Effectiveness of medical therapy, endovascular therapy, and surgery for peripheral arterial disease
The objective is to inform current practice regarding peripheral arterial disease (PAD) treatment as follows: 1) to assemble a registry of PAD patients (n=60,000) in 2 integrated healthcare delivery systems and collect detailed chart abstracted procedural data (n=3,000) for those who undergo endovascular or surgical revascularization; 2) to describe demographics, co-morbidities, medications, and risk factor control of diagnosed PAD patients by medical therapy only, endovascular therapy or surgery; and 3) to assess the comparative effectiveness of surgery versus endovascular therapy for PAD.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Go, Alan
Mental Health Disorders & Medication Adherence & Outcomes in Hypertension, Atrial Fibrillation & Venous Thromboembolism within the CVRN
To examine the relationship between three prevalent mental health disorders (depression, anxiety disorders, and ADHD), their associated therapies, and outcomes for hypertension, atrial fibrillation and venous thromboembolic disease within the NHLBI-sponsored Cardiovascular Research Network (CVRN). These outcomes will include intermediate markers such as medication adherence and surrogate outcomes (e.g., systolic blood pressure and percentage of time spent at a therapeutic INR), as well as long-term clinical outcomes such as thromboembolic events (e.g., acute myocardial infarction, ischemic stroke, recurrent venous thromboembolism) and major bleeding.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Go, Alan
Protocol development with stakeholders to compare the effectiveness of antiplatelet and anticoagulation therapy in patients undergoing coronary interventions
To develop protocol with stakeholders to compare the effectiveness of antiplatelet and anticoagulation therapy in patients undergoing coronary interventions.
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Go, Alan
Retinopathy in Chronic Renal Insufficiency
This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study proposes to do follow-up digital retinal photographs to assess the incidence and progression of retinal abnormalities and their association with cardiovascular disease and progression of chronic kidney disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Improved Estimates of the Comparative Treatment Effects of CABG and PCI
This ARRA-funded study will expand ongoing work through the joint Kaiser-Stanford American Heart Association Cardiovascular Outcomes Research Center to compare the effectiveness and safety of coronary artery bypass surgery versus percutaneous coronary intervention for the treatment of coronary heart disease using different statistical and analytic strategies to reduce the impact of treatment selection bias and confounding.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Go, Alan
Prospective Evaluation of Acute Kidney Injury (PEAK) Cohort
Prospective Evaluation of Acute Kidney Injury (PEAK) Cohort
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Chronic Renal Insufficiency Cohort Study II
Chronic Renal Insufficiency Cohort Study II
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Management and Outcomes of Heart Failure with Preserved Systolic Function
Management and Outcomes of Heart Failure with Preserved Systolic Function
Funder: Kaiser Foundation Research Institute
Principal Investigator: Go, Alan
Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Network
Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Network
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Go, Alan
Centers for Education and Research on Therapeutics (CERTs)
Centers for Education and Research on Therapeutics (CERTs)
Funder: Agency for Healthcare Research and Quality
Principal Investigator: Go, Alan
Oral Bisphosphonate Therapy and Risk of Atrial Fibrillation in Women
Oral Bisphosphonate Therapy and Risk of Atrial Fibrillation in Women
Funder: Food and Drug Administration
Principal Investigator: Go, Alan
Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI)
Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI)
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
American Heart Association Outcomes Research Center
American Heart Association Outcomes Research Center
Funder: American Heart Association
Principal Investigator: Go, Alan
Chronic Renal Insufficiency Cohort 2 (CRIC 2)
This project establishes a cohort of participants from the CRIC 1 study with chronic kidney disease to have long term prospective follow-up on progression of kidney disease and a variety of different outcomes.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
HMO Research Network CV Research Network (CVRN)
This project establishes a 15-member Cardiovascular Disease Research Network (CVRN) sponsored by the National Heart, Lung and Blood Institute. It includes four to five core projects that examine the epidemiology, management and outcomes of cardiovascular risk factors and conditions.
Funder: National Heart, Lung, and Blood Institute
Principal Investigator: Go, Alan
Serum Proteomic Profiles for Prediction of Coronary Heart Disease Events: The ADVANCE Study
This study examines prospectively the prognostic ability of serum proteomic profiles for cardiovascular events and death among selected patients from the ADVANCE Study, after adjustment for traditional vascular risk factors and other potential confounders.
Funder: Aviir Inc.
