Clinical Prediction of Hepatotoxicity & Comparative Hepatic Safety of Medications
Evaluation of Hy's Rule for hepatotoxicity
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Corley, Douglas
Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal Cancer (SCHOLAR)
A case-control study to evaluate the associations between commonly performed tests (e.g. colonoscopy) and mortality from colon cancer.
Funder: National Cancer Institute
Principal Investigator: Corley, Douglas
Cancer Center Clinical Investigator Research Program (CIRP)
Perform a nested case-control study to evaluate the association between screening with serum alpha-fetoprotein and/or ultrasound and mortality from hepatocellular carcinoma.
Funder: Mount Zion Health Fund
Principal Investigator: Corley, Douglas
Adipokines and Barrett's Esophagus
Evaluate role of adipokines in the development of Barrett's esophagus and esophageal adenocarcinoma, using the NCI Barrett's Esophagus and Esophageal Adenocarcinoma Consortium.
Funder: National Institutes of Health
Principal Investigator: Corley, Douglas
Gender, Obesity, C-Reactive Protein and Oxidative Stress
Epidemiological data and a trial in smokers suggest that Vitamin C supplementation may decrease C-reactive protein, a marker of inflammation associated with heart disease. The current study is a randomized trial of vitamin C versus placebo among obese patients with elevated levels of C-reactive protein.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Corley, Douglas
Long-Term Morbidity and Mortality for Liver Transplant Recipients: Understanding the Causes of Death and Identifying Modifiable Risk Factors to Improve Survival (formerly "Outcomes of Liver Transplantation")
The goal is to determine the long-term outcomes of liver transplant patients, their causes of death, and potential morbidities (renal failure, diabetes, etc.).
Funder: Univ. of California, San Francisco Project Grant
Principal Investigator: Corley, Douglas
Routine Blood Count and Urine Analysis in Relation to Subsequent Cancer Risk
This study evaluates the association between abnormal values on routine laboratory tests, such as hematocrit or iron counts, on the subsequent risk of cancer diagnosis, in particular esophageal and renal cell carcinoma.
Funder: National Cancer Institute
Principal Investigator: Corley, Douglas
Barrett's Esophagus: Risk Factors in Women
This study utilizes pooling of several existing case-control studies of Barrett's esophagus (a condition that is a preneoplastic risk factor for esophageal adenocarcinoma) to evaluate several risk factors for Barrett's esophagus among women and contrast them with men.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Corley, Douglas
Randomized, Double-Blinded Phase II Trial of Esomeprazole Versus Esomeprazole + Two Doses of Aspirin in Barrett's Esophagus Patients
This is a randomized trial of aspirin vs. placebo for molecular markers of neoplastic progress in Barrett's esophagus.
Funder: National Cancer Institute
Principal Investigator: Corley, Douglas
Obesity and Cancers of the Esophagus and Stomach
This study evaluates the associations between obesity, body fat distribution, gastroesophageal reflux symptoms, and esophageal adenocarcinoma using the MHC (spell out?) data set.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Corley, Douglas
Case-control Study of Surveillance for Barrett's Esophagus
This case-control study of persons with Barrett's esophagus evaluates associations between surveillance and survival from esophageal adenocarcinoma.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Corley, Douglas
Proton Pump Inhibitors, Iron Deficiency, and B12 Deficiency
The goal of this study is to evaluate whether long-term proton pump inhibitor use is associated with an increased risk of gastrointestinal malignancies, iron deficiency, or vitamin B12 deficiency.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Corley, Douglas
Long-term, Prospective, Observational Study of the Risk of Cancer Among Pantoprazole (Protonix®) Users
This study aims to learn if there is an increased risk of cancer with pantoprazole (Protonix®), relative to the other proton pump inhibitors.
Funder: Wyeth-Lederle
Principal Investigator: Corley, Douglas
Epidemiology and Incidence of Barrett's Esophagus
This case control study evaluates several environmental and personal risk factors for Barrett's esophagus, such as diet, obesity, alcohol intake, iron stores, and molecular markers associated with obesity.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Corley, Douglas
Epidemiology and Incidence of Barrett's Esophagus
This study extends current knowledge regarding the epidemiology of Barrett's esophagus, increases understanding about why Barrett's esophagus/esophageal adenocarcinoma occurs predominantly in Caucasian males, estimates the population-based incidence of Barrett's esophagus diagnosis in the United States, and provides information for future intervention trials.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Corley, Douglas
A Natural History Study of Patients with Advanced Illness
An evaluation of adverse gastrointestinal and cardiovascular effects from chronic pain medication use.
Funder: Wyeth-Lederle
Principal Investigator: Corley, Douglas
Impact of endoscopist on diagnostic yield of colonoscopy
This study evaluates the variation in polyp yield between different physicians performing colonoscopy.
Funder: Kaiser Permanente Community Benefit Research
Principal Investigator: Corley, Douglas