Perception of Neighborhood Safety and Children's Physical Activity
This study aims to determine if parental perception of neighborhood safety versus danger impacts physical activity for 11- to 12-year-old children.
Funder: Robert Wood Johnson Foundation
Principal Investigator: Aalborg, Annette
Outcomes of Bariatric Surgery among Patients with Bipolar Disorder
This retrospective cohort study will examine bariatric surgery outcomes among 5155 patients (1.6% with bipolar disorder, 30% with major depressive disorder, 68% with no affective disorder) who underwent bariatric surgery between 2006 and 2009 in Kaiser Permanente Northern California.
Funder: National Institute of Mental Health
Principal Investigator: Ahmed, Ameena
Improving Contraceptive Use in High-Risk Women
This project lays the ground work for conducting a large-scale theory driven, multi-component clinic-based intervention to improve contraceptive use and reduce unintended pregnancy rates among young, low-income, and minority women receiving care at family planning clinics and engage fellows and junior faculty in the development of patient oriented research to improve contraceptive use behavior among women at high-risk for unintended pregnancy.
Funder: Nat. Inst. of Child Health and Human Dev.
Principal Investigator: Raine-Bennett,Tina
Retrospective Assessment of Military Occupations & Neurodegenerative Disease
The specific aims of this project are: (1) to develop exposure assessment methodology for collecting objective information about military occupations and exposures, and (2) to apply the newly developed methodology to determine whether military service is associated with ALS and PD in three completed population-based case-control studies conducted in Northern California and Western Washington State.
Funder: Nat. Inst. for Occupational Safety and Health
Principal Investigator: Van Den Eeden, Stephen
Effective Care of Latinos with Diabetes and Limited English Proficiency
This study focuses on respondents from DISTANCE to determine if there is a differential impact of language concordant care on the outcomes of Latino patients with diabetes and limited English proficiency.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Karter, Andrew
Lactation and Incidence of Type 2 Diabetes in CARDIA Women
The goals of our study are to prospectively examine whether longer duration of lactation is associated with development of type 2 DM in women of reproductive age during the 25-year CARDIA study period (1986-2011) and assess changes in risk factors.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Gunderson, Erica
Obesity in Ovarian Cancer Prognosis
The research project aims to examine the association of weight and weight change on ovarian cancer survival and CA-125 levels, a tumor marker used routinely in the clinical management of ovarian cancer.
Funder: National Cancer Institute
Principal Investigator: Kushi, Lawrence
Pregravid Blood Pressure & Adverse Pregnancy Outcomes: SGA and Preterm Birth
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Gunderson, Erica
Outcomes among patients with recurrent Clostridium difficile infection (CDOC project - C Diff OutComes)
This project will examine predictors of and outcomes after recurrent Clostridium difficile infection in adults.
Funder: Merck and Co., Inc.
Principal Investigator: Escobar, Gabriel
Clinical Prediction of Hepatotoxicity & Comparative Hepatic Safety of Medications
Evaluation of Hy's Rule for hepatotoxicity
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Corley, Douglas
The Population-Based Effectiveness in Asthma and Lung Diseases (PEAL) Network
This project will create a new infrastructure to accelerate comparative effectiveness research in asthma and other lung diseases. We will form the Population-Based Effectiveness in Asthma and Lung Diseases (PEAL) Network by aligning and linking computerized data from five health care systems with diverse structural and demographic characteristics.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Fung, Vicki
The Overlap Syndrome of COPD and OSA: Determinants of Health Status and Outcomes
The FLOW Study also seeks to examine factors contributing to the development of disability among COPD patients. The FLOW Study is currently measuring respiratory impairment factors while subjects are awake, utilizing such measures as spirometry and oxygen saturation.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Validation of Keratinocyte Carcinoma Registry at Kaiser Permanente
The goal is to develop a population-based registry of KPNC members diagnosed with keratinocyte carcinoma as identified by Systemized Nomenclature of Medicine (SNOMED) codes assigned electronically at time of pathology diagnosis.
Funder: National Cancer Institute
Principal Investigator: Asgari, Maryam
MsFLASH02 – Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation
The goal of this project is to test the efficacy of aerobic exercise, yoga and omega 3 fatty acids on the frequency and bother of vasomotor symptoms in a 3 by 2 factorial randomized trial.