Principal Investigator: Go, Alan
Hispanic Chronic Renal Insufficiency Cohort
This study is recruiting additional Hispanic participants with chronic kidney disease into the Chronic Renal Insufficiency Cohort (CRIC) Study to examine whether the rates of loss of kidney function and subclinical and clinical cardiovascular disease varies among Hispanics versus other race/ethnic groups, after accounting for traditional risk factors.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Risks of Warfarin for Elders with Atrial Fibrillation
This study examines the adverse bleeding outcomes associated with anticoagulation therapy in older patients with chronic nonvalvular atrial fibrillation.
Funder: National Institute of Aging
Principal Investigator: Go, Alan
CRIC Plus: Study of Advanced Chronic Renal Insufficiency
This study aims to examine how clinical characteristics and morbidity in patients with advanced chronic kidney disease influence the risk of adverse clinical outcomes after the onset of end-stage renal disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Differential RNA Expression Profiling by Severity of Chronic Heart Failure
The study prospectively enrolls 160 adults with varying severity of chronic heart failure, as well as 40 control subjects without heart failure, to examine the utility of RNA expression profiling for assessing the presence and severity of heart failure compared with other biomarkers such as B-type naturetic peptide.
Funder: ChondroGene
Principal Investigator: Go, Alan
Genetics of Atherosclerosis in Renal Disease
This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) study obtains additional electron-beam tomography exams for the measurement of coronary artery calcification at four different clinical centers in the CRIC study.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
MAVERICK
This study leverages previous work to establish a larger, more contemporary, and well-characterized cohort of persons with chronic kidney disease (CKD) to examine the relevant issues in the epidemiology, management, and outcomes in this growing population.
Funder: Amgen
Principal Investigator: Go, Alan
Cognitive Decline in Chronic Renal Insufficiency
This ancillary study to the prospective Chronic Renal Insufficiency Cohort (CRIC) Study examines the association between severity of kidney dysfunction and risk of cognitive decline, whether it varies by demographic characteristics and diabetes status, and potential mediating pathways including dietary protein intake and subclinical and clinical cardiovascular disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Pulse Wave Velocity in Chronic Kidney Disease
This study seeks to describe the spectrum of pulse wave velocity (PWV) values, a measure of aortic stiffness, in a large cohort of adults with mild-to-moderate chronic kidney disease.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Linking Acute, Chronic and End-Stage Renal Disease
This study examines the natural history of chronic kidney disease, its association with the risk of acute renal failure, and the impact of acute renal failure on the future short and long-term risk of end-stage renal disease among ~2,000,000 adult members within Kaiser Permanente Northern California with known renal function between 1996-2005.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Heart Failure Incidence and Progression in Renal Disease
This ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study describes the epidemiology of chronic heart failure prevalence and incidence among 3,000 adults with mild-to-moderate chronic kidney disease and examines how the severity of kidney dysfunction affects the prognosis and disease-specific quality of life in patients with kidney disease and chronic heart failure.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
Epidemiology and Outcomes of Anemia Complication Chronic Heart Failure Within a Large HMO
This study examines how the association between the level of kidney function and level of blood hemoglobin increases the risks of death, being hospitalized for heart failure, and excess medical costs in a large, diverse sample of adults with chronic heart failure.
Funder: Amgen
Principal Investigator: Go, Alan
Study of the Care and Outcomes of Chronic Renal Insufficiency Cohort (CRIC)
This project establishes a joint San Francisco Bay Area Clinical Center between Kaiser Permanente Northern California and the University of California San Francisco to contribute to the NIDDK-sponsored cohort of 3,000 patients with mild-to-moderate chronic renal insufficiency.
Funder: Nat. Inst.of Diabetes & Digestive & Kidney Disease
Principal Investigator: Go, Alan
ROCKET Study: A Prospective Randomized Double-blind Double-dummy
This Phase III, double-blinded, double-dummy randomized controlled trial compares the efficacy and safety of the oral factor Xa inhibitor, rivaroxaban, against adjusted-dose warfarin therapy for stroke prevention in adults with chronic nonvalvular atrial fibrillation.
Funder: Johnson and Johnson
Principal Investigator: Go, Alan
STABILITY Study: A Clinical Outcomes Study of Darapladib versus Placebo in Subjects with Chronic Coronary Heart Disease to Compare the Incidence of Major Adverse Cardiovascular Events (MACE). (STABILITY)
This is a multicenter, phase 3 placebo-controlled trial of the efficacy of an oral inhibitor of LpPLA2 on cardiovascular and other outcomes in adults with stable coronary heart disease and additional vascular risk factors.
Funder: GlaxoSmithKline
Principal Investigator: Go, Alan