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Learnings in Diabetes Prevention from an Integrated Delivery System

Includes evaluation studies of a health plan employer partnership that identifies employees at high risk for diabetes on intervenes using outreach and communication, feedback, incentives, and health coaching to change behaviors and reduce risk; a broader evaluation of a new telephone health coaching program that will ultimately be available to all adult members; and the Regional Perinatal Service Centers region-wide program for reducing risk among women who have had gestational diabetes mellitus.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Selby, Joe

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Multi-institutional Consortium for CER in Diabetes Treatment and Prevention

To build a standardized diabetes registry (including children and adults) across participating HMORN sites, to be used for comparative effectiveness studies of diabetes prevention and CVD risk reduction.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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UCSF/Kaiser-DOR Program for Developing Independent Women's Health Researchers

Funder: Nat. Inst. of Child Health and Human Dev.
Principal Investigator: Selby, Joe

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The Impact of Intensive Versus Usual Glucose Control and Multiple Risk Factor Intervention Approaches in Individuals With Type 2 Diabetes

This study will address the question of whether intensive glycemic control in adult patients with type 2 diabetes leads to improved short- and longer-term outcomes compared with less intensive therapy, and to determine whether its benefit varies as a function of age, prior cardiovascular disease, blood pressure, or LDL-cholesterol control.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Effectiveness of Immediate Vs. Delayed Use of Metaformin in New-Onset T2 Diabetes

Effectiveness of Immediate Vs. Delayed Use of Metaformin in New-Onset T2 Diabetes 
Funder: Kaiser Foundation Research Institute
Principal Investigator: Selby, Joe

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Stakeholder Support for the Diabetes Multicenter Research Consortium

This study aims to prioritize comparative effectiveness research needs in the area of diabetes and to conduct original research to address high priority comparative effectiveness questions.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Analytic Briefs for Supporting Comparative Effectiveness Research and Systematic Reviews in Diabetes

The overall aim of this study is to evaluate the feasibility of creating nationally representative, diabetes-specific reports and describe their utility to various stakeholders.  
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Diabetes Multicenter Research Consortium

This HMO Research Network project is a task order-driven contract arrangement with the Agency for Healthcare Research and Quality to conduct studies of comparative effectiveness in the treatment of type 2 diabetes. The first funded task order involves a comparison of bariatric surgery with usual medical care in persons with diabetes. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Meaningful Variation in Performance (MVP)

The MVP project synthesizes the existing literature on the topic of performance management in health care and conducts supportive empirical analyses exploring appropriate levels of measurement using Kaiser Permanente Northern California electronic databases.
Funder: Council of Accountable Physician Practices
Principal Investigator: Selby, Joe

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Comparative Effectiveness and Safety of Second-Line Anti-Hypertensive Agents

This project examines issues related to collection of standardized data suitable for research from electronic medical records of multiple health care systems that are members of the HMO Research Network. One of the pilot projects is a longitudinal study among patients with hypertension, measuring current treatment practices and the comparative effectiveness of various pharmacotherapies. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Feedback of Treatment Intensification Data to Reduce Cardiovascular Disease Risk

This study assesses whether the use of systematic feedback on need for treatment intensification in patients with poor control of CVD risk factors improves risk factor control. Using a cluster-randomized trial design, this project leverages health information technology, including Kaiser Permanente’s electronic health record. 
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Selby, Joe

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Investigation of an Unexplained Dermopathy, California

This study of an unexplained dermopathy, sometimes known as Morgellon's syndrome, involves a Web-based questionnaire and a follow-up clinical examination of eligible Kaiser Permanente members that includes dermatologic, neuropsychiatric and general medical examinations, laboratory work and a skin biopsy. 
Funder: Centers for Disease Control and Prevention
Principal Investigator: Selby, Joe

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Improving Adherence and Intensification of Medications Among Diabetes Patients

This multi-site, cluster-randomized control trial implements and evaluates a tailored clinical pharmacist-based intervention to improve cardiovascular disease risk factor control among diabetes patients by addressing both poor medication adherence and inadequate medication intensification for blood pressure, glycemia and lipid medications.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Selby, Joe

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Building Interdisciplinary Research Careers in Women's Health

The overall goal of the UCSF-Kaiser BIRCWH Program is to increase the number and quality of researchers from diverse disciplines who become outstanding independent investigators skilled at leading multidisciplinary teams in translational and clinical research focused on areas of women’s health. 
Funder: Nat. Inst. of Arthritis & Musc-skel & Skin Disease
Principal Investigator: Selby, Joe

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Translating Research into Action for Diabetes (TRIAD II)

The goals of this study are to describe current levels of diabetes care, analyze system-level determinants of level of care, study health care professional and patient-level factors that influence the effectiveness of care, develop new quality indicators, and identify and evaluate interventions that aim to improve levels of screening and risk management for patients with diabetes. 
Funder: Centers for Disease Control and Prevention
Principal Investigator: Selby, Joe