Funder: National Institute of Aging
Principal Investigator: Sternfeld, Barbara
Alameda County Network Program to Reduce Cancer Disparities
The goal of this project is to develop a Regional Center for Reducing Cancer Disparities through Outreach, Research and Training based in Alameda County, California, focusing on religion using Faith Based interventions that may be conducted in Faith Placed organizations.
Funder: National Cancer Institute
Principal Investigator: Somkin, Carol
Pharmacogenomics of Membrane Transporters
As part of Pharmacogenomics of Membrane Transporters Research Network we will collaborate with UCSF on a multi-site study of the genetic determinants of response to Metformin in African Americans. The aim of the study is to collect biospecimens and phenotypic measurements from a cohort of African American diabetic patients on Metformin monotherapy. Aim 2 will be to undertake a two-stage genomewide association study to identify loci associated with glycemic response to metformin.
Funder: National Institute of General Medical Sciences
Principal Investigator: Hedderson, Monique
Gestational weight gain and risk of gestational diabetes in preterm delivery
We propose to conduct a cohort study among the estimated 11,000 multi-ethnic KPNC health plan members who completed a detailed survey as part of the RPGEH in 2007 and had a subsequent live birth delivered up to 2011. The study aims are 1) To evaluate whether increasing rate of gestational weight gain up to the time of screening for GDM is associated with an increased risk of GDM 2) To examine total rate of gestational weight gain and the risk of preterm birth sub-types: spontaneous preterm birth and medically indicated preterm birth.
Funder: Health Resources and Services Administration
Principal Investigator: Hedderson, Monique
Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal Cancer (SCHOLAR)
A case-control study to evaluate the associations between commonly performed tests (e.g. colonoscopy) and mortality from colon cancer.
Funder: National Cancer Institute
Principal Investigator: Corley, Douglas
Epidemiology: Oxidative Stress and Early Atherosclerosis
The renewal of this study utilizes and expands the infrastructure of the CARDIA year 25 examination planned for 2010-2011 to obtain additional blood and urine samples and to perform additional biochemical analyses to elucidate early stages in the pathogenesis of CVD and etiologically related conditions.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Sidney, Stephen
Trends in Primary Cesarean Deliveries in Kaiser Permamente Northern California
Our primary aim is to examine temporal trends in primary cesarean deliveries among singleton births from 1995 to 2007 in Kaiser Permanente Northern California using information from the Kaiser Permanente Pregnancy Glucose Tolerance Registry. We will explore whether the trends in cesarean deliveries vary by maternal BMI, glucose tolerance level and race/ethnicity.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Hedderson, Monique
A New Translational Tool for Studying the Role of Breathing in Meditation
The present study investigates the effects of an eight-week mindful breathing intervention on 24-hr blood pressure, breathing rate, and an index of pCO2, the amount of CO2 in expired air (PetCO2).
Funder: Nat. Ctr. for Complementary and Alt. Medicine
Principal Investigator: Avins, Andrew
The Identification of Risk Factors for the Complex MS Phenotype
The principal goals of this study are to identify genetic and nongenetic risk factors for occurrence of MS and MS progression through whole genome scans of our previously collected and assessed MS case-control study population.
Funder: Nat. Inst. of Allergy and Infectious Diseases
Principal Investigator: Schaefer, Catherine
Use of secure electronic messaging with providers in KPNC
We will examine patient use of secure electronic messaging services (e.g., "Email my doctor"), and survey responses about experience with and perceptions of secure electronic messaging.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Reed, Mary
HIV Infection, Immunodeficiency and Skin Cancer
The goald is to: 1. To compare the tumor subtype (basal cell carcinoma, squamous cell carcinoma, and melanoma) and location (sun exposed vs. non-sunexposed) between HIV-infected persons and HIV-uninfected persons with skin cancer. 2. To compare the risk of skin cancer between those with and without HIV infection. 3. To determine the association of immunodeficiency and skin cancer risk. 4. To compare the tumor invasiveness of cancers according to HIV infection status and level of immunodeficiency.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Asgari, Maryam
Learnings in Diabetes Prevention from an Integrated Delivery System
Includes evaluation studies of a health plan employer partnership that identifies employees at high risk for diabetes on intervenes using outreach and communication, feedback, incentives, and health coaching to change behaviors and reduce risk; a broader evaluation of a new telephone health coaching program that will ultimately be available to all adult members; and the Regional Perinatal Service Centers region-wide program for reducing risk among women who have had gestational diabetes mellitus.
Funder: Centers for Disease Control and Prevention
Principal Investigator: Selby, Joe