Monique M. Hedderson, PhD

Monique M. Hedderson, PhD Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3580 (phone)
monique.m.hedderson@kp.org

Monique M. Hedderson, PhD, is a staff scientist at the Kaiser Permanente Northern California Division of Research. She received her master's in public health from the University of Washington in 2000 and her PhD in epidemiology from the University of Washington in 2005. Dr. Hedderson's current research interests focus on perinatal epidemiology, with an emphasis on the roles of behaviors, genetics and biomarkers in the pathogenesis of gestational diabetes. She is interested in genetic epidemiology, particularly in applying genetic epidemiological methods to research of metabolic disorders related to perinatal and reproductive outcomes. Dr. Hedderson also has a long-standing research interest in lifestyle intervention studies to improve reproductive outcomes and maternal and child health.

Current Position(s):

Research Scientist I, Division of Research, Kaiser Permanente Northern California

Pharmacogenomics of Membrane Transporters

As part of Pharmacogenomics of Membrane Transporters Research Network we will collaborate with UCSF on a multi-site study of the genetic determinants of response to Metformin in African Americans. The aim of the study is to collect biospecimens and phenotypic measurements from a cohort of African American diabetic patients on Metformin monotherapy. Aim 2 will be to undertake a two-stage genomewide association study to identify loci associated with glycemic response to metformin.
Funder: National Institute of General Medical Sciences
Principal Investigator: Hedderson, Monique

Gestational weight gain and risk of gestational diabetes in preterm delivery

We propose to conduct a cohort study among the estimated 11,000 multi-ethnic KPNC health plan members who completed a detailed survey as part of the RPGEH in 2007 and had a subsequent live birth delivered up to 2011. The study aims are 1) To evaluate whether increasing rate of gestational weight gain up to the time of screening for GDM is associated with an increased risk of GDM 2) To examine total rate of gestational weight gain and the risk of preterm birth sub-types: spontaneous preterm birth and medically indicated preterm birth.
Funder: Health Resources and Services Administration
Principal Investigator: Hedderson, Monique

Trends in Primary Cesarean Deliveries in Kaiser Permamente Northern California

Our primary aim is to examine temporal trends in primary cesarean deliveries among singleton births from 1995 to 2007 in Kaiser Permanente Northern California using information from the Kaiser Permanente Pregnancy Glucose Tolerance Registry. We will explore whether the trends in cesarean deliveries vary by maternal BMI, glucose tolerance level and race/ethnicity.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Hedderson, Monique

Pregravid biomarkers and risk of GDM

To examine pregravid biomarkers of metabolic risk (Adiponectin, HMW adiponectin, CRP, GGT, Fetuin-A and LDL particle size) in relation to risk of GDM, among women who participated in the MHC (1985-1996) and had a subsequent pregnancy in KPNC.
Funder: Nat. Inst. of Child Health and Human Dev.
Principal Investigator: Hedderson, Monique

Pilot Study to Assess Metformin Monotherapy Users and Genetic Variation in Response to Metformin

This pilot study in joint collaboration with the UCSF Pharmacogenetic Research Network, using Kaiser Permanente Northern California (KPNC) electronic data, will generate descriptive data to determine the number and demographics of patients identified in the KPNC diabetes registry who initiated metformin monotherapy during 2007.
Funder: National Institute of General Medical Sciences
Principal Investigator: Hedderson, Monique

Kaiser Permanente Division of Research