The Overlap Syndrome of COPD and OSA: Determinants of Health Status and Outcomes
The FLOW Study also seeks to examine factors contributing to the development of disability among COPD patients. The FLOW Study is currently measuring respiratory impairment factors while subjects are awake, utilizing such measures as spirometry and oxygen saturation.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Protein and Lipid Biomarkers for Prospective Prediction of Type 2 Diabetes: a CARDIA Ancillary Study
The overall goal of this proposal is to investigate the ability of a panel of protein and lipid biomarkers to predict the future incidence of diabetes in a population based study which includes both Caucasians and African Americans.
Funder: Tethys Bioscience
Principal Investigator: Iribarren, Carlos
SPIROMICS: Clinical Centers
The goals of this study are to: 1) identify subpopulations of subjects with COPD who are likely to be similar with respect to molecular mechanism of disease, and 2) identify and validate indices of disease severity and progression, which may be useful as intermediate outcome measures in clinical trials.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Descriptive Epidemiology of Short QT Interval
This study seeks to better understand the incidence, prevalence, comorbidities, and natural history of short QT in a representative population to help guide clinical decision making, fill gaps in knowledge in the general medical community, and mitigate potential risk.
Funder: Johnson and Johnson
Principal Investigator: Iribarren, Carlos
Physical and Social Environmental Factors in Adult Asthma
This study analyzes the cumulative risk of combined physical environmental and social environmental factors that affect asthma outcomes, giving particular emphasis to relationships that might be amenable to intervention/secondary-tertiary prevention strategies designed to improve outcomes.
Funder: Nat. Inst. of Environmental Health Sciences
Principal Investigator: Iribarren, Carlos
The Impact of Secondhand Smoke Exposure on COPD Outcomes
This study evaluates the role of education in the incidence of diabetic complications in a large, well-characterized population within an integrated, managed care setting (Kaiser Permanente).
Funder: Tobacco-Related Disease Research Program
Principal Investigator: Iribarren, Carlos
UCSF Center of Excellence on Secondhand Smoke (aka FLOW-FAMRI)
This study seeks to elucidate the factors that determine the risk of developing disability and poor health outcomes among adults with COPD, controlling for degree of pulmonary function impairment; evaluate the impact of specific functional limitations on the risk of developing disability in daily activities and work among relatively young adults with COPD; and elucidate the impact of disability on future adverse health outcomes.
Funder: Flight Attendants' Medical Research Institute
Principal Investigator: Iribarren, Carlos
Asthma and the Risk of Anaphylaxis
This study aims to define the incidence of anaphylaxis among adults and adolescents with asthma; define whether anaphylaxis is more common in asthma than in a matched control population; and elucidate risk factors for anaphylaxis among adults and adolescents with asthma.
Funder: Genentech
Principal Investigator: Iribarren, Carlos
Function, Living, Outcomes and Work in COPD (FLOW)
This study seeks to elucidate the factors that determine the risk of developing disability and poor health outcomes among adults with COPD, controlling for degree of pulmonary function impairment; to evaluate the impact of specific functional limitations on the risk of developing disability in daily activities and work among relatively young adults with COPD;and also to elucidate the impact of disability on future adverse health outcomes.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Whole Genome Association for Early Coronary Artery Disease and Related Phenotypes (ADVANCE)
This project aims to examine the genetic predisposition to early-onset coronary artery disease by performing a whole genome association study of about 500 cases and 500 coronary disease-free controls (Stage 1).
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Serum Proteomic Profiles for Prospective Prediction of Acute Myocardial Infarction
The study seeks to determine the prognostic value of proteomic profiles in 500 acute myocardial infarction (AMI) cases (including ST elevation and non-ST elevation MI), and 1,000 age, sex, race, serum date, matched controls free of any history of atherosclerotic cardiovascular disease with available serum samples in the Kaiser Permanente Northern California-Orentreich Foundation Serum Repository samples.
Funder: Aviir Inc.
Principal Investigator: Iribarren, Carlos
Inflammation Genomics and Atherosclerosis Project (IGAP)
This study examines the associations of common variation in inflammation/thrombosis genes with intermediate quantitative phenotypes and subclinical coronary atherosclerosis in the Coronary Artery Risk Factor Development in Young Adult (CARDIA) Study, a large, biracial cohort study.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Iribarren, Carlos
Outcomes of Pulmonary Incidental Findings on Cardiac Computed Tomography in Older Adults
This study aims to describe the prevalence and characteristics (location, size, appearance) of asymptomatic lung nodules incidentally detected on cardiac CT; and assess its natural history (progression, no change and/or regression on follow-up examinations within the health plan) and their prognosis (rate of lung cancer development) up to three and a half years later.
Funder: Kaiser Permanente Community Benefit Program
Principal Investigator: Iribarren, Carlos