsy after stroke in neonates and children. We will use a previously identified cohort of 492 children with stroke in the KP population (1993-2007). We will identify cases with epilepsy through electronic searches of diagnostic databases, and confirm the epilepsy diagnosis through chart review.
Funder: Univ. of California, San Francisco Project Grant
Principal Investigator: Sidney, Stephen
Effect of Race-ethnicity on Anti-Hypertensive Therapy and Blood Pressure Control in Patients with Ischemic Stroke
The specific aims of this study are to: 1) determine in the QUISP cohort the factors that could explain why African Americans have poorer blood pressure control compared to other races by examining potential barriers among patients with acute ischemic stroke in a large racially-diverse cohort, and 2) to determine to what extent failure to control blood pressure could account for the difference in 6 month post-stroke risk in recurrent stroke among the different races.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen
Development of Cardiovascular Surveillance System in the CVRN
Development of Cardiovascular Surveillance System in the CVRN
Funder: Kaiser Foundation Research Institute
Principal Investigator: Sidney, Stephen
Development of Clinical Prediction Rules to Predict Risk of Adverse Outcomes in Dizzy Emergency Department Patients
The primary goal of this study is to utilize electronic medical records to follow a cohort of Kaiser Permanente Northern California patients who present to the emergency department with the chief complaint of dizziness for subsequent adverse cerebrovascular and cardiovascular outcomes. Data on these patients will be developed into a clinical prediction rule to assess the risk of adverse outcomes at the initial emergency department presentation.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen
Health Outcomes of Bariatric Surgery in Individuals with Type 2 Diabetes
This study will examine both the short- and long-term diabetes specific outcomes for obese individuals with type 2 diabetes who have undergone bariatric surgery versus individuals who have been treated nonsurgically.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Sidney, Stephen
Combined Hormonal Contraceptive (CHC) Drugs: Thromboembolic Disease and Death Outcomes
This study evaluates use of OE, Yasmin, the NuvaRing and comparator contraceptive product(s) in a population of new users (incident cohort) to assess the public health impact, patterns of use, and eventually, the behavioral and environmental factors related to use that could place a woman at greater risk for a thromboembolic event and/or death.
Funder: Food and Drug Administration
Principal Investigator: Sidney, Stephen
Epidemiology and Mechanisms of ECG Abnormalities: Young Adulthood to Middle Age
This multi-center collaborative study determines the prevalence of ECG abnormalities in CARDIA participants at 3 points in time (years 0, 7 and 20) and the relationship of nonspecific ST segment T wave abnormalities to cardiovascular (CVD) risk factors, subclinical cardiac disease, and incident diabetes and CVD events.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
The Burden of Childhood Stroke: Financial Costs and Health-related Quality of Life
This study measures utility scores for childhood/neonatal stroke from "societal" and from "patient" perspectives by interviewing parents of "at risk" children and parents of children that have suffered stroke.
Funder: American Heart Association
Principal Investigator: Sidney, Stephen
The Role of Infection in Childhood Stroke
This study determines whether infection is a risk factor for childhood stroke, including both first stroke and stroke recurrence, based on medical record review and structured interview of stroke cases (or surrogates) and age-matched controls randomly selected.
Funder: Nat. Inst. of Neurological Disorders and Stroke
Principal Investigator: Sidney, Stephen
Acute Outcomes and Management of TIA with Carotid Disease
This study determines the short-term stroke risk and death among patients with an emergency department diagnosis of TIA and severe internal carotid artery (ICA) with those with TIA but no severe stenosis.
Funder: Nat. Inst. of Neurological Disorders and Stroke
Principal Investigator: Sidney, Stephen
20 Year Changes in Fitness and Cardiovascular Disease Risk
This study aims to understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of obesity, the metabolic syndrome, and subclinical CVD.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
Acute Coronary Syndrome
This study determines the total costs and clinical outcomes of patients for 12-months after hospitalization with acute coronary syndrome (ACS) during the years 1999 to 2000.
Funder: Eli Lilly
Principal Investigator: Sidney, Stephen
Cornary Artery Risk Development in Young Adults (CARDIA)
This study describes the distribution of coronary heart disease risk factors in a biracial cohort of men and women aged 18 to 30 years at entry; and identifies habits, behaviors, and lifestyles that are associated with initial levels of risk factors and with the evolution of risk factors.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen